Resources

Proteomics Databases



Metabolomics Databases

• • Phylogenetic Analysis of Protein Sequences

  Phylogenetic analysis of protein sequences involves comparing protein sequences from different species or gene families to infer evolutionary relationships. This approach helps elucidate functional changes in proteins and the mechanisms underlying their adaptation during evolution. Initially, phylogenetic analysis was primarily used in taxonomy, where evolutionary trees were constructed based on morphological characteristics. However, with advancements in molecular biology, genetic and protein sequence.....

• • Protein Identification by Peptide Mass Fingerprinting

  Protein identification by peptide mass fingerprinting is a mass spectrometry-based approach for efficient protein identification. This method involves enzymatic cleavage of proteins into specific peptides, followed by mass spectrometric analysis to generate a unique peptide mass fingerprint. The resulting fingerprint is then compared with theoretical peptide mass data from protein databases to determine protein identity. Due to its high throughput, rapid analysis, and relatively simple experimental ........

• • Single-Cell Proteomics Mass Spectrometry

  Single-cell proteomics mass spectrometry is a mass spectrometry-based approach designed to characterize the protein composition and dynamic changes within individual cells. Conventional proteomics techniques typically require large cell populations, whereas single-cell proteomics mass spectrometry overcomes this limitation by enabling the analysis of protein expression levels, post-translational modifications, and protein-protein interactions at single-cell resolution. This technology provides an .......

• • PY-GC-MS Analysis

  PY-GC-MS Analysis is an analytical technique that integrates pyrolysis, gas chromatography (GC), and mass spectrometry (MS). This method enables efficient and precise analysis of complex organic compounds, leading to its widespread application in various scientific and technological fields. In materials science, PY-GC-MS Analysis is extensively utilized to investigate the composition and degradation behavior of polymers. By analyzing the decomposition products, researchers can infer structural information..

• • Glycan Analysis Mass Spectrometry

  Glycan analysis mass spectrometry is a highly sensitive analytical technique employed to elucidate the structural characteristics and variations of glycans. Glycans are ubiquitous in biological systems and play essential roles in various biological processes, including cell signaling, immune response, protein folding, and cell-cell interactions. Compared to proteins and nucleic acids, glycans exhibit remarkable structural complexity and heterogeneity. Traditional glycan analysis techniques often struggle...

• • Single Reaction Monitoring

  Single reaction monitoring (SRM) is a mass spectrometry-based technique for the quantitative analysis of target compounds or biomolecules. Compared to conventional mass spectrometry techniques, single reaction monitoring offers superior sensitivity and specificity, enabling precise identification and quantification of specific molecules in complex biological matrices. The core principle of single reaction monitoring involves the selective detection of target analytes by monitoring predefined ion ........

• • Metabolic Pathway Analysis

  Metabolic pathway analysis is a scientific approach for investigating metabolic processes, metabolite transformations, and regulatory networks within cells or organisms. A metabolic pathway consists of a series of enzyme-catalyzed chemical reactions that facilitate the conversion of substrates into products, thereby sustaining essential biological functions such as energy homeostasis, biosynthesis, and signal transduction. In addition to nutrient metabolism, metabolic pathways play a crucial role in .......

• • Olink Proximity Extension Assay

  The olink proximity extension assay is an advanced proteomics technology designed for accurate and efficient protein quantification. Based on the principle of proximity extension, this method integrates high-throughput microfluidic systems with a highly sensitive real-time quantitative PCR (qPCR) detection system. This combination enables the simultaneous detection of multiple target proteins within complex biological samples. The assay is distinguished by its high specificity and sensitivity, allowing.....

• • Immune Response Profiling

  Immune response profiling involves analyzing immune responses triggered by antigen stimulation using a range of advanced techniques. As a fundamental defense mechanism against pathogens, the immune response comprises intricate cellular and molecular interactions. By leveraging immune response profiling, researchers can gain deeper insights into immune system mechanisms, immune cell activation and function, as well as the proteins and signaling pathways involved in these processes. This approach is .........

• • Biomolecular Target Identification

  Biomolecular target identification is the process of systematically identifying molecular targets associated with specific biological processes or disease states using experimental methodologies. This process plays a crucial role in modern medicine and drug development. In cancer research, identifying molecular targets specific to tumor cells enables researchers to design highly selective and effective targeted therapies, thereby minimizing damage to normal cells. Similarly, in the study of .......