Resources
Proteomics Databases
Metabolomics Databases
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• Western Blotting Quantitative
Western Blotting Quantitative is a widely used technique for detecting and quantifying the expression levels of specific proteins in complex biological samples. This method integrates electrophoretic separation, membrane transfer, and antibody-based detection to deliver precise quantitative insights into target protein expression. The standard workflow involves separating proteins via polyacrylamide gel electrophoresis, transferring them onto nitrocellulose or polyvinylidene fluoride (PVDF) membranes,......
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• Data-Independent Acquisition
Data-Independent Acquisition (DIA) is a valuable technique for quantitative proteomics analysis in complex biological samples. Unlike traditional Data Dependent Acquisition (DDA), which selectively fragments specific precursor ions and may overlook low-abundance proteins, Data-Independent Acquisition simultaneously captures all precursor ions and their fragments in a single experiment. This approach provides comprehensive and reproducible proteomic data, supporting biomedical research, drug developmen......
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• Advances in Antibody Characterization Techniques
Antibody characterization techniques encompass a comprehensive set of modern bioanalytical methods designed to systematically analyze and characterize the sequence, structure, modifications, affinity, and functional properties of antibody molecules. As essential components of the immune system, antibodies play an irreplaceable role in fundamental research, disease diagnostics, and the development of therapeutic antibody drugs. With the rapid advancement of biopharmaceutical technologies, innovative th......
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• Antibody Characterization Methods
Antibody Characterization Methods encompass a range of experimental and analytical techniques designed to determine the specificity, affinity, and functional properties of antibodies. These methods are essential not only for basic scientific research but also for disease diagnostics, therapeutic antibody development, and biomarker discovery. Antibodies exert their biological effects through specific interactions with target antigens; however, rigorously validating antibody specificity and functionalit......
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Antibody sequence analysis is a method used to comprehensively determine and characterize the amino acid sequences of antibody molecules through advanced biotechnological approaches. Antibodies, as protein molecules produced by the immune system, specifically recognize and bind to antigens, playing a critical role in immune defense mechanisms. In biomedical research, drug development, and disease diagnostics, antibodies are indispensable tools. However, the structural complexity and diversity of antib......
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• Antibody Characterization Techniques
Antibody characterization techniques encompass a comprehensive set of modern bioanalytical methods designed to systematically analyze and characterize the sequence, structure, modifications, affinity, and functional properties of antibody molecules. As essential components of the immune system, antibodies play an irreplaceable role in fundamental research, disease diagnostics, and the development of therapeutic antibody drugs. With the rapid advancement of biopharmaceutical technologies, innovative th......
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mRNA HPLC analysis is a precise analytical method for separating, identifying, and quantifying mRNA samples. By combining the separation efficiency of high-performance liquid chromatography (HPLC) with advanced detection techniques, this method provides detailed insights into the molecular structure and purity of mRNA. In response to the rapid growth of mRNA-based technologies, HPLC analysis has become an indispensable tool in quality control for mRNA drug development, vaccine research, and gene thera......
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• N-Terminal Protein Sequencing
N-terminal protein sequencing is a widely used method for determining the amino acid sequence at the N-terminus of a protein. By analyzing the initial amino acid residues of a protein chain, this technique reveals crucial information about protein structure and function, providing insights into biological roles, post-translational modifications, processing mechanisms, and domain architecture. It plays an essential role in proteomics, drug discovery, and biomedical research, particularly in protein str......
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• Co-Immunoprecipitation (Co-IP)
Co-immunoprecipitation (Co-IP) is a well-established technique extensively used in biochemical and molecular biology research to isolate and study target proteins and their interaction partners from complex biological mixtures. The method is based on the specific antigen-antibody interaction, enabling the selective enrichment and purification of target proteins. By leveraging the high specificity and affinity of antibodies, Co-IP effectively isolates target antigens from cell lysates, tissue homogenat......
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De novo antibody sequencing is an advanced analytical technique that leverages high-resolution mass spectrometry (HRMS) and bioinformatics tools to accurately determine the complete amino acid sequence of antibodies. Unlike conventional genomic sequencing or antibody gene library methods, this approach directly analyzes the protein sequence, enabling precise sequence determination without relying on genetic templates. This capability addresses the challenges of recognizing antibody variable regions (C......
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