Resources

• • Application and Prospects of Flow Mass Spectrometry in Protein Modification Research

  With the development of the field of biopharmaceuticals, research and development of protein drugs have become increasingly important. Protein modifications, as key factors in protein function and regulation, are of great significance for the research and clinical application of biopharmaceuticals. In protein modification research, flow cytometry-mass spectrometry (FC-MS) has emerged as an effective tool for exploring protein modifications.

• • Innovative Shotgun Proteomics Approach

  Proteomics, as a discipline studying the composition, structure, function, and interactions of proteins in organisms, has played a crucial role in the field of biomedicine. Shotgun proteomics, an important method in proteomics research, allows for high-throughput analysis of proteins in a sample, providing a wealth of protein information.

• • How to Reveal Protein Higher-Order Structures Using Mass Spectrometry?

  Protein is one of the most important biomacromolecules in organisms, and its tertiary structure determines its function and properties. Revealing the high-level structure of proteins is of great significance for drug development and treatment in the field of biopharmaceuticals. Mass spectrometry, as an efficient and accurate analytical method, plays an increasingly important role in the analysis of protein high-level structures.

• • How to Select the Best Protocol for IP-MS Analysis?

  Protein-protein interactions are a crucial mechanism for cellular regulation, playing a key role in the cellular processes and the development of diseases. Immunoprecipitation-mass spectrometry (IP-MS) analysis is a highly sensitive and efficient technique that helps scientists reveal protein-protein interaction networks.

• • How to Analyze Protein-Peptide Interactions Using IP-MS?

  With the continuous development of biopharmaceuticals, the study of protein-protein interactions has become a key to exploring biological activities within organisms. In the study of protein-protein interactions, immunoprecipitation followed by mass spectrometry (IP-MS) has become an important tool that can help us decipher the nature of protein-peptide interactions.

• • Membrane Proteomics Exploring Hidden Functions and Interactions in the Cell Membrane

  The cell membrane is a barrier that separates the internal and external environments of the cell. It not only maintains the integrity of the cell structure but also plays crucial roles in many biological processes. In addition to its traditional structure and functions, the cell membrane also harbors numerous hidden functions and interactions that are vital for cellular regulation and communication.

• • How to Use Label-Free Quantitative Proteomics to Reveal Molecular Mechanisms?

  Proteomics is an important technique in contemporary biomedical field which helps us to gain deeper insights into the complex molecular mechanisms within cells and organisms. Unlabeled quantitative proteomics is a key technology in proteomics, which allows for the quantitative analysis of protein abundance and expression levels, revealing the molecular mechanisms of biological processes and providing valuable information for biopharmaceutical development and disease treatment.

• • How Does Exosome Proteomics Identify Differentially Expressed Exosomal Proteins?

  Extracellular vesicles are a type of small membrane vesicles secreted by cells, containing abundant proteins, nucleic acids, and bioactive molecules. In recent years, the study of proteomics of extracellular vesicles has gained widespread attention.

• • Decoding the Relationship Between Glycosylation and Immune Function

  Glycosylation of antibodies refers to the carbohydrate-related modification process on antibody molecules. Glycosylation is an important regulatory factor for protein structure and function, particularly crucial for biotherapeutic antibodies in the field of proteomics.

• • How Does Glycomics Achieve Comprehensive Analysis and Quantification of Glycometabolism?

  Glycomics is a discipline that studies the structure and function of all sugar molecules in cells, tissues, or organisms. Similar to proteomics and genomics, glycomics plays an important role in the field of biopharmaceutical protein research. The structural diversity and widespread distribution of sugar molecules make a comprehensive analysis of glycolysis challenging, but the continuous development of glycomics analysis provides effective solutions for this goal.