Resources
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Custom peptides are synthesized peptide sequences tailored to specific research objectives or application requirements. These peptides can be precisely designed in terms of length, amino acid sequence, and chemical modifications to address specific scientific or industrial challenges. In medical research, custom peptides have broad applications, including vaccine development, antibody production, and drug target validation. Through rational design and synthesis, they can emulate the functional propert......
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Biomarker discovery involves identifying and validating substances or molecules within organisms using a variety of technical approaches. These molecules can serve as indicators of normal biological or pathological processes or as markers for therapeutic responses. Biomarkers may include DNA, RNA, proteins, metabolites, or even cell populations. Among these, proteomics-based mass spectrometry has emerged as an essential tool in biomarker discovery. In the medical field, biomarkers have transformed the......
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• Advancements in Peptide Synthesis Methods Applications and Innovations
Peptide synthesis refers to the chemical or biological assembly of amino acids in a defined sequence to form peptide chains. Peptides, typically composed of 50 or fewer amino acid residues linked by peptide bonds, are ubiquitous in living organisms and serve critical biological functions. Key roles include acting as hormones, neurotransmitters, immune regulators, and antimicrobial agents. Their small size enables peptides to play indispensable roles in cellular signaling, immune modulation, and growth......
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Target identification refers to the process of determining the interaction between a drug or molecule and a specific biological target, such as a protein or nucleic acid, within an organism. As a central element in biological mechanisms, target identification is pivotal in uncovering the action mechanisms of drugs in cells, tissues, or organs, thereby facilitating the development of novel therapeutics, precision medicine strategies, and a deeper understanding of disease pathogenesis. This methodology ......
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Single molecule sequencing (SMS) is an innovative technology that focuses on analyzing individual molecules, offering a distinct advantage over traditional population-based sequencing methods. By enabling real-time monitoring of single molecules, SMS eliminates the need for PCR amplification or DNA/RNA fragmentation, thus avoiding biases and errors associated with amplification processes. This precision makes it particularly suitable for studying complex genomes, rare mutations, and epigenetic modific......
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• Selected Reaction Monitoring
Selected Reaction Monitoring (SRM) is a mass spectrometry-based quantitative technique extensively utilized in proteomics research. By targeting specific precursor ions and their corresponding product ions, SRM achieves exceptional sensitivity and specificity in detecting analytes. Initially developed for small molecule analysis, its application has expanded significantly due to its robustness in quantifying components within complex biological samples. In proteomics, Selected Reaction Monitoring is a......
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Isotope labeling-based relative and absolute quantification (iTRAQ) is a technique that enables the relative and absolute quantification analysis of multiple samples through isotope labeling. The core of iTRAQ technology lies in using chemical labeling reagents to label proteins. These reagents react with the N-terminus of peptide chains and the side chain of lysine, creating a unique labeling pattern that allows the same peptide to be distinguished and quantified by mass spectrometry across different......
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• De Novo Peptide Sequencing in Proteomics Applications
De novo peptide sequencing is a technique used to directly infer the amino acid sequence of unidentified peptide fragments from mass spectrometry data. Unlike traditional database search methods, it does not rely on pre-existing protein sequence databases. Instead, it derives peptide sequences by analyzing the fragmentation patterns of ions present in the mass spectrometry data. This technology plays a pivotal role in proteomics research, particularly for investigating newly discovered proteins, speci......
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Chemoproteomics is an interdisciplinary field that integrates chemical tools with proteomics techniques, aiming to provide a comprehensive analysis of protein structure, function, and their interactions with small molecules. The core principle of chemoproteomics involves using chemical probes or reactive molecules to specifically label proteins or their modification sites, which can then be detected using high-throughput techniques such as mass spectrometry. These labels enable the analysis of related......
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• Dynamic Light Scattering Service
Dynamic light scattering service is a specialized analytical technique used for particle analysis, relying on dynamic light scattering (DLS) technology. This service is widely applied in the determination of particle size distribution and molecular dynamics studies, particularly for nanomaterials, biomolecules, and other particulate systems. The dynamic light scattering service has become an indispensable tool due to its simplicity, speed, and high sensitivity, especially when investigating nanopartic......
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