Resources

Proteomics Databases



Metabolomics Databases

• • TAILS Proteomics

  TAILS proteomics (Terminal Amine Isotopic Labeling of Substrates) is a high-resolution proteomic strategy designed to characterize the structural features of protein N-termini and to identify protease cleavage sites. This approach involves chemical labeling of protein N-terminal amines using isotopic reagents, followed by selective enrichment and mass spectrometry analysis, enabling sensitive and systematic detection of both native N-termini and neo-N-termini generated by proteolytic processing.

• • Detection Methods for Changes in Protein Glycosylation Levels

  Glycosylation is a crucial post-transcriptional modification process that influences the folding, stability, activity, and intercellular interactions of proteins. There are various methods to determine if the glycosylation modification level on a protein has changed, and each method has its characteristics and applicable scenarios. Here are some commonly used techniques: 1. Mass Spectrometry (MS) MS is a very powerful tool, especially when combined with liquid chromatography (LC-MS/MS)

• • Detection of Protein Phosphorylation Levels at Specific Sites

  Quantitative analysis of phosphorylation levels plays a crucial role in studying cell signaling, disease development, and drug mechanisms. The phosphorylation level at specific sites reflects the activity status of proteins and their involvement in biological processes.

• • Principles of Proteomics

  Proteomics is an important research field in the biopharmaceutical industry, which focuses on the study of the entire collection of proteins in an organism, helping us to gain deeper insights into the physiological and pathological processes of living organisms. Proteins are the most diverse and functionally rich molecules in living systems, and understanding the principles of proteomics is pivotal in exploring the molecular mechanisms within cells and organisms.

• • The Similarities and Differences in Histone Modifications in Glycosylation and Acetylation

  Within each tiny nucleus of our bodies, a multitude of different protein molecules are dancing together in the choreography of life. Some of them are histones, whose importance is undeniable. Histone modifications can impact the expression of billions of genes throughout the body, making them comparable to an orchestra within the nucleus.

• • Glycomics Unveiling the Full Scope of Glycan Modification Regulation

  Glycosylation, as an important protein modification, is a common regulatory mechanism in cells. Glycan modifications on proteins can regulate their structure and function, thereby affecting biological processes in organisms. Glycomics, as a significant branch in the exploration of protein modifications, aims to study glycan modifications on proteins.

• • CIq Affinity Measurement of Recombinant Protein Drugs

  Recombinant protein drugs refer to protein products derived from animals and plants through biotechnological research and development, which have certain biological activity and can prevent, diagnose, and treat human, animal, and plant diseases. Compared to small molecule drugs, recombinant protein drugs have advantages such as high activity, high specificity, and low toxicity, making them favored by researchers.

• • Quantitative Proteomics Analysis Empowering Biomedical Research

  Quantitative proteomics reveals the complex protein composition and regulatory networks in biological organisms by precisely measuring changes in protein abundance. This technology has brought about key breakthroughs in biomedical research, propelling advancements in areas such as disease diagnosis, drug development, and personalized medicine.

• • Methods and Significance of Protein Secondary Structure Analysis on Revealing Complex Proteins

  In the field of protein identification, protein secondary structure analysis is a crucial method that reveals the composition of complex proteins by deciphering their secondary structure elements.

• • Role of Protein Purity Analysis in Biopharmaceutical Development

  Protein purity refers to the proportion of the target protein in the preparation. Protein purity analysis becomes an essential step in biopharmaceutical development. High purity proteins not only enhance the stability and biological activity of drugs, but also reduce the risk of adverse reactions.