Resources

Proteomics Databases



Metabolomics Databases

• • Protein Conformation

  Protein conformation refers to the specific three-dimensional folding and shape of a protein molecule. Proteins are long-chain molecules formed by amino acids linked through peptide bonds. These chains spontaneously fold into distinct three-dimensional structures within cells or extracellular environments. The folding process is driven by the intrinsic properties of the amino acid sequence and influenced by environmental factors. The stability and accuracy of protein conformation are critical for nor......

• • Droplet Sequencing

  Droplet sequencing is a high-throughput sequencing technology that enables single-cell or single-molecule analysis within small droplets, significantly enhancing sequencing sensitivity and resolution. It has broad applications in biomedical research, particularly in oncology, immunology, and developmental biology. By analyzing gene expression at the single-cell level, researchers can precisely characterize tumor heterogeneity and identify rare cell populations and drug-resistant cells in cancer. In i......

• • High Throughput Drug Discovery

  High throughput drug discovery (HTDD) is a technology designed to rapidly screen large compound libraries to identify potential drug candidates. The key to this technology is the use of automated experimental systems, miniaturized assay techniques, and advanced data analytics, which allow researchers to test thousands of compounds for biological activity with high speed and precision. Traditional drug discovery methods typically require years of research and substantial financial resources. In contra......

• • High Throughput Screening Drug Discovery

  High throughput screening drug discovery (HTS) is a technology that uses automation and miniaturized experimental techniques to rapidly evaluate large libraries of compounds, assessing their effects on specific biological targets. The primary purpose of HTS is to swiftly identify promising drug candidates, thereby accelerating the drug discovery process. In traditional drug discovery, researchers must evaluate the biological activity of compounds individually, a process that is time-consuming, labor-......

• • Antibody Drug Discovery

  Antibody drug discovery refers to the process of researching and developing novel antibodies for the treatment of various diseases. Antibodies are proteins produced by B cells that specifically bind to distinct antigens, neutralizing pathogens or marking them for immune system recognition. The primary goal of antibody drug discovery is to harness the specificity and high affinity of antibodies to develop drugs capable of precisely targeting diseased cells or pathogens. Compared to traditional small-m......

• • Small Molecule Drug Discovery

  Small molecule drug discovery refers to the process of identifying, optimizing, and developing small molecules with therapeutic potential using scientific methods and technologies. Small molecules typically have a low molecular weight (usually less than 900 Daltons), which allows them to easily penetrate cell membranes and bind to intracellular targets, thereby exerting their therapeutic effects. The process of small molecule drug discovery generally involves several stages, including target identifi......

• • Isotope Labeling

  Isotope Labeling is a powerful technique for introducing stable isotopes into biomolecules, enabling the investigation of dynamic changes and interactions in proteins, metabolites, and other biological molecules. In proteomics, isotope labeling is widely employed to quantify protein expression, analyze post-translational modifications, and trace metabolic pathways. By labeling proteins in distinct samples (e.g., treatment and control groups), this method allows for precise differentiation and quantif......

• • Single-Cell Metabolomics

  Single cell metabolomics refers to a scientific discipline that employs highly sensitive analytical techniques to investigate the metabolite composition and dynamic changes within individual cells. Unlike traditional metabolomics, which typically analyzes the average metabolic profile of a cell population, single cell metabolomics focuses on the metabolic state of individual cells. This approach enables a more precise understanding of cellular metabolic activity, reveals heterogeneity among cells, an......

• • PROTAC

  PROTAC (Proteolysis-targeting chimeras) is an innovative drug development strategy that uses the cell’s natural proteasomal degradation mechanism to selectively degrade target proteins, as opposed to traditional inhibition methods. This strategy overcomes the limitations of small molecule inhibitors, which are often restricted to targeting active sites and have difficulty addressing non-catalytic regions, thus offering a new approach for targeting "undruggable" proteins. The mechanism of PROTAC actio......

• • Accurate Mass Spectrometry

  Accurate mass spectrometry is a high-resolution and high-mass-accuracy technique used for precise molecular mass measurement and in-depth analysis of complex sample components. The core of accurate mass spectrometry is based on high resolution and mass accuracy, achieved with advanced mass analyzers like Fourier transform ion cyclotron resonance mass spectrometers (FT-ICR MS) and Orbitrap mass spectrometers. Mass resolution refers to the ability to distinguish ions with similar masses, while mass acc......