Resources
Proteomics Databases
Metabolomics Databases
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ABPP proteomics, short for activity-based protein profiling, is an advanced chemical probe-based technology designed to investigate protein functional states and activities. It enables monitoring and regulation of protein activity by employing specialized chemical probes that form stable covalent bonds with active sites in proteins. This approach is widely applied in modern biomedical research, particularly in drug discovery, disease mechanism elucidation, and biomarker identification. At the heart of......
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LC-MS proteomics is an analytical technique that integrates liquid chromatography (LC) and mass spectrometry (MS) to comprehensively study proteins in complex biological samples. At its core, this technology harnesses the separation efficiency of LC and the identification precision of MS, enabling scientists to perform protein identification, quantification, and post-translational modification analyses. LC-MS proteomics is indispensable in proteomic research, offering insights into intracellular prote......
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• Identification of Drug Targets
The identification of drug targets involves determining biomacromolecules, such as proteins, nucleic acids, and carbohydrates, that interact with drug molecules using various experimental and computational techniques. These targets are typically molecules associated with disease processes, playing critical roles in disease onset, progression, and development. As a cornerstone of drug discovery, target identification enhances our understanding of disease mechanisms, enables the identification of key mo......
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Isoform analysis refers to the identification, characterization, and quantification of compounds-known as isoforms-that share the same molecular formula but differ in their structures or spatial arrangements. In chemical and biological research, isoforms refer to molecules with identical chemical formulas but distinct molecular structures or stereochemical configurations. These structural differences often lead to significant variations in physicochemical properties, biological activities, metabolism,......
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The complete amino acid profile provides a detailed qualitative and quantitative analysis of both essential and non-essential amino acids, offering critical insights into protein composition and function. This analysis plays an essential role in fields such as protein research, biomedicine, food science, and agriculture. Amino acids, as the fundamental building blocks of proteins, are vital for numerous biological processes. Analyzing the complete amino acid profile allows researchers to understand pr......
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The protein pulldown assay is a widely employed in vitro technique for analyzing protein-protein interactions. By using a tagged bait protein to capture interacting partners, this method provides critical insights into protein relationships, binding affinity, and interaction specificity. Compared to yeast two-hybrid and co-immunoprecipitation assays, the protein pulldown assay offers direct and specific detection of interactions in a controlled environment. Its simplicity, high sensitivity, and abilit......
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Enzyme analysis involves investigating enzyme activity, kinetics, catalytic mechanisms, and regulatory effects (inhibition or activation) using a variety of experimental and technical approaches. Enzymes, which are protein or RNA molecules, act as biological catalysts, facilitating chemical reactions both intracellularly and extracellularly. They are often referred to as the "catalysts of life." The primary objective of enzyme analysis is to comprehensively understand enzymatic catalytic properties, r......
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• Transcriptomics and Proteomics
Transcriptomics and proteomics represent two complementary approaches for studying gene expression at different molecular levels. Transcriptomics focuses on RNA analysis to explore gene expression patterns, regulatory relationships, and the influence of environmental factors. In contrast, proteomics investigates the final gene expression products-proteins-examining their composition, structure, function, and interactions. As proteins directly execute cellular functions, proteomics offers critical ......
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• Overview of Full Amino Acid Profile
The full amino acid profile represents the qualitative and quantitative analysis of amino acids obtained by breaking down proteins into their individual amino acid components. This analysis reveals the amino acid composition of proteins and offers insights into their structure, function, and biological activity. The full amino acid profile is widely applied in proteomics, structural biology, and clinical diagnostics. By analyzing amino acid sequences and their proportions, researchers can est......
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Single-cell proteomics (SCP) represents a forefront area of biological research, dedicated to profiling protein expression patterns and their dynamics at the single-cell level. Traditional proteomics methods predominantly focus on population or tissue-scale analyses, limiting their capacity to resolve cellular heterogeneity. However, such heterogeneity is critical for understanding tissue functionality, biological mechanisms, and disease progression, underscoring the need for precise single-cell detec......
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