Resources
Proteomics Databases
Metabolomics Databases
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Stable isotope labeling is a commonly used technique in biomolecular research, enabling precise tracing and quantification of biomolecules. This method relies on isotopes that share the same number of protons but differ in neutron count. While these isotopes exhibit nearly identical chemical properties, their subtle differences in physical properties allow for effective differentiation using mass spectrometry and other analytical techniques. Stable isotope labeling has broad applications, particular......
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MRM assay is a mass spectrometry-based quantitative approach characterized by high sensitivity and specificity. It operates through a tandem scanning mode in triple quadrupole mass spectrometry, where a precursor ion is selected, fragmented via collision-induced dissociation (CID) to produce a specific product ion, and subsequently analyzed through designated ion transitions for highly selective quantification. Compared to traditional full-scan mass spectrometry, MRM assay provides superior selectivit......
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SRM mass spectrometry is a widely utilized analytical technique in proteomics research. Its development dates back to the mid-20th century, and with continuous advancements in mass spectrometry technology, it has been progressively refined. Today, it is an essential tool in many laboratories, serving as a powerful analytical method in scientific research. The applications of SRM mass spectrometry span multiple fields, including biomedical research, drug metabolism studies, environmental monitoring, an......
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• Small Molecule Target Identification
Small molecule target identification is the process of identifying the biological targets of small molecule compounds using experimental techniques or computational approaches, typically involving biomolecules such as proteins, DNA, or RNA. Small molecule drugs play a central role in modern drug development, primarily by binding to specific targets and modulating biological processes to achieve therapeutic effects. However, during drug screening, the precise molecular targets of small molecules are of......
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• Phage Display Protein-Protein Interactions
Phage display protein-protein interactions represent a molecular biology approach that employs phage display technology to investigate interactions between proteins, protein-small molecules, and protein-antibodies. This technique utilizes bacteriophages, primarily M13, T7, or λ phages, as vectors to display exogenous proteins or peptide fragments on the surface of phage coat proteins, enabling specific recognition and selection of target proteins. Phage display has been widely applied in the developme......
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Off-target profiling is a critical methodology for investigating the unintended interactions of drugs, chemical compounds, or biologics with non-target molecules in vivo and in vitro. As a fundamental aspect of drug development and safety evaluation, off-target profiling aims to identify potential nonspecific interactions to mitigate adverse effects, refine drug design, and improve drug safety profiles in clinical applications. While small-molecule drugs, antibody-based therapeutics, and nucleic acid ......
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Membrane targeting sequences are specialized sequences that guide proteins to specific locations on cellular or organelle membranes during their synthesis. These sequences typically contain hydrophobic amino acid stretches that enable interactions with the lipid bilayer or rely on signal peptides, lipid modifications (such as palmitoylation and myristoylation), and specific protein-protein interactions to facilitate stable membrane anchoring. Membrane targeting sequences play a pivotal role in vario......
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Peaks de novo sequencing is a computational method for deriving protein or peptide amino acid sequences directly from mass spectrometry data without relying on known protein sequence databases. In proteomics research, conventional protein identification approaches primarily rely on database-dependent searches, where experimental peptide mass spectra are matched against pre-existing protein databases. However, this approach is inherently limited when analyzing non-model organisms, novel proteins, antib......
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• Free Amino Nitrogen Analysis
Free amino nitrogen analysis is a critical analytical method for quantifying free amino compounds in solution. FAN represents the total concentration of low-molecular-weight nitrogen compounds, including amino acids and short peptides, which serve as key indicators of protein degradation and nitrogen metabolism in biological systems. This analytical technique is extensively utilized in fermentation industries, food science, biomedical research, and environmental monitoring. In the fermentation indus......
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• High-Resolution Mass Spectrometry Services
High-resolution mass spectrometry services provide powerful analytical capabilities for precise molecular mass determination and structural characterization. Compared to low-resolution mass spectrometry, high-resolution mass spectrometry services offer superior mass accuracy, achieving sub-ppm precision, and provide detailed fragmentation patterns, significantly enhancing analytical reliability. The extensive applications of this technology enable researchers to conduct in-depth investigations of biol......
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