Resources

Proteomics Databases



Metabolomics Databases

• • Workflow of Cellular Proteomics

  Cellular proteomics is an important field that studies the composition, function, and interactions of all proteins within cells. By systematically analyzing cellular proteins, scientists can gain insights into biological processes and their roles in diseases.

• • Application of Cellular Proteomics

  As high-throughput technologies evolve rapidly, the field of cellular proteomics has revealed substantial potential across both fundamental research and clinical applications.

• • Principle of Cellular Proteomics

  Cellular proteomics is a crucial field focused on the composition, structure, function, and interactions of proteins within cells. 

• • Analysis of Methylated Proteins Using Orbitrap Fusion Lumos

  Methylation is a critical post-translational modification (PTM) of proteins that plays an essential role in regulating gene expression, cell signaling, and protein function. Protein methylation primarily occurs on lysine and arginine residues, and its dynamic changes are closely associated with the development of various diseases, such as cancer and neurodegenerative disorders.

• • Procedure of Quantitative Acetylomics Based on LC-MS/MS

  Protein acetylation is a common post-translational modification (PTM) that plays a crucial role in cellular function regulation. The dynamic regulation of acetylation is involved in various biological processes, including gene expression, cell cycle control, metabolic pathways, and signal transduction. Therefore, mapping the global acetylation landscape is essential for understanding intracellular regulatory mechanisms and the molecular basis of diseases.

• • Detection of Protein Methylation Based on LC-MS/MS

  Protein methylation is one of the critical post-translational modifications that regulate various biological processes, including gene expression, signal transduction, and protein-protein interactions. This modification primarily occurs on lysine and arginine residues through the transfer of methyl groups by methyltransferases, resulting in mono-, di-, or trimethylation.

• • Quantitative Analysis of Protein Acetylation Using Acetylomics

  Acetylation is a key post-translational modification that plays a significant role in regulating various biological processes, including gene expression, cell cycle control, metabolism, and stress responses. Typically occurring on lysine residues, acetylation modifies protein structure and function through the addition of an acetyl group, which in turn influences cellular physiology.

• • Analysis of Acetylation Sites Using Acetyl-proteomics

  Protein acetylation is a critical post-translational modification that plays a pivotal role in cellular processes such as metabolism, signal transduction, and gene expression regulation. The analysis of acetylation sites provides insights into the regulatory mechanisms of protein functions and uncovers molecular pathways involved in various diseases.

• • Quantitative Analysis of Glycoproteins Using Nano-LC and Orbitrap Fusion

  Glycoproteins are proteins that play crucial roles in biological processes, with glycosylation modifications affecting protein structure, stability, and function. Aberrant glycosylation is associated with various diseases, including cancer, diabetes, and neurodegenerative disorders, making glycoprotein analysis important in both basic research and clinical diagnostics. Due to the structural complexity and heterogeneity of glycoproteins, traditional analytical methods often fall short in accurately character

• • High-Throughput Identification and Quantification of Ubiquitinated Proteins

  Ubiquitin is a small, highly conserved protein found in all eukaryotes, playing pivotal roles in a range of biological processes including protein degradation, regulation of the cell cycle, DNA repair, and signal transduction. Ubiquitination involves the covalent attachment of ubiquitin to substrate proteins, which can tag them for degradation via the proteasome or alter their activity, localization, or interactions.