Resources

Proteomics Databases



Metabolomics Databases

• • Mechanism of Proximity Extension Assay in Olink Analysis

  Olink analysis is a highly sensitive protein detection platform with broad applications in biomarker discovery, clinical research, and drug development. One of its core technologies is the Proximity Extension Assay (PEA), which utilizes antibody recognition combined with DNA extension to detect hundreds of proteins in complex biological samples simultaneously.

• • Application of Olink Proteomics in Biomarker Discovery

  Olink proteomics technology, known for its highly sensitive and precise protein quantification capabilities, has become a pivotal tool in the field of biomarker discovery. By combining multiplex immunoassays with high-throughput liquid chip technology, Olink allows the quantification of a large number of proteins in a single experiment. This not only shortens research timelines but also improves the accuracy and reproducibility of results.

• • Advantages and Disadvantages of Olink Analysis

  Olink analysis is a cutting-edge proteomics tool based on Proximity Extension Assay (PEA) technology, increasingly applied in biomedical research. Its combination of high sensitivity, specificity, and high-throughput detection allows the measurement of hundreds of proteins from minimal sample volumes. Below, we explore in detail the advantages and disadvantages of this technology.

• • Workflow of Olink Proteomics

  Olink proteomics is a high-throughput technique leveraging protein-specific antibodies, widely used in life sciences for the simultaneous detection and quantification of numerous proteins. This method uses a unique immuno-amplification mechanism, enabling the analysis of hundreds to thousands of target proteins in a single assay, which is especially useful in clinical and basic research.

• • Principle of Olink Proteomics

  Olink proteomics is an advanced technology based on Proximity Extension Assay (PEA), allowing the simultaneous measurement of multiple target proteins with exceptional sensitivity and specificity. The core concept of PEA involves the use of antibodies that specifically bind to target proteins, coupled with precise protein quantification using DNA sequence tags attached to the antibodies.

• • Mechanism of Chemical Proteomics Analysis

  Chemical proteomics is a research approach that combines chemical tools with mass spectrometry to study protein function, interactions, and modification states. The central mechanism involves using chemical probes, reactive compounds, or labeling molecules to identify proteins or their modification sites, followed by qualitative and quantitative analysis using mass spectrometry.

• • Application of Chemical Proteomics Analysis

  Chemical proteomics, a technique that utilizes chemical probes and targeted reactions to detect and functionally analyze proteome components, has found broad applications in the biomedical field. With advancements in analytical techniques, chemical proteomics has become a powerful tool for biological research and drug development. Its application spans from target identification to biomarker discovery, advancing research in precision medicine and drug development.

• • Principle of Chemical Proteomics Analysis

  Chemical proteomics is an emerging field that leverages the interaction between chemical probes and proteins to study protein function, structure, and activity within the cellular environment. By integrating chemical synthesis with proteomics techniques, it allows the identification, quantification, and functional analysis of proteins through specific chemical modifications or labeling.

• • Workflow of Chemical Proteomics Analysis

  Chemical proteomics is a technique that utilizes chemical methods to label, capture, or modify proteins in order to study their structure and function. This analytical technology has broad applications in drug discovery, biomarker identification, and protein function research. The workflow of chemical proteomics analysis typically involves several key steps, each of which is crucial for the success of the experiment. Below is a detailed description of the workflow of chemical proteomics analysis.

• • Mechanism of AQUA in Protein Detection

  Absolute Quantification of proteins (AQUA) is a key technology in proteomics, utilizing stable isotope-labeled peptides for precise protein quantification. Combined with mass spectrometry (MS), AQUA enables the absolute quantification of target proteins, providing crucial insights into biomarker discovery, drug target validation, and functional analysis of proteins.