Resources
Proteomics Databases
Metabolomics Databases
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Shotgun proteomic analysis is a highly efficient and comprehensive method for proteomic research. This approach employs mass spectrometry to examine complex protein mixtures, with a fundamental strategy involving enzymatic digestion of proteins, followed by mass spectrometric analysis and identification of the resulting peptides. Shotgun proteomic analysis is particularly effective for investigating intricate biological samples, including tissue extracts, cell lysates, and plasma. It enables the chara......
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• Drug Target Identification and Validation
Drug target identification and validation are integral steps in the drug development process. A drug target refers to a biological molecule or a group of molecules that play a crucial role in the onset and progression of a disease. Drugs achieve therapeutic effects by interacting with these targets. Validation confirms the function and biological significance of the identified targets, ensuring they can produce the anticipated therapeutic effects in both in vitro and in vivo experiments. The importanc......
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• Proteomic Analysis Mass Spectrometry
Proteomic analysis mass spectrometry is a powerful technique used to study the types, structures, functions, and interactions of proteins within cells, tissues, or organisms. As a central tool in proteomics research, mass spectrometry is widely applied across multiple fields, including biomedicine, drug development, disease diagnosis, and agricultural sciences. By employing high-precision mass measurements and advanced data processing techniques, proteomic analysis mass spectrometry can identify and q......
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PTM identification is a critical technique in modern proteomics. Post-translational modifications (PTMs) refer to the chemical modifications that proteins undergo after translation through enzymatic reactions, which can profoundly alter their properties and functions. PTMs are a key source of protein functional diversity in living organisms, regulating a range of biological processes, such as signal transduction, the cell cycle, metabolic control, and gene expression, by modifying protein structure, s......
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Proteomics quantification is a technique designed to measure the quantity of proteins in biological samples, with the primary aim of elucidating changes in protein roles across various biological processes. By assessing protein abundance quantitatively, either relatively or absolutely, this technique facilitates insights into biological function under different experimental or natural conditions. Proteomics quantification has a broad range of applications, including the identification of disease bioma......
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• Proteomics Target Identification
Proteomics target identification is pivotal in contemporary research within biomedical and life sciences, serving as a methodology to pinpoint protein targets linked to specific biological processes, diseases, or pharmacological actions. As primary agents of cellular functions, proteins play an indispensable role in organismal biology. Comprehensive insights into proteins involved in particular biological processes and their interactions are crucial for elucidating the molecular mechanisms underpinnin......
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• Protein Sequence Determination
Protein sequence determination is the process of identifying the sequence of amino acids in a protein molecule. This is crucial in fields such as molecular biology, structural biology, and biochemistry, as the function of a protein is inherently linked to its amino acid sequence. By determining this sequence, scientists can infer a protein's three-dimensional structure, its functional properties, and how it interacts within the cell. Furthermore, protein sequence determination is essential in medicine......
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• Proteomic Analysis of Exosomes
Proteomic analysis of exosomes is an integral technique in contemporary biomedical research, aimed at comprehensively characterizing the types and functions of proteins within exosomes. Exosomes are small vesicles, 30-150 nanometers in diameter, secreted by cells. They facilitate the intercellular and fluid-based transfer of biomolecules, including proteins, lipids, and nucleic acids. Playing pivotal roles in cell communication, waste removal, and immune response regulation, exosomes are crucial for u......
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Proteomics LC-MS/MS analysis is a powerful tool for comprehensive protein profiling and identification in biological samples. LC-MS/MS, which stands for liquid chromatography-tandem mass spectrometry, enables the separation, detection, and characterization of complex protein mixtures. This technique provides critical insights into protein identification, quantification, and post-translational modifications, playing a pivotal role in elucidating protein function, cellular signaling pathways, and diseas......
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• Protein Thermal Stability Assay
The protein thermal stability assay is a critical method for examining the structural and functional resilience of proteins under conditions of thermal denaturation. This technique involves applying heat to assess structural changes in proteins, thereby evaluating how different temperatures influence their stability. Protein thermal stability is defined as the capacity of a protein to preserve its native conformation and function at elevated temperatures. This assay is extensively employed in drug dev......
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