Resources

Proteomics Databases



Metabolomics Databases

• • Principles and Applications of Proteomics Data-Independent Acquisition (DIA) Technology

  In the field of biopharmaceuticals, protein quantification is one of the key research areas. Proteomics data-independent acquisition (DIA) technology, as a novel mass spectrometry technique, has the characteristics of high throughput, high sensitivity, and high accuracy, and is gradually becoming an important tool for protein quantification research.

• • How Do Protein Structure Analysis Methods Reveal Three-Dimensional Conformations?

  Methods for protein structure analysis, including X-ray crystallography, nuclear magnetic resonance, and electron microscopy, provide powerful tools for revealing the three-dimensional conformation and function of proteins. These methods have significant application value in drug development and biological research, and will further promote our understanding and application of protein structure and function.

• • Natural Diterpene DA: The "Powerful Tool" from Wikstroemia chamaedaphne for Anti-Renal Fibrosis

  Renal fibrosis is a hallmark pathological feature of chronic kidney disease (CKD), characterized by excessive deposition of extracellular matrix (ECM) in the renal interstitium and sustained fibroblast activation, which critically impairs renal function and reduces patient quality of life. Among the various profibrotic factors, transforming growth factor-β1 (TGF-β1) is widely recognized as the central regulatory factor in renal fibrosis. Consequently, targeting TGF-β1 and its downstream pathways has e......

• • Advances in Single-Cell Transcriptome Analysis

  Single-cell transcriptome analysis is an innovative technique in biological research in recent years, allowing scientists to study gene expression at the single-cell level. This analytical method is crucial for understanding the functions and interactions of individual cells in complex biological systems. In traditional transcriptome analysis, researchers usually use mixtures of a large number of cells, a practice that can obscure differences between different cell types. However, cells in biological ......

• • Advances in Single-Cell Mass Cytometry

  Single-cell mass cytometry integrates the strengths of flow cytometry and mass spectrometry, enabling high-throughput, quantitative analysis of proteins and other biomolecules at the single-cell level. Traditional flow cytometry depends on fluorescent labels to detect protein expression within cells, which limits the number of targets that can be analyzed simultaneously due to the finite types of available fluorescent markers. In contrast, mass cytometry uses metal isotope tags in place of conventiona......

• • Single-Cell DNA Sequencing

  Single-cell DNA sequencing is a powerful technology that allows scientists to extract and analyze genetic information from individual cells with high resolution, identifying genetic differences and variations within cell populations. This method is crucial for understanding cellular evolution during development, the complexity of tissues, and the onset and progression of diseases. Widely applied in cancer research, developmental biology, and personalized medicine, single-cell DNA sequencing reveals th......

• • scRNA Sequencing

  scRNA sequencing is an innovative technology that has emerged in recent years, enabling scientists to comprehensively study gene expression at the single-cell level. This approach is vital for understanding the functions and interactions of individual cells within complex biological systems. Traditional transcriptome analysis often involves large mixtures of cells, which can obscure the differences between various cell types. In contrast, the heterogeneity inherent in biological systems can be better ......

• • Phosphoamino Acid Analysis

  Phosphoamino acid analysis is a technique designed to detect and identify sites of phosphorylation within proteins and assess their modification states. This dynamic and reversible post-translational modification mainly occurs on serine (Ser), threonine (Thr), and tyrosine (Tyr) residues and plays crucial roles in processes such as cell signaling, metabolic regulation, gene expression, and cell cycle control. Phosphorylation is also implicated in diseases like cancer, diabetes, and neurodegenerative d......

• • Protein Purification and Analysis

  Protein purification and analysis is a crucial technology in life sciences, designed to isolate and purify specific proteins from complex biological samples for detailed investigation into their structure, function, and interactions. Proteins are integral to cellular processes, facilitating metabolic reactions, signal transmission, and gene regulation. To elucidate the roles of proteins within organisms, scientists must isolate target proteins from tissues, cells, or other biological sources and utili......

• • Phospho Proteomics Mass Spectrometry

  Phospho proteomics mass spectrometry is an efficient method for investigating the dynamic changes in protein phosphorylation modifications within cells. As a post-translational modification, protein phosphorylation predominantly occurs on serine (Ser), threonine (Thr), and tyrosine (Tyr) residues. It plays a crucial role in regulating protein activity, stability, subcellular localization, and interactions, thereby influencing nearly all biological processes. Abnormal phosphorylation is linked to a ran......