Resources

Proteomics Databases



Metabolomics Databases

• • Identify Protein from Amino Acid Sequence

  The ability to identify protein from amino acid sequence is a fundamental technique in proteomics research. By analyzing the composition and sequential arrangement of amino acids, this approach provides critical insights into protein structure and function. It plays a pivotal role in protein identification, functional characterization, post-translational modification (PTM) analysis, and the discovery of novel biomarkers. Given that protein function is inherently dictated by its amino acid sequence, th......

• • Identification of New Drug Targets

  The identification of new drug targets is a critical phase in drug discovery, aiming to identify and validate molecular targets that interact with therapeutic compounds and regulate specific physiological or pathological processes. These targets, including proteins, RNA molecules, receptors, and enzymes, play fundamental roles in disease onset and progression. Through systematic target identification, scientists can pinpoint key molecules associated with specific diseases and further investigate their......

• • Hypothetical Protein Analysis

  Hypothetical protein analysis is a key research strategy in proteomics, designed to identify and characterize proteins predicted to exist but not yet confirmed by experimental evidence. These proteins are typically inferred from genome annotations, transcriptomic data, or computational models predicting their potential presence under specific biological conditions. By integrating advanced mass spectrometry techniques with computational bioinformatics, researchers can systematically detect and characte......

• • Global Site-Specific Analysis of Glycoprotein N-Glycan Processing

  The global site-specific analysis of glycoprotein N-glycan processing is a powerful approach for characterizing the precise locations of N-glycan modifications in glycoproteins. This analytical method provides critical insights into glycoprotein biosynthesis, structural integrity, and functional roles at the molecular level. Glycoproteins are vital biomolecules found in cell membranes, extracellular matrices, and circulatory fluids. Their N-glycan modifications influence stability, molecular recogniti......

• • Global Analysis of Protein Structural Changes in Complex Proteomes

  The global analysis of protein structural changes in complex proteomes is a critical yet challenging task for understanding biological processes and disease mechanisms. This approach provides insights into protein function under various physiological and pathological conditions and elucidates their roles in cellular pathways. Investigating protein structural changes enables the identification of disease mechanisms, discovery of potential therapeutic targets, and optimization of drug design. Furthermor......

• • Global Analysis of Protein Localization in Budding Yeast

  The global analysis of protein localization in budding yeast provides a systematic approach to studying the intracellular distribution of proteins. As a model organism, budding yeast offers advantages such as a simple cellular structure and efficient genetic manipulation, making it an ideal system for investigating fundamental biological processes. By conducting global analysis of protein localization in budding yeast, researchers can elucidate protein distribution patterns, subcellular dynamics, and ......

• • Cancer Biomarker Discovery

  Cancer biomarker discovery is a scientific approach that utilizes modern biotechnologies to identify molecular indicators associated with cancer onset, progression, and therapeutic response across multiple biological levels, including genomics, proteomics, and metabolomics. Cancer development is driven by complex genetic and environmental factors, accompanied by molecular alterations in signaling pathways, metabolic regulation, and immune evasion. These changes are often reflected in specific biomarke......

• • Global Analysis of Protein Expression in Yeast

  The global analysis of protein expression in yeast provides a comprehensive investigation of protein expression dynamics within yeast cells. As a widely used model organism, yeast offers advantages such as ease of genetic manipulation and the ability to simulate complex biological processes due to its well-characterized genetic background. Protein expression is fundamental to cellular function, and understanding the global analysis of protein expression in yeast enables researchers to elucidate expres......

• • Antibody Target Identification

  Antibody target identification is the process of determining biomolecules (targets) that an antibody specifically recognizes and binds. This process relies on the principle of antigen-antibody specificity. For instance, immunoprecipitation involves forming antibody-antigen complexes in solution, which are then precipitated using substances that bind to the Fc region of the antibody, allowing target analysis. In affinity chromatography, antibodies are immobilized on a chromatographic medium, and sample......

• • Protein Sequence Analysis Tools

  Protein sequence analysis tools are critical for analyzing amino acid sequences and uncovering the structural, functional, and evolutionary aspects of proteins. Proteins in biological systems perform diverse roles, including catalyzing chemical reactions, transmitting molecular signals, and providing structural support. These tools help researchers perform sequence alignments, structure predictions, function analysis, and other related tasks. This article will introduce several commonly used protein s......