Resources

• • Exploring Cellular Metabolic Regulation via Phosphoproteomics

  Cellular metabolism regulation is an important mechanism for maintaining cellular homeostasis and normal functioning. Protein phosphorylation, as an important signaling pathway, plays a crucial role in cellular metabolism regulation. Phosphoproteomics, as an emerging technology, provides an important tool for decoding the key codes of cellular metabolism regulation.

• • New Perspectives on Protein Ubiquitination Modifications

  Ubiquitination modification is an important protein regulatory mechanism in cells, playing a key role in regulating protein stability, cell signaling, DNA repair, and other biological processes. In recent years, with the development of ubiquitination proteomics technology, we can gain a deep understanding of the panorama and function of protein ubiquitination modification.

• • How to Select the Optimal Techniques for Ubiquitinomics Analysis?

  Ubiquitinomics analysis aims to comprehensively unravel the network of protein ubiquitination modifications, providing important clues to understand its regulatory mechanisms. This article will discuss how to select the optimal techniques and methods for ubiquitinomics analysis.

• • What Techniques are Available for Detecting Post-Translational Modifications?

  In the field of biopharmaceuticals, post-translational modification (PTM) detection is a critical step in quality control and drug development processes. PTM refers to a series of chemical modifications, such as glycosylation, phosphorylation, acetylation, etc., that occur on proteins after translation, thereby influencing protein structure, function, and stability. Accurate detection and analysis of PTMs are essential to ensure the safety, efficacy, and consistency of drugs.

• • Can Ubiquitin Detection Elucidate the Key Role of Protein Ubiquitination in Disease Progression?

  With the development of ubiquitin detection methods, researchers have started studying the crucial role of protein ubiquitination in disease progression. This article will discuss the importance and methods of ubiquitin detection, with a focus on whether ubiquitin detection can elucidate the key role of protein ubiquitination in disease development.

• • Isoelectric Point Determination of Antibody Drugs

  Antibody drugs are a class of drugs that are artificially synthesized antibodies used to treat diseases by specifically binding to target molecules. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, and antibody-drug conjugates. Antibody drugs have shown significant efficacy in treating various diseases such as cancer, autoimmune diseases, inflammatory diseases, immunomodulation, and ophthalmic diseases.

• • Methods for Detecting Ubiquitination Levels and Their Pros and Cons

  With the continuous development in the field of biopharmaceuticals, the study of protein regulation mechanisms has become increasingly important. In this process, the detection of ubiquitination levels has become a key technique, helping scientists understand the functionality of the ubiquitin system and its association with protein degradation and cellular processes.

• • Exploring Stable Interactions and Structural Changes Between Proteins Through Disulfide Bond Detection

  The disulfide bond is one of the important stabilizing factors in protein structure, playing a key role in maintaining the structure and function of proteins. The formation and breakage of disulfide bonds can lead to changes in protein structure, thereby affecting their interactions and functions. With the development of protein research, the detection of disulfide bonds has become an important technique for exploring protein stability and structural changes.

• • Analysis of Polysaccharide Binding Sites and Binding Ratios in Conjugate Vaccines

  Combination vaccine, also known as conjugate vaccine, such as pneumococcal vaccine, is a complex vaccine composed of antigen proteins and polysaccharide structures. It belongs to a special category of vaccines. The working principle of the combination vaccine is to attach small molecule antigens (usually polysaccharides) to large molecule carrier proteins, which can often induce strong immune reactions.

• • How Does Phosphoproteomics Aid in Deciphering Key Codes of Metabolic Regulation?

  Cellular metabolism regulation is an important process for maintaining life activities, which involves complex signaling networks and regulatory mechanisms. In recent years, phosphoproteomics has been widely used as a powerful tool to study the mechanisms of cellular metabolism regulation.