Resources

Proteomics Databases



Metabolomics Databases

• • Mechanism of De Novo Protein Sequencing

  De Novo Protein Sequencing is a method for protein sequence analysis that does not rely on existing databases.

• • Workflow of De Novo Protein Sequencing

  Proteins are the main functional molecules within organisms, and their amino acid sequences determine their three-dimensional structures and biological functions. Therefore, deciphering the amino acid sequences of proteins is crucial for understanding their functions.  

• • Application of De Novo Protein Sequencing

  De novo protein sequencing does not depend on databases and can directly decode unknown protein sequences.

• • Advantages and Disadvantages of De Novo Protein Sequencing

  Traditional protein sequencing methods primarily rely on existing protein databases for matching and identification, but these methods have significant limitations for proteins and antibodies with unknown sequences.

• • Principle of De Novo Protein Sequencing

  Generally, there are two methods for protein sequence analysis: database search and de novo sequencing. The database search method identifies proteins by measuring peptide mass and comparing it to available protein databases.

• • Circular Dichroism Analysis of Antibody Drug

  Antibody drugs, including monoclonal antibodies and polyclonal antibodies, are a category of drugs that use antibody molecules for the treatment of diseases. They are widely used in the treatment of various diseases such as cancer, infectious diseases, and autoimmune diseases. The advantages of antibody drugs include high specificity and affinity, low toxicity and side effects, long half-life in the body, and good biocompatibility.

• • Nuclear Magnetic Resonance Analysis of Antibody Drug

  Monoclonal antibodies, artificially synthesized antibodies used to treat diseases, specifically bind to target molecules to achieve therapeutic effects. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, and antibody-drug conjugates. Antibody drugs have shown significant efficacy in treating various diseases such as cancer, autoimmune diseases, inflammatory diseases, immune regulation, and ophthalmic diseases.

• • Infrared Spectral Analysis of Recombinant Protein Drugs

  Recombinant protein drugs refer to protein products derived from animals and plants through biotechnological research and development, which have certain biological activities and can prevent, diagnose, and treat human, animal, and plant diseases. Compared to small molecule drugs, recombinant protein drugs have advantages such as high activity, high specificity, and low toxicity, making them favored by researchers.

• • Application of Cross-Linking Protein Interaction Analysis

  Protein-protein interactions are critical in the life processes of organisms. To gain deeper insights into these interactions, scientists have developed various analytical methods, with cross-linking technology being particularly notable for stabilizing transient or weak interactions.

• • Mechanism of Cross-Linking Protein Interaction Analysis

  In the field of life sciences, understanding protein-protein interactions (PPIs) is crucial. These interactions reveal the molecular basis of biological processes and offer critical insights into the mechanisms underlying various diseases. Cross-linking technology is a vital tool for studying PPIs. By introducing covalent bonds between proteins or protein complexes, it stabilizes their interactions, enabling researchers to identify the components and spatial arrangements of these complexes.