Resources

Proteomics Databases



Metabolomics Databases

• • Native Mass Spectrometry (MS) Overview

  An overview of native mass spectrometry explaining what native MS measures, how it differs from other MS workflows, typical outputs, and key application areas in protein characterization.

• • PhIP-Seq Study Design for Disease and Control Cohorts

  A practical guide to PhIP-Seq study design for disease and control cohorts, covering inclusion criteria, control matching, sample size, matrix and library choice, batch planning, and analysis alignment.

• • How Many Control Samples Are Needed for PhIP-Seq?

  A practical guide to PhIP-Seq control sample planning, covering control types, minimum numbers by study design, case-control balance, and matrix-matched control requirements.

• • Why PhIP-Seq Candidates Require Orthogonal Validation

  A technical guide explaining why PhIP-Seq candidates require orthogonal validation, covering false-confidence sources, validation pathways, and phased confirmation before autoantigen claims.

• • How to Interpret Enriched Peptides in Autoantibody Studies

  A practical guide to interpreting enriched peptides in autoantibody studies, covering normalization, control contrast, protein mapping, PTM context, and confidence tier assignment.

• • How PhIP-Seq Supports Candidate Autoantigen Discovery

  A technical guide explaining how PhIP-Seq supports candidate autoantigen discovery through library screening, enrichment analysis, protein mapping, and structured validation handoff.

• • PhIP-Seq for Autoantibody Profiling

  A technical overview of PhIP-Seq for autoantibody profiling covering workflow steps, library design, data outputs, applications, and validation planning.

• • Serum vs Plasma vs CSF for Autoantibody Profiling

  A comparison guide to serum, plasma, and CSF for autoantibody profiling covering matrix differences, study goal selection, handling requirements, and workflow implications.

• • How to Prioritize Candidate Autoantigens after PhIP-Seq

  A practical guide to prioritizing candidate autoantigens after PhIP-Seq using filtering, ranking criteria, tiered validation, and orthogonal confirmation workflows.

• • Can PhIP-Seq Detect Conformational or Modified Autoantigens?

  A technical guide explaining whether PhIP-Seq can detect conformational or modified autoantigens, covering library design limits, PTM variant screening, and validation paths for autoimmune serology.