Resources

Proteomics Databases



Metabolomics Databases

• • Protein and Peptide Mass Spectrometry in Drug Discovery

  Protein and peptide mass spectrometry in drug discovery is a highly sensitive and precise technique widely employed throughout various stages of drug development. By measuring the mass-to-charge ratio (m/z), mass spectrometry reveals the chemical composition, structural features, and post-translational modifications of proteins and peptides. This technique is not only applied in drug screening and target validation but is also extensively used in studies of drug metabolism, toxicity, and clinical effi......

• • Protein Analysis by Shotgun Bottom-Up Proteomics: Advances and Applications

  Protein analysis by Shotgun Bottom-Up proteomics is one of the two widely employed techniques in modern proteomics. It utilizes distinct approaches to comprehensively analyze proteins, enabling researchers to extract valuable insights from complex biological samples. The adoption of these methods has significantly advanced the field of proteomics, facilitating an in-depth biological understanding in diverse areas such as disease investigation, drug development, and nutrition. The Shotgun strategy ......

• • Ligand Identification

  Ligand identification is the process by which molecules that interact with biomacromolecules, such as proteins and nucleic acids, are recognized and confirmed using various methods and techniques. These ligands may include small molecule drugs, natural products, hormones, antibodies, or other chemical entities. By binding to biomacromolecules, ligands regulate their functions and play crucial roles in biological processes like cell signaling, metabolic pathways, and immune responses. This ligand-recep......

• • ICP-MS Quantitative Analysis

  ICP-MS quantitative analysis is widely used in fields such as environmental science, geology, biomedicine, and food safety. It atomizes and ionizes samples, followed by the detection and quantitative analysis of the resulting ions. This technique provides detailed information on both the types and concentrations of elements. In environmental science, ICP-MS is employed to detect heavy metal concentrations in water, soil, and air, thereby assessing pollution levels and potential ecological risks. In ge......

• • Sedimentation Analysis of Proteins

  Sedimentation analysis of proteins refers to the method of determining the sedimentation behavior of proteins in solution using centrifugation techniques. This technique is based on the principle that protein particles separate and can be identified due to changes in relative density under centrifugal force, enabling their characterization. It is a powerful tool with significant applications in structural biology, drug development, and biotechnology.   In structural biology, sedimentation analysis of ......

• • MiniTurbo Proximity Labeling

  MiniTurbo proximity labeling is a biotinylation-based strategy that utilizes an engineered mutant biotin ligase (TurboID) to rapidly and efficiently tag neighboring proteins. Compared to the conventional BioID technique, MiniTurbo significantly enhances labeling speed and efficiency, making it particularly advantageous for dynamic studies and live-cell experiments. MiniTurbo is a genetically modified biotin ligase fused to a target protein to form a fusion protein. Within the cell, when MiniTurbo appr......

• • Proteomic Analysis of Post-Translational Modifications: Advancing Drug Development

  Proteomic analysis of post-translational modifications is a scientific method used to investigate the chemical modifications proteins undergo after translation and their subsequent effects on protein function. Proteins serve as the primary molecular machinery executing numerous functions within organisms, and post-translational modifications (PTMs) provide a mechanism for the dynamic regulation of these functions. By adding or removing chemical groups such as phosphate, methyl, acetyl, or glycan, PTMs......

• • Post-Translational Modification Proteomics: Unraveling Disease Mechanisms

  Post-translational modification proteomics is the field that investigates various reversible and irreversible modifications occurring on proteins post-synthesis, facilitated by enzymatic activities or chemical reactions. These modifications significantly impact protein structure, stability, activity, subcellular localization, and interaction networks by adding or removing functional groups on amino acid residues. Serving as a regulatory mechanism for cellular processes, post-translational modification......

• • Plasma Proteome Profiling

  Plasma proteome profiling involves the comprehensive study of plasma proteins, including their types, quantities, post-translational modifications, and dynamic alterations, utilizing high-throughput mass spectrometry and advanced bioinformatics. Plasma, as a bodily fluid, holds proteins from all body organs and tissues, making it an effective medium for reflecting physiological states and disease progression. Consequently, this analysis finds extensive applications in early diagnosis, exploration of p......

• • Plant Proteomics: Unlocking Molecular Mechanisms

  Plant proteomics is the scientific study of all proteins within plant organisms, focusing on their composition, structure, function, and changes under varying physiological and environmental conditions. The rapid advancements in genomics and mass spectrometry technologies have made plant proteomics a powerful tool for delving into the molecular mechanisms underlying plant growth, development, metabolism, and environmental stress responses. The primary objective of this proteomic technology is to ident......