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Proteomics Databases
Metabolomics Databases
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In the context of cellular life processes, proteins often do not attain full functionality immediately after synthesis. Many require post-translational modifications (PTMs) to regulate their structural stability, subcellular localization, molecular interactions, and biological activity. PTMs have emerged as a critical area in modern life sciences, with broad applications in elucidating disease mechanisms, validating drug targets, and discovering biomarkers. Research Challenges in Post-translational ........
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• Applications and Advantages of Mass Spectrometry in Single Cell Proteomics
Life sciences research is increasingly focusing on the single-cell level, with single-cell proteomics (SCP) emerging as a critical approach for elucidating cellular heterogeneity and dissecting complex biological processes. Although single-cell transcriptomics is widely applied, the lack of consistent correlation between mRNA abundance and protein expression underscores the importance of direct protein-level measurements for accurately capturing cellular functional states. Mass spectrometry (MS), as a .....
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• Single-Cell Proteomics Analysis: Methods and Key Technologies
In modern life science research, understanding cellular heterogeneity is crucial for elucidating disease mechanisms, developing precision therapies, and reconstructing tissue developmental trajectories. While single-cell RNA sequencing has provided abundant insights at the transcriptional level, proteins, as the direct executors of cellular functions, more accurately capture the physiological states of cells. Consequently, Single-Cell Proteomics (SCP) has emerged as a key technology for investigating cell..
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• Cell Surface Proteomics Analysis
Cells constitute the fundamental units of biological activity, and their surfaces serve as the primary interface for sensing, recognizing, and responding to the external environment. Cell surface proteins are extensively involved in processes such as signal transduction, molecular transport, cell recognition, and adhesion, functioning as critical bridges that connect the intracellular and extracellular environments. Cell Surface Proteomics enables the systematic investigation of alterations in these .......
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• Single-Cell Proteomics: A Key Technology for Revealing Cellular Heterogeneity
In multicellular organisms, although cells share nearly identical genomes, they differ markedly in morphology, function, and fate. This phenomenon, referred to as cellular heterogeneity, lies at the core of complex biological processes such as development, disease progression, and drug response. To gain a deeper understanding of this heterogeneity, researchers have progressively transitioned from population-averaged measurements to multi-omics analyses at single-cell resolution. Among these advances........
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• Recent Advances in PTMs Analysis Techniques: A Comparison of Mass Spectrometry and Other Methods
Protein post-translational modifications (PTMs) serve as essential regulators of cellular homeostasis, signal transduction, and gene expression. The rapid advancement of proteomics has positioned PTMs analysis at the forefront of biomedical research, offering valuable insights into disease mechanisms, biomarker discovery, and the development of targeted therapies. To achieve precise characterization of these modifications, researchers continue to refine analytical approaches, with mass spectrometry (MS)....
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• How Do Protein Modifications Control Cellular Signaling? Core Mechanisms Analysis
Proteins are among the most functionally diverse biomolecules in cells, and their biological activity is largely regulated by post-translational modifications (PTMs). Within the cellular signaling network, PTMs not only regulate the conformation, stability, localization, and interactions of proteins but also precisely control the activation and termination of signals, thereby enabling cells to dynamically respond to external stimuli and precisely regulate cellular processes. Post-Translational ........
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Post-translational modifications (PTMs) play a pivotal role in the regulation of various biological processes, including signal transduction, metabolic regulation, epigenetics, and immune responses. As proteomics technologies have evolved, mass spectrometry (MS) has emerged as a critical tool for analyzing PTMs. Initially used for qualitative detection, MS has now progressed to high-throughput, reproducible quantitative analysis, demonstrating unparalleled capabilities in PTM research. Why Is Mass .........
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Cancer is a highly heterogeneous disease characterized by regulatory alterations across the genome, transcriptome, and proteome. In recent years, post-translational modifications (PTMs)—which govern protein function, stability, subcellular localization, and intermolecular interactions—have emerged as central themes in cancer research. While traditional proteomics has identified numerous differentially expressed proteins, it remains limited in dissecting functional regulatory networks and pinpointing .......
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• How Do Post-Translational Modifications Affect the Biological Functions of Proteins
Proteins serve as the central executors of various cellular processes. However, they are not functionally active immediately after translation. Instead, they typically undergo a series of precisely regulated post-translational modifications (PTMs). These modifications profoundly influence protein structure, functional properties, and intracellular fate. This article explores how post-translational modifications modulate protein functions, highlighting regulatory mechanisms, underlying molecular principles..
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