Resources

Proteomics Databases



Metabolomics Databases

• • Glycosylation Sequencing

  Glycosylation is a common post-translational modification of biomolecules, involving the attachment of sugar molecules to other biomolecules such as proteins, nucleic acids, or lipids, thereby affecting their function and stability. Glycosylation sequencing is not just the process of identifying sugar chains, but rather a method for decoding the complex glycan structures on protein surfaces.

• • Glycated Collagen Protein Detection

  Collagen is the most abundant protein in tissues and organs, and glycated collagen refers to collagen that has undergone glycation modification. Glycated collagen is mainly present in multiple tissues of the human body, especially in tissues rich in collagen, such as skin, bones, joints, blood vessels, and other connective tissues. Under normal physiological conditions, glycation occurs as a natural biochemical process, but its extent is low.

• • What Protein Structures Can Be Ubiquitinated?

  Ubiquitination is a post-translational modification (PTM) of proteins that involves the addition of one or more ubiquitin proteins to a substrate protein. Ubiquitin is a small regulatory protein that can covalently bind to other proteins. Ubiquitination can impact protein degradation, localization, activity, and interactions between proteins. Understanding which protein structures can be ubiquitinated requires an understanding of the mechanisms and target characteristics of ubiquitination.

• • How to Detect Glycoproteins

  Glycoprotein detection is an important field in biochemistry and molecular biology because glycosylation is one of the most common and complex post-translational modifications of proteins in cell processes. Mass Spectrometry (MS) Mass spectrometry is one of the most powerful tools in glycoprotein analysis, especially in structural identification and analysis of complex glycan chains.

• • Application of Circular Dichroism in Protein Analysis

  Circular dichroism (CD) spectroscopy is a spectral technique used to analyze molecular structures, particularly suitable for studying the secondary structures of biomolecules such as proteins, nucleic acids, and peptides. It utilizes the difference in absorption of left-handed (counterclockwise) and right-handed (clockwise) circularly polarized light to obtain information about the structure of molecules.

• • HDX-MS: Unveiling Protein Structure and Dynamics

  Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS) is an advanced technique that combines hydrogen-deuterium exchange (HDX) and mass spectrometry (MS) for studying the dynamic structure and interactions of proteins and protein complexes. It provides information about protein secondary and tertiary structure, as well as details of protein dynamics, which are crucial for understanding protein function and protein-protein interactions.

• • Overpressure Solutions in Circular Dichroism Experiments

  The phenomenon of overpressure in Circular Dichroism (CD) experiments usually refers to the excessive pressure generated in the sample cell or system. This can lead to damage, leakage, or degradation of the sample cell, affecting the accuracy of the experimental results.

• • Lactoferrin Circular Dichroism Spectroscopy

  Lactoferrin is a naturally occurring protein found in mammalian milk, especially colostrum. It belongs to the transferrin protein family and its main function is to efficiently bind and transport iron ions. In addition, lactoferrin also exhibits a wide range of biological activities, including antimicrobial, antiviral, anti-inflammatory, and immune-regulating effects. These activities make lactoferrin important in the food industry, nutritional supplementation, and medical fields.

• • Significance of Host Cell Protein Residue Detection in Biopharma

  Host protein residual detection is an important quality control step in the biopharmaceutical process. In biopharmaceuticals, cell lines (hosts) are commonly used to produce proteins or other biological products. These cell lines can be bacteria, yeast, mammalian cells, etc. After the production process is completed, the product needs to undergo multiple purification steps to remove non-target impurities, including host cell proteins.

• • ICP-MS Trace Element Detection in Cardiac Tissue

  The heart tissue contains various trace elements such as magnesium (Mg), zinc (Zn), copper (Cu), selenium (Se), iron (Fe), and calcium (Ca), which play key roles in maintaining heart function and overall heart health. For example, Mg plays a role in maintaining normal heart rhythm, helping the myocardium relax, and preventing arrhythmia. It also participates in energy metabolism and electrolyte balance, which are crucial for heart function.