Resources
Proteomics Databases
Metabolomics Databases
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Protein network mapping involves the systematic investigation of protein interactions to create functional association networks that uncover the intricate mechanisms of intracellular signal transduction, metabolic regulation, and disease progression. In cellular biology, functions are typically executed by a coordinated effort of multiple proteins rather than by individual proteins in isolation. Therefore, exploring protein interactions and their network relationships is crucial for understanding the ......
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• Biomarker Discovery Proteomics
Biomarker discovery proteomics is a scientific discipline that employs proteomic techniques to screen, identify, and validate biomarkers, aiming to uncover key protein molecules involved in disease states, drug responses, or physiological processes. Biomarkers refer to biological molecules that can be objectively measured to assess normal biological processes, pathological states, or responses to therapeutic interventions. Proteins, being the primary functional molecules in living organisms, provide i......
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Deep proteomics is an advanced technology in proteomics, focusing on the comprehensive analysis of protein diversity, expression levels, post-translational modifications, and interactions within biological samples. Unlike traditional proteomic methods, deep proteomics employs highly sensitive and high-resolution mass spectrometry, alongside optimized techniques for sample preparation, separation, and data analysis. This approach allows for a more complete and precise characterization of the proteome i......
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• Absolute Protein Quantification Mass Spectrometry
Absolute protein quantification mass spectrometry is a powerful technique for the precise quantitative analysis of proteins in complex biological samples. It finds extensive application in biomedical research, drug development, and clinical diagnostics. By leveraging this technology, researchers can accurately determine the absolute concentration of proteins within a sample, providing critical data for early disease diagnosis, drug efficacy evaluation, and biomarker discovery. This method not only aid......
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Alkylation proteomics is a specialized area of proteomics that focuses on the study of protein alkylation modifications. This field mainly utilizes high-resolution mass spectrometry to identify alkylation modification sites, patterns, and their biological functions. Alkylation modifications are covalent alterations where alkyl groups, such as methyl or ethyl, are introduced into the side chains or main chains of amino acids within proteins. This can impact protein structure, stability, interactions, a......
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• Comprehensive Characterization of Protein-Protein Interactions Perturbed by Disease Mutations
The comprehensive characterization of protein-protein interactions perturbed by disease mutations is crucial for understanding disease pathogenesis, identifying potential therapeutic targets, and developing new treatments. Protein-protein interactions are fundamental to the biological functions in organisms, with nearly all life processes depending on the complex and precise interactions between proteins. However, mutations in genes, especially those associated with diseases, often disrupt these inter......
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• Protein-Protein Interaction Services
Protein-Protein Interactions play a critical role in regulating physiological activities, biochemical reactions, and signal transduction processes within organisms. Protein-Protein Interaction Services enable researchers to identify, analyze, and comprehend the complexity of these interactions. By utilizing these services, scientists can predict potential biological roles, elucidate underlying mechanisms, and identify novel therapeutic targets. As such, Protein-Protein Interaction Services are widely ......
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• Biosimilar Antibody Sequencing
Biosimilar antibody sequencing refers to the detailed analysis of the DNA and protein sequences of biosimilar antibodies. As the biopharmaceutical field continues to grow, antibody biologics are becoming increasingly important in treating various diseases. However, due to the high costs of development, complex clinical trials, and lengthy timeframes, the emergence of biosimilars provides a promising solution to reduce treatment costs and improve drug accessibility. The aim of biosimilar antibody seque......
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Whole proteome analysis is a proteomics research approach based on mass spectrometry technology, designed to systematically examine the types, quantities, functions, and interactions of all proteins within biological organisms or cells. Unlike traditional targeted protein analysis, whole proteome analysis offers a comprehensive tool for understanding the functions and mechanisms of biological systems by identifying and quantifying all proteins in complex biological samples. This technique has broad ap......
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• Autoantibody Biomarker Discovery
Autoantibody biomarker discovery is a multifaceted process that integrates various technical approaches, alongside stringent validation and mechanistic studies, to ensure the clinical relevance of the identified biomarkers. Detecting specific autoantibodies in the human body offers a valuable tool for diagnosing numerous diseases. Autoantibodies are produced by the immune system against the body’s own tissues during immune dysfunction. These antibodies serve as hallmark markers of autoimmune diseases,......
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