Resources

Proteomics Databases



Metabolomics Databases

• • Mechanism of Protein Sumoylation in Subcellular Localization

  Protein SUMOylation is a critical post-translational modification involving the covalent attachment of SUMO (Small Ubiquitin-like Modifier) to target proteins. Unlike ubiquitination, SUMOylation does not mark proteins for degradation but instead regulates their function by altering their activity, interaction partners, or subcellular localization. SUMOylated proteins are often found enriched in specific subcellular compartments, such as the nucleus, cytoplasm, or cytoskeleton.

• • Application of Protein Sumoylation Identification in Cellular Processes

  Protein SUMOylation refers to the covalent attachment of Small Ubiquitin-like Modifier (SUMO) proteins to target proteins through enzymatic reactions. This post-translational modification plays a pivotal role in regulating protein function, localization, and stability. In recent years, significant attention has been directed towards the role of SUMOylation in various cellular activities, particularly in transcriptional regulation, DNA repair, and cell cycle control.

• • Principle of Protein Sumoylation Identification

  SUMOylation, involving the covalent attachment of Small Ubiquitin-like Modifier (SUMO) to target proteins, is a critical post-translational modification that regulates diverse cellular processes, including nuclear functions, signal transduction, and transcriptional regulation. Accurate detection of SUMOylation sites and the proteins modified by SUMO is essential for understanding the functional roles of this modification.

• • Workflow of Protein Sumoylation Identification

  Protein SUMOylation (Small Ubiquitin-like Modifier, SUMO) is a critical post-translational modification (PTM) that regulates various cellular processes, including protein function, signaling pathways, and gene expression. Understanding the biological significance of SUMOylation requires precise identification and analysis of SUMOylated proteins.

• • Protein Gel Band Identification: From Cross-Linking to Interaction Analysis

  Protein gel strip identification is a commonly used experimental method that helps researchers determine the interaction relationships between proteins.

• • Circular Dichroism Analysis of Peptide Drugs

  Peptide drugs refer to a category of drugs that use peptides for the treatment of diseases. As one of the hotspots in drug development, peptide drugs have significant efficacy, strong specificity, and low toxicity. They are widely used in the treatment of various diseases, including metabolic diseases, neurological diseases, immune diseases, and tumors.

• • Purity Analysis of Antibody Drugs (CE-SDS, SDS-PAGE, SEC, RP, etc.)

  Antibody drugs are a class of drugs that treat diseases through artificially synthesized antibodies. They achieve therapeutic purposes by specifically binding to target molecules. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, antibody-drug conjugates, etc.

• • NMR Analysis of Peptide Drugs

  Polypeptide drugs are large biomolecules formed by the connection of dozens to hundreds of amino acids via peptide bonds. Their biological activity and stability depend on their three-dimensional structure, making the analysis of their structure crucially important.

• • Glycosylation Sites (N-Glycosylation, O-Glycosylation) Detection for Antibody Drugs

  Antibody drugs are a class of drugs that use antibodies to specifically recognize and bind to target molecules. Glycosylation is a critical type of post-translational modification that can affect the stability, biological activity, and immune response of antibody drugs. Glycosylation typically occurs at the N (asparagine) and O (serine or threonine) sites of the antibody.

• • Recombinant Protein Drug Process Impurity Analysis

  Recombinant protein drugs are produced using bioengineering technology, a process that may introduce certain process impurities. These impurities include host cell proteins (HCP), host cell DNA (HCD), protein A, and some substances added during production, such as defoaming agents. These impurities may affect the safety, stability, and biological activity of the drug.