Resources
Proteomics Databases
Metabolomics Databases
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• Target Identification and Validation in Drug Discovery
Target identification and validation in drug discovery represent critical steps that determine the scientific foundation and strategic direction of pharmaceutical research and development. A “target” refers to a biomolecule—such as a protein, DNA, or RNA—that can bind to a drug and elicit a specific biological effect. In target identification and validation in drug discovery, identification involves the systematic selection of disease-relevant molecular targets using various analytical and computational....
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Prostate cancer proteomics refers to the application of proteomic technologies to systematically investigate alterations in protein expression profiles, regulatory mechanisms, and their associations with clinical features during the initiation and progression of prostate cancer. As a specialized branch within the field of prostate cancer research, prostate cancer proteomics employs large-scale protein quantification, post-translational modification (PTM) profiling, and protein interaction network ........
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• Production and Characterization of Adeno Associated Viral Vectors
The production and characterization of adeno associated viral vectors constitute essential procedures in gene therapy research and development. AAV is a non-pathogenic virus capable of infecting a broad range of mammalian cells. Due to its low immunogenicity and lack of pathogenicity, it has emerged as one of the most promising viral vectors for gene delivery applications. Consequently, ensuring the rigorous production and thorough characterization of AAV vectors is critical for their therapeutic use.
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• High Throughput Chemical Screening
High throughput chemical screening refers to a technology that enables the rapid evaluation of the biological activity or chemical properties of large numbers of compounds within a short period. By leveraging automation, miniaturization, and a variety of technical approaches, this method allows researchers to efficiently identify compounds with potential biological relevance. In drug discovery, HTS is extensively utilized during the initial screening phase for targeted therapeutics. With the support of.....
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X-ray structural analysis (X-ray crystallography) is a classical physical method that exploits the interaction between X-rays and crystalline materials to determine the three-dimensional structures of molecules. It is a cornerstone technique in structural biology, medicinal chemistry, and materials science. By obtaining high-quality crystals of target molecules and irradiating them with X-rays to collect diffraction patterns, researchers can reconstruct electron density maps and accurately derive atomic....
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• Single-Cell Bisulfite Sequencing
Single-cell bisulfite sequencing is a high-throughput sequencing technique designed to assess DNA methylation at single-cell resolution. By integrating bisulfite conversion, single-cell isolation, and high-throughput sequencing, this technology can comprehensively map the genome-wide distribution of 5-methylcytosine (5mC) within individual cells. DNA methylation, a crucial epigenetic regulatory mechanism, plays significant roles in cell fate determination, embryonic development, gene expression regulation..
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Inductively coupled plasma (ICP) is a high-temperature plasma generated by exciting an inert gas (usually argon) under a high-frequency electromagnetic field. It is widely utilized in analytical chemistry for elemental excitation, ionization, and detection. Inductively coupled plasma reaches extremely high temperatures (typically between 6000–10000 K), sufficient to excite or ionize most chemical elements, thereby serving as an efficient excitation source for subsequent spectroscopic or mass spectrometric..
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• Comparison of Peptide Content Determination Methods
Peptide content determination methods play a critical role in fields such as biomedical research, drug development, and protein engineering. Accurate quantification of peptide content facilitates a deeper understanding of their biological functions, supports dose-response evaluations in pharmacology, and ensures quality control throughout production processes. Currently, several primary peptide content determination methods are widely employed, each with distinct principles, advantages, and limitation......
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Scope Cell supernatant proteomics enables the systematic identification of secreted proteins present in the extracellular environment. These proteins often play critical roles in intercellular communication, immune responses, and disease progression. Identifying secreted proteins in the cell supernatant provides valuable insights into extracellular signaling pathways and cellular responses under various physiological and pathological conditions. Quantitative analysis of proteins allows researchers t......
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• How to Analyze Quantitative Proteomics Data
To analyze quantitative proteomics data is to engage in a complex, multi-step process that spans from raw data preprocessing to statistical evaluation and biological interpretation. The following outlines a typical analytical workflow: 1. Data Preprocessing Mass spectrometry data processing begins with software tools such as MaxQuant or Proteome Discoverer, which perform critical steps including peak detection, charge state deconvolution, and mass calibration. Protein identification is conducted b......
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