Resources
Proteomics Databases
Metabolomics Databases
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• High-Performance Liquid Chromatography-Tandem Mass Spectrometry
High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) is a sophisticated analytical technique that integrates high-performance liquid chromatography (HPLC) with mass spectrometry (MS) to separate, identify, and quantify target molecules in complex samples. HPLC is utilized for the efficient separation of diverse components within a sample, while MS provides highly sensitive and selective detection through ionization and analysis of the mass-to-charge ratio (m/z) of molecules. Ta......
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Native mass spectrometry is a critical analytical technique for investigating the complex structures and interactions of proteins. Unlike traditional denaturing mass spectrometry, this approach avoids using harsh conditions, such as strong acids, strong bases, or elevated temperatures, which can disrupt the tertiary structure of proteins. This allows researchers to examine proteins and their complexes in a state close to their natural physiological conditions. Native mass spectrometry is widely applie......
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Computational proteomics is a field that integrates bioinformatics, statistics, and computer science with experimental data to analyze, interpret, and predict proteomic characteristics. As high-throughput technologies evolve, the scale and complexity of proteomic studies have expanded, leading to increasingly large and complex datasets. To efficiently process these data and extract significant insights, computational proteomics employs algorithms and computational models, unveiling the structure, func......
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• Advances in Exosome Proteomics Research
Exosome proteomics has emerged as a rapidly advancing field, focusing on the precise quantification and analysis of proteins within exosomes. These small vesicles, secreted by cells and measuring 30 to 150 nanometers in diameter, carry an array of biomolecules, including proteins, RNA, and lipids, and are prevalent in bodily fluids such as blood, urine, saliva, and milk. Exosomes play crucial roles in intercellular communication and are involved in various physiological processes, including immune res......
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LC-MS/MS analysis protein is a powerful technique for identifying and quantifying proteins in complex biological samples. This method combines liquid chromatography (LC) for separating complex mixtures into individual components with mass spectrometry (MS) to measure the mass-to-charge ratio (m/z) of these components. Through collision-induced dissociation (CID) or other fragmentation techniques, secondary ions are generated, providing detailed peptide sequence information for accurate protein sequenc......
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LC-MS/MS service integrates liquid chromatography and mass spectrometry for precise compound separation and molecular analysis. This methodology is extensively applied in proteomics, metabolomics, and pharmaceutical research within the life sciences. By leveraging liquid chromatography, the LC-MS/MS service effectively resolves compounds in complex biological samples, while tandem mass spectrometry provides high sensitivity and resolution for both qualitative and quantitative molecular assessments. Th......
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Pharmacokinetics analysis studies how drugs move through and are processed by the body, focusing on absorption, distribution, metabolism, and excretion. This type of analysis helps us understand how drug concentrations change over time within the body, allowing us to predict their behavior and inform clinical practices. Widely used in drug development, clinical trials, and personalized medicine, pharmacokinetics analysis supports researchers in determining optimal dosages and administration strategies......
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• Affinity Selection Mass Spectrometry
Affinity selection mass spectrometry (ASMS) is a sophisticated analytical technique that integrates affinity chromatography with mass spectrometry to identify and quantitatively evaluate interactions between biomolecules. Affinity Selection Mass Spectrometry employs specific affinity ligands-such as antibodies, peptides, or small molecules-to selectively capture target proteins or other biomolecules, followed by their identification using mass spectrometric analysis. This technique is pivotal in drug ......
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• Post-Translational Modification Mass Spectrometry
Post-Translational Modification Mass Spectrometry is a highly sensitive and precise technique used to identify and quantify modifications in proteins. Post-Translational Modification occur at specific sites after protein synthesis, through enzymatic or non-enzymatic reactions, and include modifications such as phosphorylation, acetylation, methylation, glycosylation, and ubiquitination. These modifications play critical roles in altering protein structure, stability, activity, and localization, thereb......
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• Mass Spectrometry for Post-Translational Modifications
Mass spectrometry for post-translational modifications (PTMs) is an efficient tool that utilizes mass spectrometry technology to accurately identify and quantify protein mass spectrometry for post-translational modifications (PTMs). These modifications occur on specific amino acid residues after protein synthesis, either via enzymatic or non-enzymatic mechanisms, and include processes such as phosphorylation, acetylation, methylation, glycosylation, and ubiquitination. Mass spectrometry for post-trans......
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