Resources
Proteomics Databases
Metabolomics Databases
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• Protein Analysis Mass Spectrometry
Protein analysis mass spectrometry is a highly precise analytical technique used for the comprehensive study and identification of proteins. Proteins are essential biomolecules that carry out diverse functions in living organisms, including catalyzing biochemical reactions, providing structural support, transmitting cellular signals, and regulating gene expression. Protein analysis mass spectrometry enables scientists to investigate protein structure, function, and interactions with exceptional accura......
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SEC protein purification, short for size-exclusion chromatography, is a widely used technique for separating and purifying proteins, nucleic acids, and other biological macromolecules based on their molecular size differences. At its core, SEC protein purification relies on a column packed with a porous stationary phase. Molecules traverse the column at rates determined by their ability to diffuse into the pores of the matrix. Larger molecules, which cannot penetrate the pores, elute more rapidly, whi......
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Post-translational modification proteomics (PTMs proteomics) is a specialized research field dedicated to investigating chemical modifications occurring after protein synthesis and their functional roles within cellular systems. Protein functionality is determined not only by their amino acid sequences but also by the type, location, and dynamic regulation of post-translational modifications (PTMs). These chemical modifications, including phosphorylation, acetylation, methylation, ubiquitination, and ......
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Kinase profiling is a widely used methodology for investigating the activity of protein kinases and their regulatory roles in cellular signal transduction. Protein kinases are enzymes that catalyze the transfer of phosphate groups from ATP to specific substrate molecules, a process known as phosphorylation. This post-translational modification serves as a fundamental regulatory mechanism in various biological processes, including signal transduction, metabolic regulation, and cell cycle progression. C......
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Proximity proteomics is an advanced research strategy leveraging high-resolution mass spectrometry to investigate the spatial organization and functional dynamics of proteins within cellular environments. Unlike conventional proteomics, which primarily examines global protein expression and modifications, proximity proteomics focuses on the immediate molecular neighborhood and interaction networks of specific proteins with high spatial precision. By precisely labeling target proteins and their proxima......
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LC-MS protein analysis is a powerful bioanalytical technique widely used to characterize complex protein mixtures. By integrating liquid chromatography (LC) and mass spectrometry (MS), LC-MS combines protein separation with molecular weight and structural characterization. In LC, proteins are fractionated into distinct components based on their physical and chemical properties, while MS identifies and analyzes these components with high precision. This technique has become indispensable in biomedical ......
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• Target Validation in Drug Discovery
Target validation in drug discovery is a fundamental step in the drug development process. Its primary objective is to confirm whether specific molecules or proteins are involved in the onset and progression of diseases, and whether they can be targeted for effective drug intervention. During the early stages of drug discovery, target validation in drug discovery lays the foundation for the entire drug development pipeline, ensuring that the research direction is correct and has the potential for clin......
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Epitope mapping services systematically identify and analyze specific regions of antigens or pathogens to locate critical immune response sites, known as epitopes. These services rely on the specificity of antigen-antibody interactions, where the immune system detects epitopes-typically short peptide sequences on antigens-and initiates immune responses. Advances in high-resolution mass spectrometry technology have significantly enhanced the precision and accuracy of epitope mapping services, enabling ......
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• Fmoc Solid Phase Peptide Synthesis
Fmoc solid-phase peptide synthesis is a widely employed technique for the assembly of peptides. Unlike traditional liquid-phase synthesis, this method involves the stepwise attachment of amino acid monomers onto a solid-phase resin through a series of chemical reactions, ultimately constructing the desired peptide chain. The fundamental aspect of Fmoc solid-phase peptide synthesis lies in the application of the Fmoc group, a functional moiety that provides temporary protection to the amino group of am......
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Amino acid quantification involves accurately measuring the types and concentrations of amino acids in a sample using precise analytical techniques. Amino acids are the fundamental building blocks of proteins and are involved in numerous physiological processes, including cellular metabolism, signal transduction, and immune responses. The composition and relative abundance of amino acids in the body play a vital role in maintaining health and preventing diseases. This analysis has broad applications a......
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