Resources

Proteomics Databases



Metabolomics Databases

• • Mechanism of Quantitative Glycoproteomics

  Glycoproteomics, the study of glycosylation-modified proteins, is of significant value in biomedical research. By analyzing the glycosylation status and changes in the proteome, quantitative glycoproteomics uncovers key regulatory mechanisms in biological processes. With the advancement of mass spectrometry, this field has become an essential tool for investigating protein functions and interactions within complex biological systems.

• • Application of Quantitative Glycoproteomics

  Quantitative glycoproteomics is a powerful technique that elucidates cellular functions through the analysis of protein glycosylation, a critical post-translational modification significantly influencing protein stability, function, and localization. With recent advancements in mass spectrometry, this technique has seen increasing utilization in biomedical research.

• • Principle of Quantitative Glycoproteomics

  Glycoproteomics explores glycosylated proteins and their roles. Glycosylation, a significant post-translational modification, affects protein structure, stability, and function. Quantitative glycoproteomics aims to detect, identify, and quantify glycoprotein glycosylation and expression levels, uncovering dynamic changes during cellular processes.

• • Workflow of Quantitative Glycoproteomics

  Glycoproteomics investigates glycosylation modifications within the proteome and their functional significance. Glycosylation, a widespread post-translational modification of proteins, is pivotal in various biological processes, including cell communication, signal transduction, and immune responses. Quantitative glycoproteomics merges the capabilities of glycoproteomics and quantitative proteomics, enabling comprehensive glycoprotein analysis through mass spectrometry.

• • Mechanism of Quantitative Ubiquitinomics

  In the post-genomic era, the study of protein modifications has become an essential approach for unraveling the mechanisms of various biological processes. Ubiquitination, a crucial post-translational modification, plays a role in regulating numerous cellular processes, including protein degradation, signal transduction, cell cycle control, and stress responses.

• • Application of Quantitative Ubiquitinomics

  Ubiquitinomics is a crucial area of study focused on understanding how proteins are regulated through ubiquitination. This process involves enzymatically attaching ubiquitin molecules to target proteins, affecting their stability, localization, activity, and interactions within the cell.

• • Workflow of Quantitative Ubiquitinomics

  Ubiquitination is a widely conserved post-translational modification in eukaryotes, where small ubiquitin proteins are covalently attached to target proteins, regulating various cellular processes. This modification plays a pivotal role in protein degradation, signal transduction, and DNA repair. With advancements in mass spectrometry (MS) technologies, quantitative ubiquitinomics has emerged as a crucial tool for uncovering the molecular mechanisms and dynamic changes of ubiquitination in cellular systems.

• • Mechanism of Phosphoprotein Enrichment in Phosphoproteomics

  Phosphorylation is a prevalent post-translational modification of proteins, significantly impacting various biological processes such as signal transduction, cell cycle regulation, and metabolism. The study of phosphoproteomics is therefore critical for understanding cellular functions and disease mechanisms.

• • Principle of Quantitative Ubiquitinomics

  Ubiquitination is a crucial post-translational modification, where ubiquitin molecules covalently attach to proteins, regulating their function, localization, and degradation. As mass spectrometry and proteomics technologies advance, quantitative ubiquitomics has emerged as a powerful tool for studying the ubiquitination state of proteins.

• • Application of Quantitative Phosphoproteomics in Cellular Signaling

  Cell signal transduction is a vital process that allows cells to perceive and respond to external stimuli, orchestrating a complex network of biochemical reactions. Phosphorylation, a prevalent post-translational modification, plays a crucial regulatory role in cell signaling.