Resources
Proteomics Databases
Metabolomics Databases
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PFAS mass spectrometry is a crucial analytical technique for detecting and quantifying the widespread presence of PFAS compounds in the environment. Owing to their unique chemical stability and extensive industrial and consumer applications, PFAS are often referred to as "forever chemicals," with detectable traces across environmental matrices, industrial processes, and consumer products. However, their extreme persistence and resistance to degradation pose significant environmental and public health ......
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Gas chromatography–mass spectrometry (GC-MS) screening is an integrated analytical approach that combines gas chromatographic separation with mass spectrometric detection to identify and quantify compounds within complex sample matrices. Gas chromatography primarily serves to separate individual analytes present in a mixture, whereas mass spectrometry performs qualitative and quantitative analysis of the separated constituents. In the domain of environmental monitoring, GC-MS screening is extensively.......
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• Amino Acid Mass Spectrometry
Amino acid mass spectrometry refers to analytical methods utilizing mass spectrometry to achieve highly sensitive and specific qualitative and quantitative analysis of amino acids and their derivatives. As the fundamental building blocks of proteins, amino acids play critical roles in various biological processes, including metabolism, signal transduction, and the pathogenesis of diseases. Amino acid mass spectrometry enables accurate profiling of amino acid composition and concentration changes in trace...
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LCMS proteomics represents a cutting-edge analytical platform for characterizing protein composition and abundance within complex biological matrices. This approach has broad utility in biomedical research, offering insights into disease mechanisms and enabling the discovery of candidate biomarkers that facilitate the development of personalized medicine. For instance, by profiling proteomic alterations in cancer patients, researchers can identify proteins associated with disease progression, thereby.......
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• Biomarker-Based Drug Development
Biomarker-based drug development is a systematic approach that drives the discovery, validation, and clinical application of novel therapeutics through the identification and utilization of specific biomarkers. Biomarkers are typically defined as molecules or characteristics that objectively indicate physiological or pathological states within the body—such as proteins, nucleic acids, and metabolites—which are commonly found in biological samples including blood, urine, and tissue. The primary objective....
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Tandem Liquid Chromatography–Mass Spectrometry (LC-MS/MS) is a powerful analytical technique that integrates the separation efficiency of liquid chromatography (LC) with the sensitivity and specificity of tandem mass spectrometry (MS/MS). This method has been widely applied across diverse fields, including life sciences, pharmaceutical development, clinical diagnostics, environmental monitoring, and food safety. The core strength of Tandem LC-MS lies in its ability to first separate compounds in complex....
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• Single Crystal X-ray Structure Analysis
Single crystal X-ray structure analysis is a powerful technique for elucidating the atomic and molecular structures of substances. By analyzing the diffraction patterns of single crystal samples, researchers can precisely determine the spatial arrangement of atoms within the sample. This method not only reveals both intra- and intermolecular interactions but also provides detailed information on bond lengths and angles, laying a solid foundation for a deeper understanding of the chemical and physical ......
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Organelle proteomics refers to a research approach that systematically identifies, quantifies, and functionally annotates all proteins localized within specific organelles. Organelles, such as mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, and the nucleus, are subcellular structures responsible for executing diverse biological functions. The proteins constituting these organelles not only play essential roles in maintaining their individual functions but also participate in coordinated....
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• Biolayer Interferometry Data Analysis
Biolayer interferometry data analysis is a high-precision technique that utilizes the principles of optical interference to monitor biomolecular interactions in real time. By detecting the rate and extent of molecule binding or dissociation on a solid surface, it provides quantitative information on kinetic parameters such as the association rate constant (kon), dissociation rate constant (koff), and affinity constant (KD). Biolayer interferometry is an indispensable analytical tool in biochemical and......
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• Single Cell Whole Exome Sequencing
Single cell whole exome sequencing is a genomic technology focused on sequencing the exome at the resolution of individual cells. Exons represent the protein-coding regions of the genome, and even subtle variations in their sequences can profoundly alter protein structure and function, ultimately influencing vital biological processes. By leveraging single cell whole exome sequencing, researchers can investigate cellular heterogeneity in diseases such as cancer with unprecedented detail. This is parti......
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