Resources

Proteomics Databases



Metabolomics Databases

• • PROTAC Drug Discovery

  PROTAC drug discovery represents an innovative approach to therapeutic development that leverages the technology of proteolysis-targeting chimeras (PROTACs) to achieve targeted protein degradation. A PROTAC molecule typically consists of two functional ligands: one specifically binds to the target protein, while the other recruits an E3 ubiquitin ligase. These ligands are connected via an appropriate linker, forming a bifunctional molecule that facilitates ubiquitination and subsequent proteasomal deg......

• • Host Cell DNA Analysis

  Host cell DNA analysis refers to the detection and evaluation of DNA present in host cells using a variety of analytical techniques. This process is of critical importance in the biopharmaceutical industry, as host cells typically refer to cell lines used in the production of biologics, such as CHO cells and E. coli. During the manufacturing process, residual DNA fragments from these cell lines may remain in the final product. If not effectively detected and removed, these contaminants can compromise ......

• • De Novo Transcriptome Analysis

  De novo transcriptome analysis is a powerful approach for comprehensively profiling the transcriptome of organisms, particularly those lacking fully sequenced or annotated genomes. This technique enables researchers to capture the full spectrum of RNA molecules expressed under specific conditions, facilitating the elucidation of complex gene expression patterns and regulatory networks.   One of the key applications of de novo transcriptome analysis lies in gene discovery and functional annotation in n......

• • 10x BCR Sequencing

  10x BCR sequencing is an advanced genomic technology specifically designed to investigate the complexity and dynamic changes of B cell receptors (BCRs). BCRs are essential components of the human immune system, responsible for recognizing and binding to foreign antigens, thereby initiating immune responses. By leveraging 10x BCR sequencing, researchers can gain in-depth insights into the processes of BCR gene recombination and somatic hypermutation, revealing how individual immune systems adapt to and......

• • 10x TCR Sequencing

  10x TCR sequencing is a cutting-edge technology designed to comprehensively profile the diversity and complexity of T cell receptors (TCRs). TCRs are protein complexes expressed on the surface of T cells, responsible for recognizing foreign antigens and initiating immune responses. Each T cell harbors a unique TCR sequence, and this diversity is a critical feature enabling the immune system to effectively detect and eliminate a wide array of pathogens. 10x TCR sequencing plays an essential role in bot......

• • Single Cell Transcriptome Sequencing in Cancer and Neuroscience Research

  Single cell transcriptome sequencing is a powerful technique used to analyze gene expression profiles at the resolution of individual cells. It plays a vital role in modern biological research by revealing the molecular characteristics of cells under different physiological conditions. Its applications are particularly prominent in cancer research, where tumors are often composed of heterogeneous cell populations exhibiting distinct gene expression patterns and functional profiles. Single cell transcr......

• • Single Cell Targeted Sequencing

  Single cell targeted sequencing (scTS) is designed to enable high-resolution analysis of specific genomic regions within individual cells. This approach offers distinct advantages for extracting detailed genetic information from complex biological samples. Traditional genomic sequencing methods typically require large numbers of cells, yielding population-averaged results that obscure cell-to-cell variability. In contrast, single cell targeted sequencing provides genome-level insights at single-cell r......

• • Single Cell RNA Sequencing Technology

  Single cell RNA sequencing technology (scRNA-seq) has emerged as a pivotal tool in biomedical research, with wide-ranging applications in oncology, neuroscience, immunology, and developmental biology. In cancer research, scRNA-seq enables the identification of tumor heterogeneity, uncovering the molecular signatures of distinct cancer subtypes and informing the development of personalized treatment strategies. In neuroscience, the technology allows for the exploration of neuronal diversity and charact......

• • Single Cell RNA and DNA Sequencing

  Single cell RNA and DNA sequencing enables comprehensive profiling of the genome and transcriptome at the resolution of individual cells. Single cell DNA sequencing is primarily employed to uncover genomic alterations within individual cells, including copy number variations, point mutations, insertions and deletions, as well as complex structural rearrangements. This is particularly critical for understanding the pathogenesis of diseases such as cancer, where tumor cells often exhibit high degrees of......

• • Single Cell Nucleic Acid Sequencing

  Single cell nucleic acid sequencing enables comprehensive genomic and transcriptomic analyses at the resolution of individual cells. This powerful technique allows scientists to uncover gene expression profiles across diverse cell types, providing insights into cellular function, state, and identity—even permitting the identification of rare cell populations. Its applications are broad, with one of the most impactful areas being cancer research. Tumors often exhibit significant cellular heterogeneity,......