Resources

Proteomics Databases



Metabolomics Databases

• • Single Nuclei Sequencing 10x

  Single nuclei sequencing 10x enables high-resolution genomic analysis at the level of individual cells. This technology allows researchers to obtain gene expression profiles from single cells, providing deep insights into complex biological systems. Its application spans a broad range of biomedical research fields, including cancer research, neuroscience, and immunology.   In cancer research, single nuclei sequencing 10x allows for the dissection of intratumoral heterogeneity by identifying gene expre......

• • 10x Single Cell DNA Sequencing

  10x single cell DNA sequencing enables high-resolution genomic analysis at the single-cell level. This technology allows researchers to identify and examine the genomic characteristics of individual cells within complex tissues or heterogeneous cell populations, overcoming the limitations of population-averaged data. Its core strength lies in enabling scientists to track genetic alterations in single cells, uncover variations among different cell types, and identify critical genetic markers associated......

• • 10x Genomics Whole Genome Sequencing

  10x Genomics whole genome sequencing is an advanced molecular biology technique designed to analyze the complete genome of an organism. It plays a vital role in molecular biology research by providing detailed information on genomic structure, function, and genetic variation. In basic research, 10x Genomics whole genome sequencing enables scientists to decipher genome architecture, explore gene functions, and identify interactions among genes. For example, by analyzing genomic variants and regulatory ......

• • 10x Genomics V(D)J Sequencing

  10x Genomics V(D)J sequencing is a single-cell sequencing technology primarily designed for detailed analysis of T cell and B cell receptors in the immune system. By capturing and sequencing V(D)J recombination sequences from individual cells, this technology enables researchers to explore immune cell diversity and specificity, thereby offering a powerful tool to gain deep insights into immune system mechanisms. It plays a crucial role in fields such as cancer immunotherapy, autoimmune disease researc......

• • Cancer Genomics and Proteomics

  Cancer genomics and proteomics are two foundational disciplines for exploring the molecular mechanisms of cancer. They respectively reveal the nature and evolution of tumors from the perspectives of genetic information and protein function. Cancer genomics focuses on alterations at the DNA level in cancer cells, including gene mutations, copy number variations, chromosomal rearrangements, and epigenetic modifications, all of which constitute the genetic basis of tumorigenesis. In contrast, cancer prot......

• • GTEx Proteomics

  GTEx (Genotype-Tissue Expression) Proteomics represents a systematic research initiative that extends the scope of the original GTEx project. It aims to construct a comprehensive landscape of protein expression across diverse human tissues and to further investigate how genetic variation influences the spatial distribution and functional modulation of proteins. While the initial GTEx project primarily focused on uncovering inter-individual variability and tissue specificity in gene expression using ........

• • Photoaffinity Labeling in Target and Binding Site Identification

  Photoaffinity labeling in target and binding site identification represents an advanced approach at the interface of chemistry and biotechnology. It is designed to accurately elucidate the interactions between small molecules and their protein targets, with a particular focus on the spatial localization and binding mechanisms of interaction sites. In contemporary drug discovery and molecular mechanism studies, understanding where and how small molecules engage with target proteins underpins the .........

• • TAILS Proteomics

  TAILS proteomics (Terminal Amine Isotopic Labeling of Substrates) is a high-resolution proteomic strategy designed to characterize the structural features of protein N-termini and to identify protease cleavage sites. This approach involves chemical labeling of protein N-terminal amines using isotopic reagents, followed by selective enrichment and mass spectrometry analysis, enabling sensitive and systematic detection of both native N-termini and neo-N-termini generated by proteolytic processing.

• • Detection Methods for Changes in Protein Glycosylation Levels

  Glycosylation is a crucial post-transcriptional modification process that influences the folding, stability, activity, and intercellular interactions of proteins. There are various methods to determine if the glycosylation modification level on a protein has changed, and each method has its characteristics and applicable scenarios. Here are some commonly used techniques: 1. Mass Spectrometry (MS) MS is a very powerful tool, especially when combined with liquid chromatography (LC-MS/MS)

• • Detection of Protein Phosphorylation Levels at Specific Sites

  Quantitative analysis of phosphorylation levels plays a crucial role in studying cell signaling, disease development, and drug mechanisms. The phosphorylation level at specific sites reflects the activity status of proteins and their involvement in biological processes.