Resources

Proteomics Databases



Metabolomics Databases

• • Single-Cell Metabolomics

  Single cell metabolomics refers to a scientific discipline that employs highly sensitive analytical techniques to investigate the metabolite composition and dynamic changes within individual cells. Unlike traditional metabolomics, which typically analyzes the average metabolic profile of a cell population, single cell metabolomics focuses on the metabolic state of individual cells. This approach enables a more precise understanding of cellular metabolic activity, reveals heterogeneity among cells, an......

• • PROTAC

  PROTAC (Proteolysis-targeting chimeras) is an innovative drug development strategy that uses the cell’s natural proteasomal degradation mechanism to selectively degrade target proteins, as opposed to traditional inhibition methods. This strategy overcomes the limitations of small molecule inhibitors, which are often restricted to targeting active sites and have difficulty addressing non-catalytic regions, thus offering a new approach for targeting "undruggable" proteins. The mechanism of PROTAC actio......

• • Accurate Mass Spectrometry

  Accurate mass spectrometry is a high-resolution and high-mass-accuracy technique used for precise molecular mass measurement and in-depth analysis of complex sample components. The core of accurate mass spectrometry is based on high resolution and mass accuracy, achieved with advanced mass analyzers like Fourier transform ion cyclotron resonance mass spectrometers (FT-ICR MS) and Orbitrap mass spectrometers. Mass resolution refers to the ability to distinguish ions with similar masses, while mass acc......

• • Bulk RNA Sequencing

  Bulk RNA sequencing is a technique that utilizes high-throughput sequencing technology to analyze the expression levels of all RNA molecules within a sample. Compared to traditional gene expression analysis methods, such as microarrays, bulk RNA sequencing offers superior sensitivity, resolution, and dynamic range. This approach allows for comprehensive capture of transcriptomic data, including both coding and non-coding RNA expression, gene fusions, alternative splicing events, and mutation analysis......

• • Cell Sequencing

  Cell sequencing is a technology that analyzes the genome, transcriptome, and epigenome of individual or groups of cells using high-throughput sequencing techniques. It allows for the investigation of gene expression, genetic variation, and epigenetic regulation at the single-cell or cell population level, providing detailed insights into cell heterogeneity, developmental trajectories, and functional states. This technology offers a novel perspective for biomedical research, with applications in cance......

• • LC-MS Chromatography

  LC-MS Chromatography is a modern analytical technique that combines liquid chromatography (LC) with mass spectrometry (MS). This approach leverages the unique advantages of both methods and has become an indispensable tool in life sciences, environmental analysis, drug research, and food safety. The liquid chromatography component primarily separates components in complex samples, while mass spectrometry provides high-resolution and high-sensitivity data by analyzing molecular mass and structure. The......

• • Single Nucleus RNA Sequencing

  Single nucleus RNA sequencing is a technique used to analyze RNA expression profiles within individual cell nuclei. It is particularly effective for samples where isolating intact cells is challenging, such as brain tissue rich in lipids. This technology allows researchers to obtain gene expression data at the single-cell level, which is critical for understanding complex biological processes, including development, disease progression, and cell differentiation. Compared to traditional RNA sequencing......

• • 10x Genomics Single-Cell Sequencing

  10x Genomics single-cell sequencing facilitates comprehensive genomic, transcriptomic, and epigenetic analyses at the individual cell level, unveiling cellular distinctions and functional insights. By integrating high-throughput sequencing with microfluidic technologies, this approach enables the exploration of gene expression, chromatin configurations, mutations, and genetic structures within single cells. Unlike traditional population-based sequencing methods, 10x Genomics single-cell sequencing exc......

• • 10x Sequencing

  10x sequencing represents an advanced method in genomics and transcriptomics research, leveraging microfluidic chip systems combined with spatial barcode labeling to achieve high-resolution sequencing at the single-cell level. Compared to traditional second-generation sequencing, 10x sequencing offers superior resolution, delivering detailed gene expression profiles, mutation data, and insights into genomic structural variations. These attributes make it particularly advantageous in single-cell and hi......

• • 10x Single-Cell RNA Seq

  10x Single-cell RNA sequencing (10x Single-cell RNA Seq)  employs high-throughput sequencing platforms to isolate, amplify, and sequence the RNA of individual cells, providing detailed insights into their transcriptional gene expression profiles. Unlike traditional bulk RNA sequencing, 10x single-cell RNA sequencing offers single-cell resolution to unveil cellular heterogeneity, which is crucial for understanding functions in complex biological systems, developmental processes, and disease mechanisms.......