Resources
Proteomics Databases
Metabolomics Databases
-
Disease proteomics is concerned with the systematic study of proteins and their expression patterns related to diseases. This field aims to uncover the mechanisms of disease occurrence and progression, as well as the characteristics of biomarkers. Unlike traditional genomic research, disease proteomics focuses on protein functions, interactions, modifications, and their roles in disease processes. Proteins, being the products of gene expression, play critical biological roles both inside and outside t......
-
DIGE 2D gel electrophoresis is a classic protein separation technique that plays a crucial role in proteomics research. Utilizing two orthogonal separation mechanisms-Isoelectric Focusing (IEF) and SDS-PAGE (Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis)-this method effectively separates proteins on a two-dimensional plane. This allows for the clear analysis of thousands of proteins in complex samples. Since its inception in the 1970s, it remains an essential tool in proteomics due to its ......
-
Differential proteomics analysis involves using quantitative proteomics techniques to study protein expression changes under various physiological or pathological conditions, aiming to identify proteins with significant expression differences. Unlike traditional molecular biology methods, differential proteomics provides a comprehensive view of the dynamic changes in hundreds or thousands of proteins, thus elucidating their roles in biological processes. This approach is applicable across numerous fie......
-
• Differential Expression Proteomics
Differential expression proteomics involves systematically analyzing protein expression levels in various biological conditions-such as health versus disease, treated versus control groups, and different developmental stages-using advanced proteomic technologies. This approach aims to identify proteins with significantly altered expression patterns across these states. At its core, differential expression proteomics utilizes high-resolution mass spectrometry along with sophisticated bioinformatics to ......
-
Diabetes proteomics employs high-throughput protein analysis techniques to investigate the protein changes associated with the onset, progression, and complications of diabetes. This approach allows for a comprehensive analysis of the differences in protein expression levels between diabetic patients and healthy individuals, thereby uncovering critical biological processes and molecular mechanisms. With the rapid advancements in mass spectrometry and bioinformatics, diabetes proteomics has become a cr......
-
• DIA Proteomics Service: Advancing Disease Research
The DIA proteomics service represents an advanced mode of mass spectrometry data acquisition that has recently garnered significant attention in the field of life sciences. The choice of data acquisition methodology in proteomics research is crucial as it directly impacts the depth and precision of protein identification. Traditional DDA (Data-Dependent Acquisition) methods are limited by their reliance on predefined mass spectrometry screening criteria, which often results in the omission of low-abun......
-
• Membrane Protein Mass Spectrometry
Membrane protein mass spectrometry has emerged as a significant technique in recent proteomics research, facilitating the analysis and characterization of proteins within biological membranes. Membrane proteins, which are integral to cell membranes and subcellular membranes, perform crucial roles such as signal transduction, substance transport, and cell recognition. The inherent complexity, structural diversity, and hydrophobic nature of membrane proteins present notable challenges for traditional pr......
-
DIGE proteomics is a method for analyzing protein expression changes via differential gel electrophoresis, which highlights proteomic differences across various biological samples. The acronym DIGE refers to Difference Gel Electrophoresis, a technique employing fluorescent labeling of proteins from different samples. This approach allows simultaneous separation and quantitative analysis through fluorescence scanning within the same gel. By facilitating the concurrent analysis of multiple samples, DIGE......
-
• Membrane Protein Identification
Membrane protein identification involves recognizing and analyzing proteins located on biological membranes using various experimental techniques and bioinformatics methods. These proteins not only provide structural support to cell membranes but also engage in crucial biological processes such as signal transduction, transport of substances, and cell recognition. Understanding membrane proteins is therefore essential for comprehending cellular functions and biological processes. In the medical field,......
-
Co-IP results refer to the protein interaction data obtained from Co-immunoprecipitation (Co-IP) experiments, which include the identification of the target protein and its binding partners. Co-immunoprecipitation is a technique based on the specific binding between antigens and antibodies, used to study the composition and interactions of protein complexes. This technique enriches the target protein and its interaction partners under near-physiological conditions, and subsequent analysis using Wester......
How to order?
