Resources
Proteomics Databases
Metabolomics Databases
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Native proteomics involves the systematic analysis and study of proteins without altering their three-dimensional structure. This approach is applicable not only to individual protein studies but also to the analysis of protein networks and inter-protein interactions. Proteins typically perform cellular functions by forming complexes with other proteins or molecules, and many biological processes, including signal transduction, gene expression regulation, and cell cycle control, depend on precise prot......
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Orbitrap proteomics is a method that systematically analyzes the proteome using Orbitrap high-resolution mass spectrometry. This advanced Fourier transform mass analyzer is notable in proteomics research for its exceptional resolution, accuracy, and sensitivity. Unlike traditional quadrupole or time-of-flight (TOF) mass spectrometers, Orbitrap technology can accurately measure the mass of proteins and peptides over a broad dynamic range with high quantitative precision, thus enhancing the reliability ......
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Label-free LC-MS/MS (Liquid Chromatography-Tandem Mass Spectrometry) is an efficient analytical approach that integrates liquid chromatography (LC) with mass spectrometry (MS) to enable high-precision qualitative and quantitative analysis of components within complex biological samples. The primary advantage of label-free LC-MS/MS is its ability to analyze samples without the need for chemical labeling or pretreatment, allowing direct separation and analysis. This methodology enables researchers to id......
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Metaproteomic analysis technology involves the comprehensive and systematic examination and quantification of all proteins within an organism, focusing on their composition, structure, function, and interactions using advanced mass spectrometry, liquid chromatography, and other high-throughput analytical methods. Unlike genomics and transcriptomics, this approach provides direct insights into the expression and biological roles of proteins, offering a deeper understanding of cellular physiological and......
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Fungal proteomics is a field dedicated to the comprehensive analysis of all proteins within fungal cells, utilizing high-throughput technologies. Unlike genomics, which focuses on the genes of organisms, proteomics emphasizes the expression, function, interactions, and post-translational modifications of proteins. Fungi, as microorganisms, play significant roles in ecology, agriculture, and medicine. By studying fungal proteomes, scientists can gain valuable insights into the functions of various prot......
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• Primary Structure Analysis: Key to Protein Function and Drug Design
Primary structure analysis is a pivotal technique in proteomics, focusing on detailed examination of protein molecules' amino acid sequences. Proteins execute nearly all cellular activities, such as catalyzing reactions, providing structural integrity, regulating gene expression, and transporting molecules. The function of a protein is intrinsically linked to its amino acid sequence, with even minor alterations potentially leading to significant functional changes. By elucidating the primary structure......
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Total protein analysis determines the overall protein content in a sample. Proteins are fundamental to life, participating in nearly all physiological processes, including metabolism, signal transduction, immune response, and cellular structure maintenance. By conducting total protein analysis, researchers can gain insights into the overall protein expression levels within cells, tissues, or organisms, which is crucial for biological research, disease diagnosis, and drug development. Clinically, it is......
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Peptide-based drug design represents an innovative approach in drug development, utilizing the distinctive biological activity and specificity of peptide molecules to create therapeutics with enhanced efficacy and minimized side effects. Composed of amino acids, peptide molecules feature unique three-dimensional configurations that facilitate precise interactions with target molecules such as proteins, receptors, and enzymes, thereby influencing their biological activities. In peptide-based drug desig......
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Primary sequence analysis is a fundamental and crucial step in proteomics research, involving the detailed examination and interpretation of protein amino acid sequences. This process serves as the starting point for elucidating protein function and understanding complex molecular mechanisms within organisms. The primary objective of this analysis is to accurately map the positions and order of amino acids in proteins. Advances in technology have enhanced the efficiency and precision of this process. ......
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The amino acid analysis test is essential for elucidating the structure and function of biomolecules by determining the composition and concentration of amino acids in a given sample. Precise amino acid analysis tests are widely applied in fundamental research, medical diagnostics, food safety assessment, and biotechnology development. In fundamental research, the amino acid analysis test aids in a deeper understanding of protein structure and function. By analyzing the amino acid composition derived ......
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