Resources

Proteomics Databases



Metabolomics Databases

• • Detection of Protein Deamidation Using High-Resolution Mass Spectrometry

  Proteins are the central molecules of life, with their structure and function heavily influenced by specific post-translational modifications (PTMs). Deamidation is one of the most common PTMs, typically occurring at asparagine (Asn) and glutamine (Gln) residues. The occurrence of deamidation can lead to alterations in protein structure and function, affecting protein stability, activity, and interactions with other molecules.

• • Detection of Protein Complexes via 2D Blue Native/SDS-PAGE

  Protein complexes perform various functions within cells, and their dynamic nature and compositional diversity make them crucial subjects of study. Traditional protein separation techniques, such as SDS-PAGE, are effective at separating proteins but often fail to maintain the integrity of protein complexes.

• • Proteomics: Unveiling Scientific Principles

  Proteomics is one of the most important fields of study in biology, focusing on the comprehensive analysis of protein composition, structure, and function in organisms. It plays a crucial role in understanding cellular functions and biological processes.

• • Comparison of Protein Detection Methods by HPLC

  Protein is an important functional molecule in organisms, and it is of great significance for studying biological processes and developing biopharmaceuticals. Accurate identification methods are required for the study of protein structure and function. Among them, protein HPLC detection method is a commonly used technique.

• • Comparative Analysis of Protein Structure via Co-IP and Pull-Down

  Protein is an important functional molecule in living organisms, and its structure determines its function. Therefore, understanding the structure of proteins is crucial for understanding their function and the biological processes they participate in. In the field of biopharmaceutical research, scientists often use different methods to decipher the structure of proteins. Among them, Co-immunoprecipitation (CO-IP) and Pull Down are two commonly used methods.

• • Exploring Mass Spectrometry Software in Peptide Mass Studies

  Peptides are biopolymers composed of amino acids and possess wide-ranging biological activities and pharmacological applications. In the field of biopharmaceuticals, the research and development of peptide drugs have become a hot research direction. Mass spectrometry analysis of peptides is an indispensable part of peptide research.

• • Principle of Quantitative Tyrosine Phosphoproteomics Analysis

  Tyrosine phosphorylation is a pivotal molecular event in intracellular signaling, regulating critical cellular processes such as proliferation, differentiation, metabolism, and survival. Controlled by tyrosine kinases and phosphatases, tyrosine phosphorylation plays a central role in understanding signal transduction pathways.

• • Detection of Antibodies Using PCR Based Sequencing

  Antibodies are essential protein molecules in the immune system that specifically recognize and neutralize foreign pathogens. Traditional antibody detection methods, such as Enzyme-Linked Immunosorbent Assay (ELISA) and Immunofluorescence Assay (IFA), are widely used but have limitations in sensitivity, specificity, and result interpretation.

• • Steps of De Novo Protein Sequencing Based on Mass Spectrometry

  De Novo protein sequencing involves deducing the amino acid sequence of a protein directly from mass spectrometry data without any reference sequence. This process is intricate and meticulous. 

• • Detection of Protein Mutations Using High-Resolution MS

  Protein mutations play a significant role in biological research. Mutations can lead to changes in protein function, affecting physiological and pathological processes in organisms. Traditional methods for detecting protein mutations include Sanger sequencing and next-generation sequencing (NGS), which, despite their high accuracy and sensitivity, have limitations in complex protein samples.