Resources
Proteomics Databases
Metabolomics Databases
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• Differential Expression Proteomics
Differential expression proteomics involves systematically analyzing protein expression levels in various biological conditions-such as health versus disease, treated versus control groups, and different developmental stages-using advanced proteomic technologies. This approach aims to identify proteins with significantly altered expression patterns across these states. At its core, differential expression proteomics utilizes high-resolution mass spectrometry along with sophisticated bioinformatics to ......
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Diabetes proteomics employs high-throughput protein analysis techniques to investigate the protein changes associated with the onset, progression, and complications of diabetes. This approach allows for a comprehensive analysis of the differences in protein expression levels between diabetic patients and healthy individuals, thereby uncovering critical biological processes and molecular mechanisms. With the rapid advancements in mass spectrometry and bioinformatics, diabetes proteomics has become a cr......
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• DIA Proteomics Service: Advancing Disease Research
The DIA proteomics service represents an advanced mode of mass spectrometry data acquisition that has recently garnered significant attention in the field of life sciences. The choice of data acquisition methodology in proteomics research is crucial as it directly impacts the depth and precision of protein identification. Traditional DDA (Data-Dependent Acquisition) methods are limited by their reliance on predefined mass spectrometry screening criteria, which often results in the omission of low-abun......
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• Membrane Protein Mass Spectrometry
Membrane protein mass spectrometry has emerged as a significant technique in recent proteomics research, facilitating the analysis and characterization of proteins within biological membranes. Membrane proteins, which are integral to cell membranes and subcellular membranes, perform crucial roles such as signal transduction, substance transport, and cell recognition. The inherent complexity, structural diversity, and hydrophobic nature of membrane proteins present notable challenges for traditional pr......
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• Membrane Protein Identification
Membrane protein identification involves recognizing and analyzing proteins located on biological membranes using various experimental techniques and bioinformatics methods. These proteins not only provide structural support to cell membranes but also engage in crucial biological processes such as signal transduction, transport of substances, and cell recognition. Understanding membrane proteins is therefore essential for comprehending cellular functions and biological processes. In the medical field,......
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DIGE proteomics is a method for analyzing protein expression changes via differential gel electrophoresis, which highlights proteomic differences across various biological samples. The acronym DIGE refers to Difference Gel Electrophoresis, a technique employing fluorescent labeling of proteins from different samples. This approach allows simultaneous separation and quantitative analysis through fluorescence scanning within the same gel. By facilitating the concurrent analysis of multiple samples, DIGE......
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Co-IP results refer to the protein interaction data obtained from Co-immunoprecipitation (Co-IP) experiments, which include the identification of the target protein and its binding partners. Co-immunoprecipitation is a technique based on the specific binding between antigens and antibodies, used to study the composition and interactions of protein complexes. This technique enriches the target protein and its interaction partners under near-physiological conditions, and subsequent analysis using Wester......
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Protein network mapping involves the systematic investigation of protein interactions to create functional association networks that uncover the intricate mechanisms of intracellular signal transduction, metabolic regulation, and disease progression. In cellular biology, functions are typically executed by a coordinated effort of multiple proteins rather than by individual proteins in isolation. Therefore, exploring protein interactions and their network relationships is crucial for understanding the ......
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Deep proteomics is an advanced technology in proteomics, focusing on the comprehensive analysis of protein diversity, expression levels, post-translational modifications, and interactions within biological samples. Unlike traditional proteomic methods, deep proteomics employs highly sensitive and high-resolution mass spectrometry, alongside optimized techniques for sample preparation, separation, and data analysis. This approach allows for a more complete and precise characterization of the proteome i......
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• Biomarker Discovery Proteomics
Biomarker discovery proteomics is a scientific discipline that employs proteomic techniques to screen, identify, and validate biomarkers, aiming to uncover key protein molecules involved in disease states, drug responses, or physiological processes. Biomarkers refer to biological molecules that can be objectively measured to assess normal biological processes, pathological states, or responses to therapeutic interventions. Proteins, being the primary functional molecules in living organisms, provide i......
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