Resources
Proteomics Databases
Metabolomics Databases
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• Post-Translational Modification Proteomics: Unraveling Disease Mechanisms
Post-translational modification proteomics is the field that investigates various reversible and irreversible modifications occurring on proteins post-synthesis, facilitated by enzymatic activities or chemical reactions. These modifications significantly impact protein structure, stability, activity, subcellular localization, and interaction networks by adding or removing functional groups on amino acid residues. Serving as a regulatory mechanism for cellular processes, post-translational modification......
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• Proteomic Analysis of Post-Translational Modifications: Advancing Drug Development
Proteomic analysis of post-translational modifications is a scientific method used to investigate the chemical modifications proteins undergo after translation and their subsequent effects on protein function. Proteins serve as the primary molecular machinery executing numerous functions within organisms, and post-translational modifications (PTMs) provide a mechanism for the dynamic regulation of these functions. By adding or removing chemical groups such as phosphate, methyl, acetyl, or glycan, PTMs......
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• Plant Proteomics: Unlocking Molecular Mechanisms
Plant proteomics is the scientific study of all proteins within plant organisms, focusing on their composition, structure, function, and changes under varying physiological and environmental conditions. The rapid advancements in genomics and mass spectrometry technologies have made plant proteomics a powerful tool for delving into the molecular mechanisms underlying plant growth, development, metabolism, and environmental stress responses. The primary objective of this proteomic technology is to ident......
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Plasma proteome profiling involves the comprehensive study of plasma proteins, including their types, quantities, post-translational modifications, and dynamic alterations, utilizing high-throughput mass spectrometry and advanced bioinformatics. Plasma, as a bodily fluid, holds proteins from all body organs and tissues, making it an effective medium for reflecting physiological states and disease progression. Consequently, this analysis finds extensive applications in early diagnosis, exploration of p......
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• Parallel Reaction Monitoring Mass Spectrometry
Parallel reaction monitoring mass spectrometry is an advanced quantitative proteomics technique based on high-resolution and high-mass accuracy mass spectrometry, widely employed for the sensitive and specific detection of proteins or peptides. Originating from selected reaction monitoring (SRM), PRM utilizes high-resolution instruments such as the Orbitrap for analysis. Compared to SRM, parallel reaction monitoring mass spectrometry boasts superior specificity and resolution, enhancing the precise de......
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• Parallel Reaction Monitoring (PRM)
Parallel Reaction Monitoring (PRM) is a quantitative protein analysis method utilizing high-resolution mass spectrometry, applicable across diverse fields. In proteomics, Parallel Reaction Monitoring (PRM) enables precise quantification of target proteins, facilitating the understanding of complex biological processes. Within drug development, Parallel Reaction Monitoring (PRM) assists in monitoring drug metabolism, thereby enhancing drug design. In environmental monitoring, Parallel Reaction Monitori......
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Quinoa amino acids analysis is a scientific method used to determine the detailed amino acid composition of quinoa, often referred to as a "superfood." As a nutrient-dense, cereal-like crop, quinoa has garnered growing interest due to its high protein content and rich amino acid profile, particularly essential amino acids vital for human health. The goal of this analysis is to thoroughly identify the types and quantities of amino acids within quinoa, thereby assessing its nutritional value and potenti......
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• Peptide Sequence Analysis by Tandem Mass Spectrometry
Peptide Sequence Analysis by Tandem Mass Spectrometry is a powerful analytical tool employing multi-stage mass spectrometry techniques to characterize peptide molecules. Through MS/MS, scientists can elucidate peptide sequences within complex protein samples, thereby facilitating the study of protein biological functions, the identification of novel proteins, exploration of protein post-translational modifications, and the development of novel biomarkers. Biomarkers serve as molecular indicators of bi......
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Peptidomic analysis, a subdivision of proteomics, is dedicated to examining peptide molecules within biological samples. Peptides, typically consisting of 2 to 50 amino acids linked by peptide bonds, are crucial in various biological functions such as cellular signaling, immune responses, and hormone regulation. The primary objective of peptidomic analysis is to thoroughly investigate peptide sequences, concentrations, and modifications within biological samples, thereby uncovering their roles and dyn......
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PAGE Protein Analysis is a classical and widely implemented analytical technique for protein analysis. This method relies on the variable migration rates of proteins through a polyacrylamide gel under an electric field, effectively enabling the separation of proteins within a complex mixture. The fundamental principle underlying this technique is that a protein's migration speed in an electric field correlates with its molecular weight, shape, and charge density. Through PAGE Protein Analysis, researc......
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