Resources

Proteomics Databases



Metabolomics Databases

• • Glycoprotein TAP Detection

  In biomedical research, the detection and analysis of biomarkers are crucial. Among them, glycoproteins are an essential biomarker that plays a key role in many biological processes, including disease onset, progression, and treatment response. The Tandem Affinity Purification (TAP) of glycoprotein is an efficient detection method.   What is a Glycoprotein? Firstly, let's understand what a glycoprotein is. Glycoproteins are proteins that are rich in sugar molecules on their surface.

• • Dynamic Light Scattering Analysis of Protein Molecular Weight

  In biochemical research, gaining a profound understanding of the structure and function of proteins is of paramount importance. Among these, the measurement of protein molecular weight is a fundamental aspect. This paper will introduce a method for determining protein molecular weight based on Dynamic Light Scattering (DLS).

• • What Does Glycosylation Impurities Detect?

  Glycosylation impurities are a type of chemical commonly encountered in biochemical, medical, and pharmaceutical chemistry research. The presence of these impurities can affect the efficacy, safety, and stability of drugs. Therefore, the detection and analysis of glycosylation impurities are crucial in ensuring the quality and therapeutic effectiveness of pharmaceutical products.   What are Glycosylated Impurities?

• • LC-MS/MS Glycomics Analysis

  Glycomics is a crucial branch of biology dedicated to the study of the structure and function of sugar molecules within cells. Understanding this discipline is essential for revealing the relationships between cells and diseases. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a highly sensitive and accurate scientific technique, extensively used in glycomic research.   LC-MS/MS is a combination of liquid chromatography and tandem mass spectrometry.

• • Phosphorylation Analysis of Interacting Proteins

  Protein phosphorylation is one of the most important post-translational modifications in organisms, which has a crucial impact on the function, activity, and interaction of proteins. This article mainly discusses the role of phosphorylation in the analysis of interacting proteins.

• • Detection of Protein Alkylation Modifications

  Protein alkylation is a common post-transcriptional modification process that plays a significant role in biology. This modification involves the addition of alkyl groups (such as methyl and ethyl) to the amino acid residues of proteins, such as arginine, lysine, glutamic acid, etc. Alkylation modifications have a significant impact on the structure and function of proteins, including protein stability, interaction, and cellular localization.

• • Screening Antibodies by Single Cell Sequencing

  Researchers have long been striving to identify antibodies that can combat pathogenic microorganisms. However, traditional methods of antibody discovery require substantial time and effort and often fail to identify the most effective antibodies. In recent years, the advancement of single-cell sequencing technologies has offered a new possibility for the screening of antibodies.

• • Can Impure Proteins Be Sequenced?

  In biological experiments, protein sequencing is a critical technique that enables the determination of the amino acid sequence of proteins, thereby revealing their function and structure. However, a common question arises: is it possible to sequence impure proteins? This paper will explore this issue.   Importance of Protein Purity Firstly, let's understand why protein sequencing requires high purity proteins.

• • Methods for Detecting Residual Host Proteins

  The method of testing for host protein residues is to ensure the purity and safety of biopharmaceuticals. In the production process of biological drugs, host cell proteins (HCPs) produced by the production cells may remain in the final drug product, and the presence of these proteins may affect the safety and effectiveness of the drug. Therefore, pharmaceutical companies need to adopt effective methods to detect and quantify the residues of these host proteins.

• • Dynamic Light Scattering Particle Size Analysis

  Dynamic Light Scattering (DLS) is a technique for assessing the dynamic behavior of particulate matter in solution. This technique is mainly aimed at particles on the nanometer to micron scale, and obtains particle size distribution by measuring the Brownian motion of particles in solution.   The basic principle of DLS is to scatter laser light onto the particle surface, and the particles move randomly and irregularly in Brownian motion, causing the intensity of scattered light to fluctuate over time.