Resources
Proteomics Databases
Metabolomics Databases
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• Advancements in Protein Mass Measurement Techniques
Proteins are macromolecules composed of amino acids linked by peptide bonds, with molecular mass variations depending on their sequence and number of amino acids. The core objective of protein mass measurement is to precisely determine the mass of these biomolecules, enabling detailed insights into their structural and functional properties. This process relies on mass spectrometry, where samples are ionized to produce charged ions for analysis. By measuring the mass-to-charge ratio (m/z) of these ion......
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Protein molecular weight is one of the important indicators to understand the structure and characteristics of proteins. Mass spectrometry technology plays an important role in protein analysis, including commonly used mass spectrometry detection methods such as Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) and Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). In the process of protein mass spectrometry detection, sample processing and analysis me......
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• Exploring the Potential Applications of Protein Structure Analysis in the Field of Biomedicine
With the advancement of scientific technology, the potential application of protein structure analysis in the field of biomedicine is gradually revealed. Techniques for Protein Structure Analysis 1. X-ray Crystallography X-ray Crystallography is one of the most commonly used methods for protein structure analysis. By the X-ray diffraction patterns of protein crystals, scientists can determine the atomic structure of proteins, thereby revealing its functions and modes of interaction. 2. Nuclear Mag......
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Mass spectrometry is a powerful analytical technique based on the mass and structure of proteins. The core technical principle involves ionizing protein molecules from samples using a mass spectrometer, followed by separation, acceleration, and detection under high-vacuum conditions. The mass spectrometer generates a mass spectrum based on the mass-to-charge ratio (m/z) of the protein molecules, thereby providing detailed information on the protein’s mass, structure, and abundance. Common Mass Spect......
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• Exploring the Mystery of Protein Denaturation: Characterization Methods and Technological Analysis
Protein denaturation is one of the important regulatory mechanisms of protein structure and function. Through the characterization methods and techniques of protein denaturation, we can understand the changes and stability of protein structure and reveal the mysteries of protein structure. This is of great significance for drug development, protein engineering, and understanding protein function. Causes and Types of Protein Denaturation 1. Causes of Protein Denaturation Protein denaturation can be c......
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• Western Blotting Quantification
Western blotting quantification is widely applied in life sciences research, particularly in protein expression analysis, disease mechanism studies, and drug development. This technique relies on the interaction between antibodies and target proteins, enabling precise detection and quantification of the target protein expression levels in complex biological samples. It not only offers high specificity, but also provides critical data on protein function, post-translational modifications, and protein-p......
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Western blot analysis is a widely utilized technique in molecular biology, cell biology, and medical research, especially for the qualitative and quantitative analysis of proteins. This technique enables researchers to identify and quantify specific proteins' expression levels, revealing changes in physiological or pathological conditions. It combines the benefits of electrophoretic separation and antibody-based detection, offering a highly sensitive and specific method for protein analysis. The pri......
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• Cross Linking Mass Spectrometry
Cross linking mass spectrometry (XL-MS) has rapidly developed in recent years as a powerful technique in the field of proteomics. By combining chemical crosslinkers with mass spectrometry analysis, XL-MS provides researchers with an invaluable tool for investigating the three-dimensional structures and interactions of proteins and protein complexes. Unlike traditional methods such as X-ray crystallography or nuclear magnetic resonance (NMR), cross linking mass spectrometry offers a broader range of ......
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Cross linking mass spec (CLMS) is a powerful technique for investigating the spatial structure, interactions, and dynamic changes of proteins and protein complexes. By utilizing this approach, researchers are able to reveal the three-dimensional conformation of proteins, the interactions between subunits, and their cooperative functions in biological processes at the molecular level. This method combines the advantages of chemical cross-linkers and mass spectrometry analysis, playing an indispensable ......
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• Mass Spectrometry in Protein Identification
The application of mass spectrometry in protein identification continues to drive the forefront of developments in life sciences and biomedical research. As a highly sensitive and high-resolution analytical technique, mass spectrometry enables the precise identification and quantification of proteins, uncovering their structure, function, and roles within cells. By measuring the mass-to-charge ratio (m/z) of molecular ions, this technology provides researchers with a powerful tool to explore protein c......
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