Resources

• • Uncovering Key Information About Disease Mechanisms Using Protein Quantitative Mass Spectrometry

  Proteins are important functional molecules in living organisms. This makes protein quantitative mass spectrometry important and widely applicable in revealing disease mechanisms. Through this technology, key information can be obtained to study the molecular mechanisms of disease occurrence and development. At the same time, understanding the quantitative changes in proteins during disease processes is also of great significance for finding new therapeutic targets and personalized medicine.   Proteom......

• • In-depth Exploration of the Accuracy and Reliability of Protein N-terminal Sequencing Technology

  Protein N-terminal sequencing technology aims to determine the starting amino acid residue of protein molecules. Commonly used techniques include N-terminal microsequencing, protein digestion and mass spectrometry. These techniques can analyze the amino acid sequence at the N-terminal of proteins, revealing the starting position of proteins.   Service Advantages 1. Accuracy Protein's N-terminal sequencing has high accuracy in determining the starting position of proteins. By combining different experi......

• • Hydrogen-Deuterium Exchange Mass Spectrometry and Protein Interaction

  Over the past few decades, scientists have developed many tools and techniques for studying protein interaction, among which Hydrogen Deuterium Exchange Mass Spectrometry (HDXMS) is a very useful method.   Hydrogen Deuterium Exchange Mass Spectrometry is a method of studying the structure and interaction of proteins by measuring the rate of hydrogen-deuterium exchange in proteins. In the process of hydrogen-deuterium exchange, the exchangeable hydrogen atoms in proteins will exchange with deuterium in......

• • Application and Optimization of Co-Immunoprecipitation Technology in Proteomics Analysis

  Co-immunoprecipitation is an useful technique for proteomics analysis. Protein interaction is an important way of molecular communication within cells. Co-Immunoprecipitation, as a commonly used technique for studying protein interactions, can selectively precipitate target proteins and their interaction partners by utilizing the specificity of antibodies.   Principles of Co-Immunoprecipitation 1. Selectivity of Antibodies Immunoprecipitation depends on the specificity of antibodies. Choosing an antib......

• • Protein Mass Spectrometry Detection Methods Introduction

  Protein mass spectrometry detection is one of the essential techniques in the field of biopharmaceuticals. It not only assists us in identifying and quantifying protein samples but also reveals information about protein structures, modifications, and interactions.   This technique is based on mass spectrometry, analyzing the ion characteristics in protein samples to collect information about their structure and composition. The basic principle involves the following steps: 1. Sample Preparation Dissol......

• • How to Accurately Detect Protein Primary Structure?

  Accurately determining protein primary structure is an important task in the field of bioproducts.    Amino Acid Analysis Amino acid analysis is the basis for determining the primary structure of proteins by determining the types and relative content of various amino acids in the protein. Commonly used amino acid analysis techniques include High-Performance Liquid Chromatography (HPLC) and Capillary Electrophoresis (CE). These techniques can separate and quantify the amino acids in protein samples, th......

• • Protein Peptide Sequencing Technology Analysis

  Understanding the peptide sequence of proteins is of great significance for understanding the function, structure, and disease mechanisms of organisms. The peptide sequence of proteins is composed of amino acids, and through sequencing techniques, we can reveal their accurate order. This article will focus on protein peptide sequencing techniques, providing a detailed introduction to how peptide sequences are determined and discussing how these techniques help us unravel the mystery of protein coding......

• • Can Proteome Sequencing Reveal Differences in Proteins Between Cells?

  Proteome sequencing technology is a high-throughput method, widely used in the study of protein composition and expression levels. Cell is the basic unit of life, and protein, as an important component of the cell, plays various key functions within the cell. Understanding the differences of proteins between cells is crucial for revealing the diversity of life, the occurrence and development of diseases, and the development of personalized treatment methods.   Proteomics Sequencing Methods The methods......

• • How Many Samples Are Suitable for a Single Circular Dichroism Experiment?

  In practical applications, researchers often need to analyze multiple samples. However, determining how many samples are suitable for a single Circular Dichroism experiment is a crucial question. We will consider this issue from the following factors.   Impact of Sample Quantity on Experimental Results The quantity of samples has some impact on the results of circular dichroism analysis. When analyzing multiple samples at once, it's necessary to consider the differences and variability between the sam......

• • Breakthrough in Protein Sequencing: Unraveling Complex Proteomes

  Analyzing the composition and function of complex proteomes is a significant challenge in modern life sciences. Advances in protein sequencing technology provide support for unveiling the mysteries of complex proteomes.    Development 1. First Generation Sequencing Technologies Early protein sequencing technology mainly relied on Edman degradation, which could determine the amino acid sequence of proteins but was limited by sequencing length and the degree of automation.   2. Second Generation Sequenc......