Resources

Proteomics Databases



Metabolomics Databases

• • Proteomics & Metabolomics Fusion: Holistic Insight into Biological Systems

  The biological system is a complex and intricate network, in which proteins and metabolites play important roles. Proteomics and metabolomics, as two important fields of omics, provide a new perspective for deciphering the biological system through the study of proteins and metabolites. This article will delve into the integration of proteomics and metabolomics, as well as their applications in the comprehensive interpretation of biological systems.

• • Bioinformatics Fusion: New Breakthroughs in Proteomics and Metabolomics

  The field of biopharmaceutical research has been continuously evolving, and scientists have adopted multi-omics approaches to gain a better understanding of complex biological processes within organisms. Among these approaches, proteomics and metabolomics are two important research areas. In recent years, the breakthroughs in the combined analysis of proteomics and metabolomics have attracted widespread attention.

• • Using De Novo Sequencing and Protein Identification Techniques to Study the Novel Anti-NSCLC Protein PFAP

  Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for approximately 85% of lung cancer cases. At the same time, over 30% of NSCLC patients are diagnosed with advanced stage disease. However, despite the current existence of radiotherapy, chemotherapy techniques, and new adjuvant immunotherapies, the survival rate for advanced NSCLC patients has not yet reached the desired level of effectiveness.

• • Common Methods for Protein SUMOylation Detection

  Protein SUMOylation is a vital post-translational modification process, involving the covalent binding of small ubiquitin-like modifier (SUMO) to the target protein. SUMOylation plays a crucial role in many biological processes, such as nuclear transport, transcriptional regulation, cell cycle progression, and stress response.

• • Proteomic Phosphorylation Overview

  Protein Phosphoproteomics is a scientific field that studies protein phosphorylation at a proteome-wide level. It is not merely the analysis of phosphorylation sites of a single protein or a few proteins, but aims to comprehensively identify and quantify the phosphorylation states of all proteins in cells, tissues, or organisms.

• • Amino Acid Sequencing: Principles, Techniques, and Applications

  When we talk about DNA sequencing, people often think of genes, heredity, and the origins of life. However, amino acid sequencing is the real bridge that translates this DNA information into actual functions. Every protein in an organism is composed of amino acids, and the specific sequence of amino acids determines the shape and function of the protein. Therefore, understanding the amino acid sequence of proteins is crucial for biological research.

• • The Hierarchy and Determination Methods of Protein Structure

  The structure of proteins is a core area of biomolecular research because their structure is closely related to their function. The structure of proteins is usually divided into four levels: primary structure, secondary structure, tertiary structure, and quaternary structure.   Primary Structure 1. The primary structure describes the amino acid sequence of the protein. 2. This continuous chain of amino acids is connected through peptide bonds.

• • Protein N-terminal and C-terminal Sequencing Methods Analysis

  Protein N-terminal and C-terminal sequencing are methods of analyzing the arrangement of amino acids in protein sequences, especially the starting and ending positions of the sequence. This sequencing can provide important information about the origins, structure, and functions of the protein.   N-terminal Sequencing (Edman Degradation) Edman degradation is a classic method of protein N-terminal sequencing.

• • The Technology and Application of Peptide Sequence Determination

  Peptide sequencing is the process of determining the exact arrangement of amino acids in a peptide or protein. This process is crucial for protein function research, disease mechanism analysis, drug design, and other fields.   Peptide Sequencing Techniques 1. Edman Degradation This method determines the sequence by sequentially removing the amino acid at the N-terminus of the peptide and measuring each released amino acid, one amino acid at a time, suitable for short peptide sequences.

• • Protein Sulfonic Acid Modification Detection

  Protein sulfonic acid modification is a less common but very important kind of protein post-translational modifications. It involves the addition of a sulfate group to specific amino acid residues of a protein, usually tyrosine residues. Unlike phosphorylation, sulfonation is a covalent, permanent modification.   Common methods for detecting protein sulfonation include: 1. Mass Spectrometry (MS) LC-MS/MS can be used to identify sulfonation sites due to the mass increase caused by sulfonation.