Resources

Proteomics Databases



Metabolomics Databases

• • Workflow of iTRAQ/TMT and MultiNotch MS Analysis

  Quantitative proteomics is a pivotal field in contemporary biological research, extensively employed in disease mechanism studies, drug target identification, and biomarker discovery. iTRAQ (Isobaric Tags for Relative and Absolute Quantitation) and TMT (Tandem Mass Tag) are widely used techniques that enable relative or absolute quantification of multiple samples through chemical labeling.

• • Advantages and Disadvantages of iTRAQ/TMT-Based Proteomic Quantitation

  In modern life sciences, proteomics technology has become an essential tool for exploring protein expression, modification, and function within biological systems. Quantitative proteomics methods like iTRAQ (Isobaric Tags for Relative and Absolute Quantitation) and TMT (Tandem Mass Tags) use multiplex labeling techniques to perform both relative and absolute quantification of multiple samples simultaneously.

• • Principle of iTRAQ/TMT-Based Quantitative Proteomics

  As proteomics research advances, quantitative proteomics has become essential for deciphering complex biological processes. iTRAQ (Isobaric Tags for Relative and Absolute Quantitation) and TMT (Tandem Mass Tags) are among the most commonly used labeling technologies. These methods allow for relative or absolute quantification comparisons between samples through peptide-level chemical labeling.

• • Capillary Gel Electrophoresis Purity Analysis of Peptide Drugs

  Peptide drugs are a class of drugs primarily composed of peptides and are widely used in the treatment of various diseases, such as cancer, autoimmune diseases, and infectious diseases. Peptide drugs possess high specificity and biological activity, but their efficacy and safety are closely related to their purity. Therefore, efficient, accurate, and sensitive analytical techniques are crucial for assessing the purity of peptide drugs.

• • Elemental Analysis of Antibody Drugs

  Monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, and antibody-drug conjugates are common types of antibody drugs. These drugs are used to treat various diseases by specifically binding to target molecules. Antibody drugs have shown significant efficacy in the treatment of diseases such as cancer, autoimmune diseases, inflammatory diseases, immune modulation, and ophthalmic diseases.

• • Antibody Drug Glycopeptide Analysis

  Antibody drugs are a class of drugs that treat diseases by artificially synthesizing antibodies, which specifically bind to target molecules to achieve therapeutic effects. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, and antibody-drug conjugates. Antibody drugs have shown significant efficacy in treating various diseases such as cancer, autoimmune diseases, inflammatory diseases, immune regulation, and ophthalmic diseases.

• • Combined with UV Spectrum Analysis of Vaccine Carrier Protein

  Conjugate vaccine, also known as covalently linked vaccine, such as pneumococcal vaccine, belongs to a special type of vaccine. The working principle of conjugate vaccine is to combine small molecule antigens (usually polysaccharides) with large molecule carrier proteins, and these carrier proteins usually can induce a strong immune response.

• • Analysis of Glycan Structure of Recombinant Protein Vaccines

  Recombinant protein vaccines are a type of vaccines that do not contain complete pathogens and are prepared from specific protein antigens produced in heterologous expression systems. Recombinant protein vaccines have several advantages, including good safety, strong stability, and relatively low cost, and have been widely favored by researchers in recent years. In recombinant protein vaccines, glycan modification is a key parameter.

• • Analysis of Sialic Acid Content in Recombinant Protein Vaccines

  Recombinant protein vaccines are a class of vaccines that do not contain complete pathogens and are prepared from specific protein antigens produced by heterologous expression systems. Glycosylation is an important post-translational modification of recombinant protein vaccines. Sialic acid (SA) is a derivative of neuraminic acid, an acidic amino sugar with nine carbon atoms and a pyranose structure.

• • Determination of Antibody Drug Extinction Coefficient

  Antibody drugs are a class of drugs that treat diseases through artificially synthesized antibodies, binding specifically to target molecules to achieve therapeutic purposes. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, antibody-drug conjugates, etc.