Resources

Proteomics Databases



Metabolomics Databases

• • Detection and Analysis of Glycoproteins Based on HCD/ETD Mass Spectrometry

  Glycoproteins play crucial roles in various physiological functions, including cell communication, immune response, and protein stability regulation. Given their structural complexity and key roles in biological functions, the detection and analysis of glycoproteins have become a significant focus in biological research.

• • Quantitative Analysis of Phosphoproteins Using iTRAQ/TMT Labeling

  Protein phosphorylation is a critical post-translational modification involved in numerous physiological processes, including cellular signal transduction and regulation. Accurately quantifying the phosphorylation status of proteins is essential for understanding their functional roles within biological systems.

• • Detection of Low Abundance Phosphoproteins Using TiO2 and IMAC

  Protein phosphorylation is a critical post-translational modification widely present in cells, influencing various biological processes such as signal transduction, cell cycle regulation, and metabolism. The study of phosphorylated proteins is essential for understanding the regulatory mechanisms behind these processes.

• • Procedure of Membrane Protein Purification with Detergent Optimization

  Membrane proteins play a critical role in cellular processes, including signal transduction, transport of molecules, and energy transduction. Despite their significance, purifying these proteins in a functional state remains a challenging endeavor. The delicate balance between maintaining protein stability and functionality during extraction and purification processes is paramount.

• • MALDI-TOF Analysis of Peptide Mass Fingerprinting

  Peptide Mass Fingerprinting (PMF) is a widely used analytical method for protein identification based on mass spectrometry. Among the various techniques employed, Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) has emerged as a prominent tool. This technique enables the rapid identification of proteins by measuring the masses of peptide fragments and comparing them with reference databases.

• • Analysis of Membrane Proteins Using Affinity Purification Tags

  Membrane proteins are integral to cellular function, acting as gatekeepers and communication hubs for cells. Despite their importance, studying these proteins poses significant challenges due to their complex nature and the intricate environments they inhabit. Advances in affinity purification tags have revolutionized the analysis of membrane proteins, offering researchers powerful tools to unravel their mysteries.

• • Mechanism of Cell Surface Proteomics

  Cell surface proteomics is an essential field studying proteins expressed on the cell surface and their interactions. These proteins play critical roles in intercellular communication, immune responses, and disease progression. Understanding these mechanisms not only reveals fundamental biological principles but may also provide a basis for the development of new therapies.

• • Application of Cell Surface Proteomics

  Cell surface proteomics is a discipline that studies the proteins located on the cell membrane, encompassing their structure, function, and roles in intercellular interactions. Cell surface proteins play crucial roles in various biological processes, including cell signaling, immune responses, and communication between cells. Therefore, understanding these proteins' functions and their alterations in diseases is of great importance for biomedical research and clinical applications.

• • Workflow of Cell Surface Proteomics

  Cell surface proteomics is an important field in biological research, providing insights into cellular functions, signal transduction, and the role of proteins in diseases.

• • Mechanism of Exosome Proteomics

  Exosomes are small membrane vesicles released by cells, ranging in size from approximately 30 to 150 nanometers, and are widely found in various biological fluids, such as blood, urine, saliva, and breast milk. They play crucial roles in intercellular signaling, material transport, and immune regulation. In recent years, exosomal proteomics has emerged as a significant research field, attracting considerable attention from the scientific community.