Resources

Proteomics Databases



Metabolomics Databases

• • Introduction and Applications of CUT&Tag Technology

  CUT&Tag (Cleavage Under Targets and Tagmentation) is an advanced technique designed for the study of DNA-protein interactions, primarily employed to identify the binding sites of transcription factors or histone modifications across the entire genome. The core principle of CUT&Tag involves the use of antibodies to specifically recognize target proteins or chromatin modifications, followed by the action of the Tn5 transposase, which generates sequencing-compatible tags at these binding sites. First......

• • The Hot Topic in Chromatin Biology: Insights into Histone Modification and CUT&Tag

  Histone modifications are essential regulators of chromatin structure and gene expression, playing crucial roles in maintaining cellular function, genomic stability, and facilitating processes such as cell differentiation. Within the cell nucleus, DNA directs the synthesis of RNA and proteins, ensuring proper organismal function. DNA exists as a double helix and wraps around histones to form nucleosomes, which serve as the fundamental units of chromatin. Nucleosomes are organized into a bead-on-a-string...

• • Protein Characterization Services

  Protein characterization services encompass analytical techniques designed to determine the physicochemical properties, structural features, and biological functions of proteins. As essential functional molecules in living organisms, proteins exhibit diverse structures and functions that underpin their critical roles in biological processes. Accurate protein characterization is vital for understanding protein behavior in cellular systems, tracking protein alterations in disease states, and identifying......

• • Native Mass Spec

  Native mass spectrometry (native MS) is a biochemical research technique that enables scientists to analyze proteins without altering their native structure. This method's core advantage is its ability to maintain the protein's original conformation and functional state, ensuring more accurate and reliable data. Traditional denaturing mass spectrometry often involves disrupting the protein's native conformation to facilitate detection, which can lead to the loss of key structural information or altera......

• • Peptide Sequencing by Mass Spectrometry

  Peptide sequencing by mass spectrometry is an analytical technique used to determine the amino acid sequence of proteins and identify their structural features. The core principle involves precise mass measurements of enzyme-digested protein fragments (peptides) using a mass spectrometer, enabling the deduction of the amino acid sequence of the peptide chain. This technology has wide-ranging applications. In basic research, it enables the identification and quantitative analysis of complex protein int......

• • Mass Spectrometry Quantification

  Mass spectrometry quantification is a widely used technique for protein quantification in biological samples. It provides both relative and absolute protein quantification data, enabling researchers to investigate complex biological processes comprehensively. This method finds extensive applications in biomarker discovery, disease mechanism research, drug target identification, and pharmaceutical development. In medicine, mass spectrometry quantification enhances our understanding of disease pathogene......

• • MS Protein Identification

  MS protein identification involves measuring the mass-to-charge ratio (m/z) of proteins or protein fragments to determine their molecular mass and infer structural characteristics. Mass spectrometry provides high sensitivity, making it a powerful tool for detecting and identifying proteins in complex biological samples.   In the biomedical field, MS protein identification is widely applied in disease biomarker discovery, drug mechanism research, and personalized medicine. By analyzing protein expressi......

• • Interactome Analysis

  Interactome analysis refers to the study of interactions between proteins and other biomolecules (including proteins, nucleic acids, and lipids) within an organism. Proteins are key molecules responsible for most cellular functions, and their activities depend on forming intricate networks with other biomolecules. Consequently, interactome analysis is essential for elucidating mechanisms underlying intracellular signal transduction, metabolic pathways, and gene expression regulation.   This technology......

• • LC-MS Protein Quantification

  LC-MS protein quantification integrates liquid chromatography (LC) and mass spectrometry (MS) to identify and quantify proteins in complex biological samples with high accuracy and sensitivity. Liquid chromatography separates proteins or peptides based on their chemical and physical properties, enabling the gradual isolation of individual components from complex samples. This sequential separation allows mass spectrometry to more precisely identify and quantify proteins or peptides. Mass spectrometry,......

• • Antibody Epitope Mapping in Research and Diagnostics

  Antibody epitope mapping is a critical technique for identifying and analyzing the interactions between antibodies and their target proteins. An epitope refers to a specific region on an antigen molecule that antibodies can bind with high specificity. Detailed analysis of these epitopes provides insights into antibody specificity and functional properties, playing pivotal roles in basic research, vaccine development, and disease diagnostics.   In basic research, antibody epitope mapping facilitates th......