Resources

Proteomics Databases



Metabolomics Databases

• • Protein Phosphorylation Modification 4D-DIA Label-Free Quantification Technique

  Protein phosphorylation is a pivotal form of post-translational modification, essential for cellular signaling, cell cycle regulation, growth, differentiation, and apoptosis. Investigating protein phosphorylation is thus of immense scientific and clinical importance. Recently, the advent of 4D-DIA label-free quantification technology has introduced a novel approach to proteomics analysis. This method integrates ion mobility chromatography (IMC), tandem mass spectrometry (MS/MS), and data-independent........

• • Protein Chemical Sequencing Method

  Protein chemical sequencing is a pivotal biochemical technique used for elucidating the amino acid sequences of proteins. This method is essential for comprehending the architecture and functionality of proteins and is immensely valuable in drug discovery and disease diagnostics. Below, we present a detailed overview of the fundamental steps and applications of protein chemical sequencing.

• • The Importance of Glycomic Analysis

  Glycomics is a technique for investigating sugar metabolism in organisms by measuring and analyzing changes in glycan composition and concentration. This approach has extensive applications in biomedical research, food science, and biotechnology. Providing Fundamental Insights for Biochemical Research: Glycomics serves as a crucial tool in biochemical studies. Sugars are not only a major source of energy but also essential mediators in numerous biological processes. A comprehensive understanding of glycan..

• • Translate the Amino Acid Sequence of the Peptide by Mass Spectrometry Analysis

  Liquid Chromatography-Mass Spectrometry (LC-MS) is a widely used analytical technique for determining the amino acid sequences of peptides. By integrating liquid chromatography (LC) with mass spectrometry (MS), LC-MS enables comprehensive structural characterization of peptides with high sensitivity, accuracy, and resolution. Fundamental Principles of Liquid Chromatography-Mass Spectrometry: The principle of LC-MS involves two key stages: chromatographic separation followed by mass spectrometric detection.

• • Amino Acid Sequence Feature Analysis

  Amino acid sequences play a fundamental role in biological research, as they serve as the primary structural units of proteins. In bioinformatics—a field that integrates computational approaches with biological data—the analysis of amino acid sequence characteristics is a crucial task. Amino Acid Sequences: Amino acid sequences are synthesized during the translation of nucleic acids into proteins within animal cells. Each amino acid sequence encodes specific biological functions and holds significant.......

• • Analysis of Protein Chemical Modification

  Protein chemical modifications are essential physiological processes that significantly influence protein stability, localization, activity, and interactions with other molecules in living organisms. Analyzing and understanding these modifications can provide valuable insights into the complex biological activities occurring within organisms. Types of Protein Chemical Modifications: Protein chemical modifications include several types, such as phosphorylation, acetylation, methylation, ubiquitination, and..

• • The Latest Histone Modification Research

  Histone modification is a complex biochemical process that influences chromatin structure and regulates gene expression. This involves the dynamic wrapping and unwrapping of DNA and the subsequent activation or repression of genes, all of which rely on intricate biochemical reactions within the cell. Researchers have identified several types of histone modifications, including acetylation, methylation, phosphorylation, ubiquitination, and arginine methylation, each playing critical roles in various.........

• • Protein Identification: Experimental Strategies, Technological Advances, and Applications

  Protein identification is fundamental to proteomics, aiming to determine the presence, sequence, and functional role of specific proteins in biological samples. Over the past decades, advancements in analytical techniques have transformed protein identification from traditional biochemical methods to high-throughput mass spectrometry-based approaches, significantly improving accuracy, sensitivity, and throughput. Whether analyzing a single protein or profiling complex proteomes, researchers continuous......

• • Mass Spectrometry in Protein Identification: Methods, Advantages, and Challenges

  Protein identification aims to elucidate the functions and roles of proteins within biological systems by analyzing their molecular structure, sequence, and post-translational modifications. Mass spectrometry has emerged as a gold standard in this field, enabling researchers to precisely determine protein molecular weight, sequence, and post-translational modifications, irrespective of protein complexity. Consequently, mass spectrometry plays a pivotal role in proteomics, disease research, and novel d......

• • Electrophoretic Detection of Protein Phosphorylation

  Phosphorylation is a critical post-translational modification in biological systems. The analysis of protein phosphorylation via electrophoresis provides valuable insights into its biological properties. Phosphorylation is one of the most prevalent post-translational modifications in cells, predominantly occurring on serine, threonine, and tyrosine residues. The attachment of phosphate groups to specific amino acid residues can significantly alter protein structure and function.