Resources

Proteomics Databases



Metabolomics Databases

• • Revealing Protein-Ligand Interactions Using Chemical Proteomics

  Protein-ligand interactions are essential for nearly all intracellular biological processes. Ligands involved in these interactions can include small-molecule drugs, metabolites, lipids, and even metal ions. Gaining a detailed understanding of these interactions is crucial for elucidating signaling pathways, regulatory networks, and disease mechanisms. Furthermore, such insights play a vital role in drug discovery, target validation, and mechanistic studies. However, due to their highly dynamic nature......

• • How Does Bioinformatics Enhance Protein Sequencing

  With the exponential growth in data volume, traditional experimental methods for protein sequencing are increasingly inadequate to meet the demands of proteomics for high-throughput, precision, and multi-dimensional data analysis. From sequence identification to structural modeling, and from modification site prediction to functional annotation, bioinformatics is fundamentally transforming the workflow and efficiency of protein sequencing. This paper explores how bioinformatics empowers protein sequencing..

• • Mass Spectrometry-Based Protein Sequencing: Principles and Advantages

  With the advancement of precision medicine, biopharmaceutical development, and fundamental scientific research, acquiring high-quality protein sequence information has become essential in the field of life sciences. As the primary functional entities in biological systems, proteins rely on their primary structure—the amino acid sequence—for proper function. This sequence is foundational for understanding protein functionality, elucidating disease mechanisms, and designing targeted therapeutics. Driven by...

• • Peptide Sequencing Techniques: Challenges and Breakthroughs

  What Is Peptide Sequencing? Why is it so Critical? Peptides are short chains composed of 2–50 amino acid residues, which can be degradation products of proteins, functional signaling molecules, bioactive drugs, or even vaccine antigen epitopes or TCR peptide segments. The primary objectives of peptide sequencing include: Confirming the amino acid sequence of antibody CDR regions. Identifying endogenous bioactive peptides (such as hormones and cytokines). Verifying the structure of degradation products......

• • How to Perform High-Precision Antibody Sequencing?

  Antibody sequencing has garnered significant attention in recent years as a crucial tool for the development of antibody drugs and the characterization of antibodies. In particular, scenarios such as CDMO contract manufacturing, antibody humanization, patent portfolio design, and consistency analysis have imposed increasingly stringent requirements on the accuracy, completeness, and functional site identification of antibody sequences. How can high-precision antibody sequencing be achieved? What key steps..

• • Protein Mass Spectrometry Analysis: How to Improve Accuracy and Sensitivity

  Protein mass spectrometry (MS) analysis, as a core technology in modern proteomics, has been widely employed in studies of disease mechanisms, drug target identification, and biomarker discovery. However, enhancing the accuracy and sensitivity of protein mass spectrometry analysis remains a critical challenge in practical applications. Sample Preparation: The Foundation for High-Quality Data The quality of sample preparation plays a decisive role in determining the performance of subsequent mass .......

• • Comprehensive Analysis of Protein Sequence: Methods and Challenges

  The amino acid sequence of a protein fundamentally underlies its structure and function. Comprehensive protein sequence analysis not only reveals the molecular identity of a protein but also provides critical insights into its functional mechanisms, disease-associated variations, and target drug design. In the current era of rapid advancement in omics research, achieving efficient and accurate determination of protein primary structures has become an indispensable and pivotal technical aspect of .......

• • History and Trends in Protein Sequencing

  The history of Protein Sequencing technology has marked the transition of modern life sciences from chemical reactions to system-level omics. From the pioneering Edman degradation method to today’s proteomics platforms centered around high-resolution mass spectrometry, the technological evolution of Protein Sequencing has continually expanded the depth, throughput, and functional analytical capacity of detection, laying a robust foundation for decoding the blueprint of life. This paper reviews the pivotal..

• • Overview of Protein Sequencing: Advantages and Limitations

  Proteins act as the primary executors of biological functions, with their structure and functionality intricately dependent on the precise arrangement of amino acid sequences. Protein sequencing technology serves as a crucial bridge linking genomics and phenotypic research, advancing our comprehension of biological systems. Utilizing high-resolution mass spectrometry, protein sequencing enables comprehensive qualitative and quantitative characterization of proteins by analyzing peptide fragmentation .......

• • Recommendations for 5 Commonly Used Protein Sequence Alignment Tools

  Introduction: Why Is Protein Sequence Alignment so Important? The function of a protein is often reflected in its amino acid sequence. Conserved regions, active sites, and modification sites within the sequence serve as critical indicators for predicting protein function. By aligning a target sequence with known protein sequences in public databases, researchers can: annotate the functions of uncharacterized proteins; identify homologous proteins and evolutionary relationships; detect domains, binding......