Resources

Proteomics Databases



Metabolomics Databases

• • N- and C-Terminal Sequencing of Proteins

  N- and C-terminal sequencing of proteins refers to the determination of the amino acid sequences at both termini of a protein chain. These sequences critically influence the protein’s function, cellular localization, and post-translational modifications. Understanding a protein’s sequence is foundational for elucidating its structure and function. In functional studies, knowledge of the N- and C-terminal sequencing of proteins provides insight into cellular localization signals and interaction sites w......

• • Characterizing Metal Binding Sites in Proteins with X-Ray Crystallography

  Characterizing metal binding sites in proteins with X-ray crystallography is a powerful proteomics technique that provides atomic-level details about the roles and mechanisms of metal ions in biomolecules. By analyzing the three-dimensional structures of protein crystals, this method identifies the locations of metal ions and their interactions with surrounding ligands. Such insights are invaluable for understanding the functions of metal ions in catalytic activity, structural stability, and electron ......

• • Top-Down and Bottom-Up Proteomics

  Top-Down and Bottom-Up Proteomics represent two primary strategies in proteomic research, each offering distinct advantages and applications. Top-Down Proteomics involves the analysis of intact proteins using mass spectrometry, preserving the protein's natural state. This approach is particularly valuable for investigating post-translational modifications and protein isoforms. Conversely, Bottom-Up Proteomics entails the enzymatic digestion of proteins into peptides, which are then analyzed by mass sp......

• • Interactome Map

  The interactome map represents a comprehensive and systematic depiction of the interactions among various biomolecules, including proteins, nucleic acids, lipids, and metabolites, within an organism. By graphically representing these complex networks, it serves as a "map" that enables researchers to intuitively understand how biological processes and cellular functions are regulated through these molecular interactions. In recent years, this technology has garnered significant attention and applicatio......

• • Protein Identification and Characterization

  Protein identification and characterization are critical components of proteomics research, aimed at thoroughly analyzing the types, structural features, and functional information of proteins within biological samples. As the final products of gene expression, proteins engage directly in and regulate nearly all biological processes, with a complexity in type and function that far surpasses nucleic acids. The primary tasks in protein identification and characterization involve two main aspects: identi......

• • How to Interpret Dynamic Light Scattering Analysis Results

  Dynamic Light Scattering (DLS), also known as laser scattering or quasi-elastic light scattering, is a technique used to measure the Brownian motion of small particles and molecules in a fluid. This technique provides information on particle size, shape, and distribution.

• • E. coli Gene Knockout Service

  Service Features: 1. High Efficiency: Leveraging advanced biotechnological methods, we can efficiently and accurately knock out specific genes in Escherichia coli. 2. Precision: Our service allows for the precise knockout of target genes based on client specifications, ensuring no disruption to other gene functions. 3. Safety: Our technicians undergo rigorous training to ensure the safe execution of all experimental procedures.

• • Detection of Protein Redox Modifications

  Protein redox modification represents a crucial post-translational modification in living organisms, involving structural changes in proteins and functional regulation. This process has profound implications for diverse physiological and pathological mechanisms, highlighting the importance of studying and detecting protein redox modifications.

• • Nitrosation Protein Modification Site Identification

  Nitrosylation is a crucial post-translational modification of proteins that plays a significant role in various physiological and pathological processes, including cell differentiation, apoptosis, tumor development, and neurodegenerative diseases. Identifying nitrosylation sites is essential for elucidating its biological functions.

• • Ubiquitination Site Detection by IP-MS

  IP-MS is a powerful technique for identifying ubiquitination sites on proteins, combining immunoprecipitation (IP) with mass spectrometry (MS) to achieve precise identification. This method is particularly noted for its capacity to conduct detailed analyses of ubiquitination at specific protein sites, providing insights into the ubiquitination of individual or multiple proteins. Furthermore, when integrated with mass spectrometry, IP-MS enables the analysis of protein diversity, post-translational..........