Resources

Proteomics Databases



Metabolomics Databases

• • Alkylation Proteomics

  Alkylation proteomics is a specialized area of proteomics that focuses on the study of protein alkylation modifications. This field mainly utilizes high-resolution mass spectrometry to identify alkylation modification sites, patterns, and their biological functions. Alkylation modifications are covalent alterations where alkyl groups, such as methyl or ethyl, are introduced into the side chains or main chains of amino acids within proteins. This can impact protein structure, stability, interactions, a......

• • Absolute Protein Quantification Mass Spectrometry

  Absolute protein quantification mass spectrometry is a powerful technique for the precise quantitative analysis of proteins in complex biological samples. It finds extensive application in biomedical research, drug development, and clinical diagnostics. By leveraging this technology, researchers can accurately determine the absolute concentration of proteins within a sample, providing critical data for early disease diagnosis, drug efficacy evaluation, and biomarker discovery. This method not only aid......

• • Protein-Protein Interaction Services

  Protein-Protein Interactions play a critical role in regulating physiological activities, biochemical reactions, and signal transduction processes within organisms. Protein-Protein Interaction Services enable researchers to identify, analyze, and comprehend the complexity of these interactions. By utilizing these services, scientists can predict potential biological roles, elucidate underlying mechanisms, and identify novel therapeutic targets. As such, Protein-Protein Interaction Services are widely ......

• • Comprehensive Characterization of Protein-Protein Interactions Perturbed by Disease Mutations

  The comprehensive characterization of protein-protein interactions perturbed by disease mutations is crucial for understanding disease pathogenesis, identifying potential therapeutic targets, and developing new treatments. Protein-protein interactions are fundamental to the biological functions in organisms, with nearly all life processes depending on the complex and precise interactions between proteins. However, mutations in genes, especially those associated with diseases, often disrupt these inter......

• • Biosimilar Antibody Sequencing

  Biosimilar antibody sequencing refers to the detailed analysis of the DNA and protein sequences of biosimilar antibodies. As the biopharmaceutical field continues to grow, antibody biologics are becoming increasingly important in treating various diseases. However, due to the high costs of development, complex clinical trials, and lengthy timeframes, the emergence of biosimilars provides a promising solution to reduce treatment costs and improve drug accessibility. The aim of biosimilar antibody seque......

• • Autoantibody Biomarker Discovery

  Autoantibody biomarker discovery is a multifaceted process that integrates various technical approaches, alongside stringent validation and mechanistic studies, to ensure the clinical relevance of the identified biomarkers. Detecting specific autoantibodies in the human body offers a valuable tool for diagnosing numerous diseases. Autoantibodies are produced by the immune system against the body’s own tissues during immune dysfunction. These antibodies serve as hallmark markers of autoimmune diseases,......

• • Whole Proteome Analysis

  Whole proteome analysis is a proteomics research approach based on mass spectrometry technology, designed to systematically examine the types, quantities, functions, and interactions of all proteins within biological organisms or cells. Unlike traditional targeted protein analysis, whole proteome analysis offers a comprehensive tool for understanding the functions and mechanisms of biological systems by identifying and quantifying all proteins in complex biological samples. This technique has broad ap......

• • Whole Protein Mass Spectrometry

  Whole protein mass spectrometry is a mass spectrometry-based high-throughput proteomics technique designed to comprehensively analyze the protein composition, expression levels, post-translational modifications, and interactions within biological samples. In comparison with traditional protein detection techniques such as Western Blot or ELISA, whole protein mass spectrometry offers significant advantages, including unbiased, highly sensitive, and high-resolution analysis. It enables the identificatio......

• • 4 Steps of Edman Degradation

  Edman degradation is a widely used method for determining the amino acid sequence of peptides and proteins. The 4 steps of Edman degradation involve: initial reaction, cyclization, cleavage, and repetitive cycles. In the first step, the N-terminal amino acid reacts with phenylisothiocyanate (PITC), forming a phenylthiocarbamyl derivative. During cyclization, under acidic conditions, a cyclic derivative (thiazolinone) is formed. In the cleavage step, the cyclic product is converted to phenylthiohydanto......

• • Total Amino Acid Analysis

  Total amino acid analysis involves the comprehensive quantitative and qualitative assessment of all amino acids present in biological or chemical samples. By comparing retention times of sample amino acids to those of standards, the identity of amino acids can be established. A match in retention times indicates the presence of a specific amino acid in the sample. Quantification is achieved through standard curve methodology, where standard curves for each amino acid are constructed. By measuring the ......