Resources

Proteomics Databases



Metabolomics Databases

• • Immunoprecipitation Combined with Mass Spectrometry Analysis

  Immunoprecipitation combined with mass spectrometry analysis is a widely employed technique in proteomics that enables the identification of components within protein complexes and the characterization of protein–protein interactions. By leveraging the high specificity of immunoprecipitation and the high sensitivity of mass spectrometry, this approach facilitates the detection of proteins from complex biological samples. The workflow of immunoprecipitation combined with mass spectrometry analysis gene......

• • Applications and Method Development of High-Resolution Mass Spectrometry in Proteomics

  The application of high-resolution mass spectrometry in proteomics is primarily demonstrated by its ability to precisely measure the mass of proteins and peptides. This capability allows scientists to achieve highly sensitive and accurate identification of proteins and peptides, thereby playing a critical role in proteomics research.   Principles and Technological Advancements of HRMS 1. Improvement of Mass Resolution HRMS enables the distinction of mass peaks that are extremely close in m/z values, w......

• • Cryo-EM Single Particle Analysis in Structural Biology

  Cryo-EM single particle analysis is an advanced structural biology technique that enables the determination of three-dimensional structures of biological macromolecules in a near-native state. This method involves rapidly vitrifying samples at cryogenic temperatures to preserve their natural conformation in an amorphous, non-crystalline form, allowing direct visualization of individual molecules without the need for staining or crystallization. Using large datasets of molecular images, researchers app......

• • Crystallography Analysis

  Crystallography analysis is a critical technique for investigating the internal structure and atomic arrangement of materials. It plays a pivotal role across a range of disciplines, including chemistry, materials science, life sciences, and pharmaceutical development. By applying crystallography methods, researchers can determine crystal structures, bond lengths, bond angles, and intermolecular interactions with high precision. This structural insight is essential for understanding material properties......

• • Antibody Amino Acid Sequence

  The antibody amino acid sequence represents the linear order of amino acids that constitute the antibody protein and serves as the fundamental blueprint for determining both its structural architecture and functional properties. Antibodies, or immunoglobulins, are highly specific proteins secreted by B cells that recognize and bind to antigens, exerting a range of immune defense activities such as neutralization, opsonization, and immune system activation. This sequence not only governs antigen recogn......

• • High-Throughput Antibody Screening

  High-throughput antibody screening refers to the use of automated systems and advanced bioanalytical techniques to rapidly identify high-affinity antibodies against specific targets from large-scale antibody libraries. Unlike traditional methods such as hybridoma generation or phage display, which are often labor-intensive and time-consuming, this approach significantly enhances screening speed and throughput, thereby facilitating the accelerated development of therapeutic and diagnostic antibodies.  ......

• • Proteolysis Targeting Chimeras (PROTACs)

  Proteolysis targeting chimeras (PROTACs) are a class of bifunctional small molecules designed to induce selective degradation of specific proteins. Unlike traditional small-molecule inhibitors that act by occupying the active sites of target proteins, PROTACs hijack the endogenous ubiquitin–proteasome system to label target proteins for degradation, thereby eliminating their function at the source. This approach opens new avenues for tackling previously undruggable targets, including non-enzymatic pro......

• • End-Group Analysis of Polymer

  End-group analysis of polymer is a critical analytical technique for investigating polymer molecular structures, elucidating reaction mechanisms, and characterizing material properties. End-groups, the chemical functionalities located at the termini of polymer chains, play a pivotal role in polymerization processes, degradation behaviors, and the performance of polymeric materials. Precise end-group analysis of polymer enables researchers to infer polymerization mechanisms, regulate polymer molecular ......

• • Mass Spectrometry Flow Cytometry

  Mass spectrometry flow cytometry has emerged as a powerful analytical tool for dissecting cellular functions. Recently, this technique has been extensively applied in fields such as immunology, oncology, stem cell research, and drug development. In immunological research, mass spectrometry flow cytometry precisely characterizes the diversity and functional status of immune cells, enabling researchers to elucidate the mechanisms underlying complex immune responses and deepen the understanding of dynami......

• • DSC Chemical Analysis

  DSC chemical analysis is a vital analytical technique for investigating the thermal properties of materials, with extensive applications in protein research, drug development, polymer characterization, and food science. The fundamental principle of DSC chemical analysis involves comparing the differences in heat flow between a sample and a reference material under identical temperature conditions. During experiments, samples and reference materials are placed into separate, sealed sample pans and scan......