Resources
Proteomics Databases
Metabolomics Databases
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• De Novo Protein Sequencing Applications and Challenges
De novo protein sequencing is a method used to determine the primary structure of proteins directly from experimental data without relying on genomic or protein database references. In proteomics research, de novo protein sequencing plays a crucial role, especially in identifying novel or post-translationally modified proteins from non-model organisms or unknown protein sources, offering indispensable insights. Unlike traditional protein identification methods, which depend on pre-existing protein dat......
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mRNA characterization involves the systematic analysis of the structure, sequence, modifications, and functional properties of messenger RNA (mRNA) using advanced analytical technologies. This process typically encompasses mRNA extraction, quantification, qualitative analysis, and translation efficiency evaluation. As a central intermediary in gene expression, mRNA serves to translate genetic instructions from DNA into proteins, playing a critical role in cellular regulation, organismal development, a......
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Mass spec protein analysis is a powerful method for protein identification, quantification, and structural characterization using mass spectrometry. This technique separates and detects molecules in a sample based on their mass-to-charge ratio (m/z). The typical workflow of mass spec protein analysis begins with sample preprocessing, including protein extraction and enzymatic digestion. The resulting peptides are then separated using techniques such as liquid chromatography (LC) or electrophoresis bef......
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• Mass Spectrometry and Protein Analysis
Mass spectrometry and protein analysis are essential technologies in proteomics, enabling the identification, quantification, and functional characterization of proteins. Mass spectrometry (MS) identifies and quantifies molecules by measuring their mass-to-charge ratio (m/z), while protein analysis investigates protein structures, functions, and interactions. Combined, these technologies offer high-throughput and precise protein analysis, serving as indispensable tools across fields such as basic ......
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Protein structure analysis is a fundamental area of life sciences focused on exploring the three-dimensional conformations of protein molecules. Proteins are essential biomolecules that drive nearly all biological processes, including catalyzing biochemical reactions, transmitting cellular signals, and maintaining structural integrity. The function of a protein is intrinsically linked to its structure, making protein structure analysis indispensable for uncovering functional mechanisms. By examining p......
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iTRAQ proteomics is a mass spectrometry-based high-throughput technique designed for the simultaneous quantification and comparison of protein expression across multiple samples. Since its introduction, iTRAQ (isobaric Tags for Relative and Absolute Quantitation) has become a cornerstone in proteomics, widely applied in biomedical research, drug discovery, and agricultural sciences. The technique labels proteins in biological samples with isotope-tagged reagents, enabling accurate quantification and i......
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Peptide mass spectrometry is a cornerstone technique in modern proteomics research, widely used to identify and quantify peptides and proteins in complex biological samples. This approach enables scientists to comprehensively analyze protein composition and monitor dynamic changes at cellular, tissue, and organismal levels. In fundamental biological research, peptide mass spectrometry provides insights into protein structures, advancing our understanding of intricate biological processes such as gene ......
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Protein analysis services encompass the identification, quantification, and functional characterization of proteins in biological samples. Proteins, as essential executors of life processes, participate in nearly all biological activities, including metabolism, signal transduction, and immune responses. Comprehensive protein analysis provides insights into protein structure, expression levels, post-translational modifications, and protein-protein interactions. In basic research, protein analysis servi......
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Fragmentation peptides are essential intermediates for analyzing the structure and function of complex proteins. Specific enzymes or chemical reagents can cleave protein backbones, generating peptide fragments suitable for subsequent mass spectrometry analysis, protein sequence determination, post-translational modification studies, and biomarker discovery. These shorter peptide chains allow techniques like Edman degradation and mass spectrometry to resolve protein sequences with greater precision. Ad......
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• MALDI Bacterial Identification
MALDI bacterial identification is an advanced mass spectrometry-based technique widely employed for bacterial species, subspecies, and strain identification with exceptional sensitivity and resolution. By integrating matrix-assisted laser desorption/ionization (MALDI) and time-of-flight mass spectrometry (TOF MS), this technology has become a cornerstone in bacterial identification, clinical microbiology, environmental monitoring, and food safety. Its core principle involves irradiating bacterial samp......
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