Resources

• • Top Down Proteomics for Protein Analysis

  Top down proteomics is an advanced technology that has been gaining increasing prominence in the field of protein research. Compared to traditional proteomics methods, this approach analyzes intact proteins directly, avoiding the conventional enzymatic digestion step, and thus provides more detailed and comprehensive protein information. It offers distinct advantages, particularly in the study of protein post-translational modifications, protein variants, and structural complexities. This technology i......

• • Protein Analysis Enhancing Scientific Discovery

  Protein analysis plays a pivotal role in elucidating the molecular mechanisms underlying biological processes. By thoroughly examining proteins, researchers gain insights into their structure, function, interactions, and variations across biological contexts. This knowledge is crucial for advancing fundamental research, improving disease diagnostics, and developing novel therapeutics. A major challenge in protein research lies in the efficient separation and extraction of samples. Given the diversity ......

• • Protein Mass Spectrometry for Drug Development

  Protein mass spectrometry is a powerful analytical technique widely used in life sciences, including proteomics research, disease mechanism investigation, and drug development. By precisely measuring the mass and structural characteristics of proteins and their modifications, it provides researchers with essential tools for gaining in-depth insights into biological systems. As a high-sensitivity and high-resolution technique, mass spectrometry is capable of analyzing complex biological samples, reveal......

• • MALDI-TOF Mass Spectrometry in Proteomics

  MALDI-TOF Mass Spectrometry integrates Matrix-Assisted Laser Desorption/Ionization (MALDI) with Time-of-Flight Mass Spectrometry (TOF-MS). Since its introduction by Karas and Hillenkamp in 1988, this technique has become a cornerstone of modern mass spectrometry due to its high resolution, broad mass range, and rapid analytical capabilities. It has been extensively utilized in proteomics, metabolomics, clinical diagnostics, environmental monitoring, and forensic investigations.   The MALDI-TOF Mass Sp......

• • Edman Degradation for Protein Sequence Analysis

  Edman degradation is a classical protein sequencing technique that facilitates the sequential identification of amino acids from the N-terminus of a polypeptide chain. Developed in the 1950s by Swedish chemist Pehr Edman, this method was instrumental in the early stages of molecular biology, establishing a cornerstone for the study of protein structure and function.   Edman degradation relies on the selective chemical reaction of the N-terminus of a polypeptide with phenyl isothiocyanate (PITC), formi......

• • Intact Protein Mass Spectrometry Service in Proteomics Studies

  Intact protein mass spectrometry service is designed to analyze the molecular weight and structural features of non-degraded, full-length proteins. This method plays a crucial role in protein science, particularly in elucidating protein modification states, structural conformations, and molecular interactions. By leveraging this technique, researchers can acquire detailed insights into proteins in their native conformations, providing critical data for advancing the understanding of protein functions.......

• • Advances in Peptide Mapping Analysis for Proteomics

  Peptide mapping analysis is a cornerstone technique in modern proteomics research. Renowned for its high sensitivity and resolution, this method enables comprehensive structural and functional characterization of proteins, supporting sequence confirmation, modification identification, and rigorous quality control. Its applications are increasingly critical in biopharmaceutical development, food science, and fundamental life science research.   The principle of peptide mapping analysis involves enzymat......

• • Accurate Mass Determination in Analytical Applications

  Accurate Mass Determination refers to the measurement of compound molecular mass using high-resolution mass spectrometry, characterized by exceptional precision and reliability. This technique finds extensive applications in fields such as analytical chemistry, pharmaceutical research, environmental science, and the study of macromolecules. By enabling the precise measurement of molecular mass, it facilitates detailed compound identification and structural elucidation.   At its core, Accurate Mass Det......

• • Lipid Content Analysis

  Lipid Content Analysis refers to the process of quantitatively measuring the total lipid content and the levels of various lipid components (such as fats, phospholipids, steroids, etc.) in biological samples. The objective is to accurately determine lipid concentrations using various technical and analytical methods. Common methods for lipid analysis include Soxhlet extraction, gas chromatography, liquid chromatography, and infrared spectroscopy. With ongoing advancements in mass spectrometry, lipid c......

• • Lipid Composition Analysis

  Lipid component analysis refers to the process of qualitatively and quantitatively analyzing lipid molecules in biological samples using scientific techniques. Lipids are essential biomolecules in living organisms, involved in critical physiological processes, including the formation of cell membranes, signal transduction, and energy storage. The core of lipid composition analysis lies in the precise identification of various lipids' types, quantities, and spatial distribution within a given sample. L......