Resources

• How to Interpret Enriched Peptides in Autoantibody Studies

A practical guide to interpreting enriched peptides in autoantibody studies, covering normalization, control contrast, protein mapping, PTM context, and confidence tier assignment.

• How PhIP-Seq Supports Candidate Autoantigen Discovery

A technical guide explaining how PhIP-Seq supports candidate autoantigen discovery through library screening, enrichment analysis, protein mapping, and structured validation handoff.

• PhIP-Seq for Autoantibody Profiling

A technical overview of PhIP-Seq for autoantibody profiling covering workflow steps, library design, data outputs, applications, and validation planning.

• Serum vs Plasma vs CSF for Autoantibody Profiling

A comparison guide to serum, plasma, and CSF for autoantibody profiling covering matrix differences, study goal selection, handling requirements, and workflow implications.

• How to Prioritize Candidate Autoantigens after PhIP-Seq

A practical guide to prioritizing candidate autoantigens after PhIP-Seq using filtering, ranking criteria, tiered validation, and orthogonal confirmation workflows.

• Can PhIP-Seq Detect Conformational or Modified Autoantigens?

A technical guide explaining whether PhIP-Seq can detect conformational or modified autoantigens, covering library design limits, PTM variant screening, and validation paths for autoimmune serology.

• Planning a Polyclonal Antibody Sequencing Project: Sample Requirements, Reference Data, and Validation Strategy

Plan a polyclonal antibody sequencing project by addressing sample purity, reference data integration, and validation tiers before MS analysis begins.

• Before Choosing a Protein Mass Spectrometry Service: Sample, Data, and Reporting Questions to Confirm

A structured checklist of sample, data, and reporting questions to confirm before selecting a protein mass spectrometry service provider.

• High Throughput MS Profiling

Learn how high throughput MS profiling supports proteomics, metabolomics, and lipidomics cohorts with standardized LC-MS workflows and reproducible outputs.

• Shotgun vs Targeted Mitochondrial Proteomics: How Do They Compare?

Mitochondria are the cellular powerhouses responsible for ATP production, regulation of apoptosis, and participation in metabolic signaling pathways. With advancements in mass spectrometry, mitochondrial proteomics has become a crucial tool for investigating cellular energy metabolism, neurodegenerative diseases, tumor metabolism, and drug mechanisms. In proteomics studies, researchers typically choose between two main strategies: the Shotgun (Global Proteome Scanning) Approach and the Targeted Approa......