Resources
Proteomics Databases
Metabolomics Databases
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• Mass Spec Protein Quantification
Mass spec protein quantification is a technique based on mass spectrometry for quantitative analysis of proteins in biological samples. It finds extensive applications in proteomics, drug development, disease biomarker discovery, and molecular mechanism studies. Compared to traditional protein quantification methods like ELISA and Western Blot, mass spectrometry offers high throughput and broad coverage, allowing for simultaneous absolute or relative quantification of thousands of proteins. It also pr......
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Multiplex proteomics is a high-throughput proteomic strategy that utilizes mass spectrometry to identify and quantify thousands of proteins across multiple samples in a single experiment. This technique employs chemical or isotopic labeling methods, such as Tandem Mass Tag (TMT) and Isobaric Tags for Relative and Absolute Quantification (iTRAQ), to label proteins or peptides uniquely in each sample. These labeled samples are then mixed and analyzed in a single mass spectrometry workflow, allowing for ......
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• Mass Spectrometry Fingerprinting
Mass Spectrometry Fingerprinting is an advanced method leveraging mass spectrometry for both qualitative and quantitative analysis of biomolecules. By examining the mass-to-charge ratio (m/z) obtained from mass spectrometric data, this technique accurately identifies and quantifies diverse molecules within a sample. Widely utilized in biochemistry, pharmacology, and clinical diagnostics, mass spectrometry fingerprinting offers key advantages such as high sensitivity and specificity, enabling the analy......
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• Oligonucleotide LC-MS Analysis
Oligonucleotide LC-MS analysis is a powerful analytical technique used to separate and identify oligonucleotides. Oligonucleotides are short chains of nucleic acids consisting of a limited number of nucleotide units. The fundamental principle of liquid chromatography relies on the differential retention of oligonucleotides across stationary and mobile phases with varying chemical properties. By adjusting the composition and gradient of the mobile phase, effective separation of oligonucleotides can be ......
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Tandem MS/MS analysis is a highly sensitive and specific analytical technique that is extensively used in fields such as proteomics, metabolomics, environmental science, pharmaceutical analysis, and clinical diagnostics. This method extends the capabilities of traditional mass spectrometry (MS) by providing precise identification, quantification, and structural analysis of target molecules in complex samples. The process involves multiple stages of mass analysis, where molecular ions are fragmented, s......
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• Single-Cell Whole Genome Sequencing
Single-cell whole genome sequencing is a cutting-edge technology that enables comprehensive sequencing and analysis of an individual cell's entire genome. Unlike homogeneous cell groups, biological systems consist of diverse cells with distinct functions. This technology empowers scientists to conduct detailed analyses on single cells, thus providing deeper insights into the diversity and dynamic changes of complex biological systems. In biomedical research, single-cell whole genome sequencing is pivo......
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ICP chemical analysis is an advanced analytical technique that enables high-sensitivity, quantitative detection of a wide range of elements through high-temperature plasma. Known for its exceptional sensitivity, accuracy, and versatility, ICP chemical analysis is a cornerstone of modern analytical chemistry. The technology generates a high-temperature environment via an inductively coupled plasma (commonly argon), which excites the atoms or ions of various elements in the sample to specific energy st......
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• 16S rRNA Sequencing Bacterial Identification
16S rRNA sequencing bacterial identification is a molecular biology-based method for classifying and identifying microorganisms. By analyzing the specific sequences of the bacterial 16S rRNA gene, scientists can efficiently and accurately identify microbial populations. The 16S rRNA gene is a conserved ribosomal RNA sequence, stable in its molecular structure across evolution, and is present in nearly all bacteria. Its length is approximately 1500 base pairs. Regions of this gene, such as the V3-V4 r......
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Single cell transcriptomics refers to the technique of analyzing gene expression at the single-cell level using sequencing technologies. This method captures the mRNA molecules from individual cells and converts them into sequencing data, offering an accurate representation of the gene expression profile within each cell. The advent of single cell transcriptomics addresses the challenge of cell-to-cell heterogeneity, which is often masked by the averaging effects seen in traditional transcriptomics a......
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• MALDI-TOF Bacteria Identification
Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Bacterial Identification (MALDI-TOF bacteria identification) is an efficient technique based on protein mass spectrometry fingerprinting for microbial identification. By analyzing the mass-to-charge ratio (m/z) of specific proteins within microorganisms, it enables the rapid and accurate identification of bacteria, fungi, and other microbes. Unlike traditional methods, such as culturing and molecular biology techniques, MALD......
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