Resources

Proteomics Databases



Metabolomics Databases

• • The Best Dilution Strategy for HCP Detection

  HCP (Host Cell Protein) is a protein impurity that may remain in the production process of biopharmaceuticals, originating from the host cells used for producing these drugs. The presence of HCP can potentially impact the safety, efficacy, and quality of the drugs, therefore requiring strict detection and control. Different HCP detection methods have varying sensitivities and specificities, thus the optimal dilution strategy may differ.

• • Antibody Drug Microflow Imaging Particle Analysis

  Antibody drugs are a class of biopharmaceuticals that utilize the immune system's mechanism of specific recognition and binding to specific targets in the body. They are widely used in the treatment of various diseases, such as cancer, autoimmune diseases, and infectious diseases. Due to their importance in clinical therapy, ensuring the quality, purity, activity, and safety of antibody drugs is crucial.

• • Analysis of Recombinant Protein Drugs with FcyRI/FcyRII/FcyRIII Interactions

  Recombinant protein drugs are protein products derived from animals and plants through biotechnological research and development, which possess certain biological activities and can prevent and treat human, animal, and plant diseases. Compared to small molecule drugs, recombinant protein drugs have advantages such as high activity, high specificity, and low toxicity, making them favored by researchers.

• • Analysis of Components of Antibody Drug Culture Medium

  Antibody drugs are a class of drugs that are artificially synthesized antibodies used to treat diseases by specifically binding to target molecules. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, and antibody drug conjugates. Antibody drugs have shown significant efficacy in treating various diseases, such as cancer, autoimmune diseases, inflammatory diseases, immunoregulation, and ophthalmic diseases.

• • Advantages and Disadvantages of Protein Complex Identification using MALDI-TOF-MS and ESI-MS

  Mass spectrometry (MS) is a powerful analytical tool that plays a crucial role in identifying and characterizing protein complexes. Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF-MS) and Electrospray Ionization Mass Spectrometry (ESI-MS) are two commonly used MS techniques.

• • Mechanism of Protein Identification Using Shotgun Proteomics

  Shotgun proteomics is a powerful and high-throughput technique for the comprehensive analysis and identification of proteins in complex biological samples. This approach leverages mass spectrometry (MS) to analyze peptides derived from protein digestion, providing detailed insights into the proteome.

• • Principle of Membrane Protein Identification

  Membrane proteins are crucial components of cellular function, playing vital roles in processes such as signaling, transport, and cellular communication. Identifying and characterizing these proteins is essential for understanding their functions and the mechanisms of various diseases.

• • Workflow of Macromolecular Mass Measurement

  The accurate measurement of macromolecular mass is a fundamental task in various scientific disciplines, including biochemistry, molecular biology, and materials science. This process involves sophisticated techniques and meticulous workflows to ensure precise and reliable results.

• • Mechanism of Protein Complex Identification by Mass Spectrometry

  Mass spectrometry (MS) is an efficient and precise analytical technique widely utilized in proteomics research. It plays a pivotal role in the identification of protein complexes.

• • Workflow of Protein Complex Identification through MS

  Mass spectrometry (MS) is a highly sensitive and specific analytical technique widely used for the identification and quantification of protein complexes. Its core principle involves measuring the mass-to-charge ratio (m/z) of protein ions to obtain their molecular mass information and further elucidate protein structure and function. Below is a detailed workflow for identifying protein complexes using mass spectrometry: