Resources
Proteomics Databases
Metabolomics Databases
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Epitope Mapping is a technique used to characterize the interactions between antibodies and antigens and to identify antigenic epitopes. An antigen epitope is a specific region of a protein that can be recognized and bound by the immune system, typically by antibodies or T cell receptors. Epitope mapping is widely applied in biomedical research for vaccine design, diagnostic tool development, and studying the mechanisms of autoimmune diseases. By identifying antigenic epitopes, researchers can gain a......
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ICP-MS analysis (Inductively Coupled Plasma Mass Spectrometry) is a high-sensitivity, high-resolution analytical technique extensively used for elemental analysis, trace element detection, and isotope ratio analysis. This technology combines inductively coupled plasma (ICP) with mass spectrometry (MS), allowing precise detection of elements and their isotopic compositions in samples at extremely low concentrations. As a powerful multi-element analytical tool, ICP-MS has been widely applied across var......
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Ion Chromatography-Mass Spectrometry (IC-MS) integrates ion chromatography (IC) with mass spectrometry (MS) and is widely applied across fields such as chemistry, biology, environmental science, and food safety. Ion chromatography is a technique used to separate ionic compounds, allowing for the efficient detection of both cations and anions in complex samples. Mass spectrometry, meanwhile, analyzes molecular mass and structure by ionizing the sample and measuring its mass-to-charge ratio (m/z), prov......
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DSC and TGA analysis are widely used thermal characterization techniques in fields such as materials science, biology, and chemistry. DSC is primarily employed to assess the thermal properties of materials by recording the heat flow difference between the sample and the reference during temperature changes. This technique is used to investigate thermal behaviors such as phase transitions, glass transitions, crystallization, and melting. TGA, on the other hand, measures the relationship between sample......
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• De Novo Sequencing in Proteomics Research
De novo sequencing, a method widely used in proteomics research, allows for the determination of the amino acid sequence of unknown or partially known proteins. This technique is essential in scientific exploration and biomedical research because it overcomes the limitations of traditional database-dependent methods, enabling the direct derivation of protein sequences from raw mass spectrometry data. De novo sequencing is particularly useful for studying new species, phenotypic variations, or genomic......
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• N-terminal Sequencing in Proteomics
N-terminal sequencing is a critical technique used to analyze the primary structure of proteins, specifically aimed at identifying the amino-terminal (N-terminal) sequence of a protein or peptide chain. As a key approach in proteomics research, this technology is widely employed for protein structure identification, functional studies, sample purity validation, and the investigation of post-translational modifications. By precisely analyzing the amino acid sequence, N-terminal sequencing provides val......
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Edman protein sequencing is a precise method for determining the amino acid sequence of proteins by sequentially identifying the N-terminal residues of a polypeptide chain, thereby establishing the protein's primary structure. Introduced by Pehr Edman in 1950, it has since become a cornerstone in biochemical and molecular biology research. The technique relies on the Edman degradation reaction, where the N-terminal amino acid of the protein or polypeptide reacts with phenylisothiocyanate (PITC) to for......
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• Size-Exclusion Chromatography Protein Purification
Size-exclusion chromatography protein purification is a technique used to separate and purify proteins based on their differences in molecular size. It utilizes porous materials packed within a column, functioning as a sieve that allows components of a mixture to pass through at varying rates, depending on their size, leading to separation. The core principle of this technique is the volume exclusion effect, where larger molecules cannot enter the pores or can only enter larger pores, causing them to ......
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• Size Exclusion Chromatography for Protein Purification
Size exclusion chromatography for protein purification is a widely utilized method in biochemical and proteomics research, allowing the separation of molecules based on differences in size and shape. This technique is essential for ensuring the accuracy and reliability of subsequent analyses, particularly in proteomics. Also known as gel filtration chromatography, the method uses columns packed with porous beads to separate proteins in a mixture. Larger molecules are excluded from the bead pores and e......
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Antibody profiling refers to the detailed study and characterization of the structure, function, and properties of antibodies. As essential components of the immune system, antibodies specifically recognize and bind to antigens, thereby contributing to immune defense. In biomedicine, antibodies are used not only as diagnostic tools but also for the treatment of various diseases, including cancer, autoimmune disorders, and infections. Consequently, antibody profiling plays a pivotal role in drug develo......
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