Resources

Proteomics Databases



Metabolomics Databases

• • Disulfide Bond Localization in Antibody Drugs

  Antibody drugs are a class of protein drugs produced through genetic engineering techniques, including monoclonal antibodies and antibody-drug conjugates. They have high specificity and can precisely target and neutralize disease-related molecules. In these antibody drugs, disulfide bonds are crucial for maintaining the three-dimensional structure and functional stability of the antibodies.

• • Detailed Workflow of Label-Free Proteomics Analysis

  Non-labeled proteomics analysis is an important technique used for studying protein composition and expression. Compared to labeled techniques, non-labeled proteomics analysis has advantages such as simplicity, high throughput, and high sensitivity.

• • NMR Hydrogen Spectrum Analysis of Conjugate Vaccine Carrier Proteins

  Combination vaccines, also known as conjugate vaccines, such as pneumococcal vaccines, belong to a special type of vaccine. The working principle of combination vaccines is to attach small molecule antigens (usually polysaccharides) to large molecule carrier proteins, which can typically stimulate strong immune responses.

• • Full Sequence Analysis of Recombinant Protein Vaccines by Mass Spectrometry

  Recombinant protein vaccines are vaccines prepared using genetic engineering techniques, with the aim of inducing an immune response by expressing and producing specific proteins of the pathogen. These vaccines do not contain the complete active pathogen, but instead select specific proteins or parts of proteins of the pathogen as antigens.

• • Mass Spectrometry Exploring Diverse Sites of Histone Epigenetic Modifications

  Epigenetic modifications are a genetic mechanism that alters gene expression without changing the genetic sequence. It mainly includes DNA methylation of the genome and modifications of histones. Among them, histone modifications are of particular interest in the field of biology and play a crucial role in the study of many major diseases.

• • Neoantigen Screening and Immunotherapy

  Cancer has always been a major threat to human health. However, with the continuous advancement of technology, immunotherapy, as an innovative cancer treatment, has gradually shown great potential. Immunotherapy activates the patient's own immune system to actively attack cancer cells, becoming the beacon of hope in leading the new era of cancer treatment. In personalized immunotherapy, the screening technology for neoantigens plays a crucial role.

• • Mass Cytometry Markers Revealing Cellular Heterogeneity

  Mass cytometry, as an important tool in the field of biopharmaceutical research, has revealed the secrets of cells by accurately measuring protein expression.

• • Mass Cytometry Sample Preparation and Analysis Steps

  In mass spectrometry flow analysis, sample preparation is the first step of the journey and an important part that affects the subsequent analysis. The following steps are essential in the experimental process.

• • How to Optimize Analysis Results of Mass Cytometry Single-Cell Protein Detection?

  Entering the smallest unit of the human body - individual cells, exploring the mysteries of their proteins, mass spectrometry flow cytometry has opened a new window for us to explore the world. This technology can detect thousands of proteins from a single cell, allowing us to decipher the life code of each cell.

• • Disulfide Proteomics Detection and Mass Spectrometry Techniques

  Disulfide bonds play a crucial role in biological systems, as they provide a stable three-dimensional structure to proteins and regulate their functions by connecting two cysteine residues. For example, insulin, a commonly active hormone in the human body, contains disulfide bonds.