Resources
Proteomics Databases
Metabolomics Databases
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protein expression profile is a pivotal technique for studying the types, quantities, and dynamics of proteins within an organism. By systematically analyzing proteins, this technique elucidates protein expression patterns under various physiological or pathological conditions. As the most diverse and functionally versatile molecules in cells, proteins play crucial roles in biological processes such as cell growth, differentiation, signal transduction, and immune response. Thus, understanding protein ......
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Protein profile analysis is an indispensable core technology in modern biological research. It employs a mass spectrometer to measure the mass-to-charge ratio (m/z) of proteins, thereby accurately analyzing their composition, structure, post-translational modifications, and interactions. As key molecules within cells, proteins are responsible for nearly all biological processes-including catalysis, structural support, and signal transduction-so protein profile analysis provides critical insights into ......
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• Protein and Peptide Mass Spectrometry in Drug Discovery
Protein and peptide mass spectrometry in drug discovery is a highly sensitive and precise technique widely employed throughout various stages of drug development. By measuring the mass-to-charge ratio (m/z), mass spectrometry reveals the chemical composition, structural features, and post-translational modifications of proteins and peptides. This technique is not only applied in drug screening and target validation but is also extensively used in studies of drug metabolism, toxicity, and clinical effi......
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Ligand identification is the process by which molecules that interact with biomacromolecules, such as proteins and nucleic acids, are recognized and confirmed using various methods and techniques. These ligands may include small molecule drugs, natural products, hormones, antibodies, or other chemical entities. By binding to biomacromolecules, ligands regulate their functions and play crucial roles in biological processes like cell signaling, metabolic pathways, and immune responses. This ligand-recep......
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• Protein Analysis by Shotgun Bottom-Up Proteomics: Advances and Applications
Protein analysis by Shotgun Bottom-Up proteomics is one of the two widely employed techniques in modern proteomics. It utilizes distinct approaches to comprehensively analyze proteins, enabling researchers to extract valuable insights from complex biological samples. The adoption of these methods has significantly advanced the field of proteomics, facilitating an in-depth biological understanding in diverse areas such as disease investigation, drug development, and nutrition. The Shotgun strategy ......
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• ICP-MS Quantitative Analysis
ICP-MS quantitative analysis is widely used in fields such as environmental science, geology, biomedicine, and food safety. It atomizes and ionizes samples, followed by the detection and quantitative analysis of the resulting ions. This technique provides detailed information on both the types and concentrations of elements. In environmental science, ICP-MS is employed to detect heavy metal concentrations in water, soil, and air, thereby assessing pollution levels and potential ecological risks. In ge......
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• Sedimentation Analysis of Proteins
Sedimentation analysis of proteins refers to the method of determining the sedimentation behavior of proteins in solution using centrifugation techniques. This technique is based on the principle that protein particles separate and can be identified due to changes in relative density under centrifugal force, enabling their characterization. It is a powerful tool with significant applications in structural biology, drug development, and biotechnology. In structural biology, sedimentation analysis of ......
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• MiniTurbo Proximity Labeling
MiniTurbo proximity labeling is a biotinylation-based strategy that utilizes an engineered mutant biotin ligase (TurboID) to rapidly and efficiently tag neighboring proteins. Compared to the conventional BioID technique, MiniTurbo significantly enhances labeling speed and efficiency, making it particularly advantageous for dynamic studies and live-cell experiments. MiniTurbo is a genetically modified biotin ligase fused to a target protein to form a fusion protein. Within the cell, when MiniTurbo appr......
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• Post-Translational Modification Proteomics: Unraveling Disease Mechanisms
Post-translational modification proteomics is the field that investigates various reversible and irreversible modifications occurring on proteins post-synthesis, facilitated by enzymatic activities or chemical reactions. These modifications significantly impact protein structure, stability, activity, subcellular localization, and interaction networks by adding or removing functional groups on amino acid residues. Serving as a regulatory mechanism for cellular processes, post-translational modification......
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• Proteomic Analysis of Post-Translational Modifications: Advancing Drug Development
Proteomic analysis of post-translational modifications is a scientific method used to investigate the chemical modifications proteins undergo after translation and their subsequent effects on protein function. Proteins serve as the primary molecular machinery executing numerous functions within organisms, and post-translational modifications (PTMs) provide a mechanism for the dynamic regulation of these functions. By adding or removing chemical groups such as phosphate, methyl, acetyl, or glycan, PTMs......
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