Resources
Proteomics Databases
Metabolomics Databases
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• Metabolite Set Enrichment Analysis
Metabolite set enrichment analysis is a powerful technique aimed at elucidating the metabolic states of organisms by identifying and assessing changes in metabolites present in biological samples. Metabolites, which are the intermediate or final products of chemical reactions within organisms, undergo concentration changes that reflect the metabolic activities of cells, tissues, and entire organisms under varying physiological and pathological conditions. By systematically examining these metabolite c......
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• X-Ray Crystallography in Protein Analysis
X-ray crystallography in protein analysis is a classical structural biology technique based on the principle of X-ray diffraction, widely used to determine the three-dimensional structures of proteins. Since its development in the mid-20th century, this technique has profoundly advanced our understanding of the conformational characteristics and functional mechanisms of biomolecules. It has also served as a cornerstone in driving breakthroughs in modern biochemistry, molecular biology, and rational dr......
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10x Genomics DNA sequencing, as a leading high-throughput sequencing technology, enables comprehensive and detailed genomic analysis by integrating droplet microfluidics with advanced single-cell capture methods. This technique is widely applicable in various fields, including cancer genomics, genetic disease analysis, and evolutionary biology. In cancer research, 10x Genomics DNA sequencing facilitates single-cell analysis of tumor samples, allowing researchers to identify and monitor genetic heterog......
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10x genome sequencing is an advanced single-cell sequencing technology designed to reveal the genetic diversity and complexity of individual cells by analyzing their genomic information. This technology demonstrates broad application potential across various biomedical fields, including cancer research, developmental biology, immunology, and neuroscience. In cancer research, 10x genome sequencing enables scientists to identify clonal heterogeneity within tumors. By sequencing the genomes of individu......
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10x V (D) J sequencing represents a cutting-edge approach for dissecting the complexity of the immune system at the single-cell level. This technique enables detailed analysis of B and T cell receptor rearrangements, showing substantial potential in vaccine development, immunotherapy design, and in vitro diagnostics. By evaluating immune responses to various pathogens, researchers can identify effective antigen targets, facilitating the advancement of novel vaccines. Moreover, tracking immune cell dyn......
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10x Chromium sequencing technology is a cutting-edge tool for analyzing the complexity of genomes, transcriptomes, and epigenomes at the single-cell level. By precisely barcoding RNA and DNA molecules within individual cells, this technology enables researchers to delve deeply into cellular heterogeneity and dynamic changes. The applications of 10x Chromium sequencing are extensive, spanning oncology, immunology, neuroscience, and developmental biology. In oncology, this technology offers new insights......
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• Single-Cell DNA Methylation Sequencing
Single-cell DNA methylation sequencing is instrumental in analyzing DNA methylation patterns in individual cells. DNA methylation, a pivotal epigenetic modification, involves the addition of methyl groups primarily at cytosine bases within the DNA sequence. This modification impacts gene expression without altering the DNA sequence, playing vital roles in gene regulation, cellular development, and differentiation. Abnormal methylation patterns are closely linked to various diseases, particularly cance......
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• Single-Cell Exome Sequencing
Single-cell exome sequencing technology is designed to investigate gene expression differences at the single-cell level. The exome encompasses the genome's protein-coding regions, which are vital for cellular functions. Through single-cell exome sequencing, researchers can precisely examine the gene-level distinctions among various cell types, shedding light on the differential functional characteristics inherent to each cell. In cancer research, this technology can pinpoint rare but lethal oncogenic ......
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• Mouse Liver Single Cell RNA Seq
Mouse liver single cell RNA sequencing technology specializes in the analysis of RNA expression at the single-cell level within the mouse liver. This method reveals the gene expression profiles and functional states of various cell types. By resolving the heterogeneity inherent in biological samples, it serves as a powerful tool for investigating the biological characteristics of the liver, mechanisms of diseases, and drug effects. The liver, as a complex organ, performs essential physiological functi......
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• Long-Read Single-Cell Sequencing
Long-read single-cell sequencing, which integrates long-read sequencing with single-cell analysis, has emerged as a powerful tool for dissecting complex biological questions. This technique has demonstrated significant potential across various research domains. In cancer research, long-read single-cell sequencing provides precise identification and localization of structural variations and point mutations within the genome. By delivering high-resolution genome maps, it facilitates a deeper understandi......
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