Resources

Proteomics Databases



Metabolomics Databases

• • Protein-Protein Interactions Pull-Down Assays

  Protein-protein interactions pull-down assays are biochemical techniques that utilize affinity enrichment principles to investigate the physical binding relationships between proteins within cellular environments. By mimicking protein binding states in vitro, these assays enrich target complexes, which are subsequently identified and qualitatively analyzed using various detection methods. This approach is instrumental in elucidating signaling pathways, regulatory networks, and functional complexes inv......

• • Visual Proteomics

  Visual proteomics represents a rapidly evolving interdisciplinary domain at the intersection of proteomics and vision science. It is dedicated to systematically elucidating the composition, function, regulatory mechanisms, and dynamic modulation of proteins in the visual system. As one of the most intricate and refined sensory systems in humans, vision depends on the coordinated activity of thousands of proteins across processes such as phototransduction, signal relay, energy metabolism, cellular ..........

• • Target Identification in Drug Discovery Process

  Target identification in drug discovery process constitutes a foundational step in modern drug development, serving as a critical prerequisite for ensuring that therapeutic agents exert their intended biological effects. A target refers to the specific molecular entity—typically a protein such as an enzyme, receptor, or ion channel—that a drug interacts with to modulate its activity or signaling, thereby altering cellular functions and influencing disease progression. Due to the inherent complexity of .....

• • Activity-Based Protein Profiling of the Serine Hydrolases

  Activity-based protein profiling of the serine hydrolases is an analytical approach that integrates enzyme-reactive probe chemistry with high-resolution mass spectrometry to investigate the expression patterns and functional states of serine hydrolase family members. Serine hydrolases are ubiquitous in both eukaryotic and prokaryotic systems, playing vital roles in digestion, immune regulation, development, and apoptosis. Their catalytic mechanism involves a conserved serine residue at the active site......

• • Target Identification and Validation in Drug Discovery

  Target identification and validation in drug discovery represent critical steps that determine the scientific foundation and strategic direction of pharmaceutical research and development. A “target” refers to a biomolecule—such as a protein, DNA, or RNA—that can bind to a drug and elicit a specific biological effect. In target identification and validation in drug discovery, identification involves the systematic selection of disease-relevant molecular targets using various analytical and computational....

• • Prostate Cancer Proteomics

  Prostate cancer proteomics refers to the application of proteomic technologies to systematically investigate alterations in protein expression profiles, regulatory mechanisms, and their associations with clinical features during the initiation and progression of prostate cancer. As a specialized branch within the field of prostate cancer research, prostate cancer proteomics employs large-scale protein quantification, post-translational modification (PTM) profiling, and protein interaction network ........

• • Production and Characterization of Adeno Associated Viral Vectors

  The production and characterization of adeno associated viral vectors constitute essential procedures in gene therapy research and development. AAV is a non-pathogenic virus capable of infecting a broad range of mammalian cells. Due to its low immunogenicity and lack of pathogenicity, it has emerged as one of the most promising viral vectors for gene delivery applications. Consequently, ensuring the rigorous production and thorough characterization of AAV vectors is critical for their therapeutic use.

• • High Throughput Chemical Screening

  High throughput chemical screening refers to a technology that enables the rapid evaluation of the biological activity or chemical properties of large numbers of compounds within a short period. By leveraging automation, miniaturization, and a variety of technical approaches, this method allows researchers to efficiently identify compounds with potential biological relevance. In drug discovery, HTS is extensively utilized during the initial screening phase for targeted therapeutics. With the support of.....

• • X-ray Structural Analysis

  X-ray structural analysis (X-ray crystallography) is a classical physical method that exploits the interaction between X-rays and crystalline materials to determine the three-dimensional structures of molecules. It is a cornerstone technique in structural biology, medicinal chemistry, and materials science. By obtaining high-quality crystals of target molecules and irradiating them with X-rays to collect diffraction patterns, researchers can reconstruct electron density maps and accurately derive atomic....

• • Single-Cell Bisulfite Sequencing

  Single-cell bisulfite sequencing is a high-throughput sequencing technique designed to assess DNA methylation at single-cell resolution. By integrating bisulfite conversion, single-cell isolation, and high-throughput sequencing, this technology can comprehensively map the genome-wide distribution of 5-methylcytosine (5mC) within individual cells. DNA methylation, a crucial epigenetic regulatory mechanism, plays significant roles in cell fate determination, embryonic development, gene expression regulation..