Resources

Proteomics Databases



Metabolomics Databases

• • Conformational Epitope Mapping

  Conformational epitope mapping systematically depicts the three-dimensional structural sites on an antigen's surface that are recognized and bound by specific antibodies. These epitopes are distinct regions formed by the protein's tertiary structure and play a vital role in antigen-antibody interactions. Unlike linear epitopes, conformational epitopes are composed of multiple non-contiguous amino acid residues brought together through spatial folding. Their complex stereostructure makes them essential......

• • De Novo Sequencing Proteomics

  De Novo Sequencing Proteomics is a technique used to deduce protein sequences directly from experimental data through mass spectrometry, in situations where genome sequences or reference protein databases are unavailable. Traditional protein identification methods depend on existing protein or nucleic acid databases for sequence matching. However, these methods are limited when confronted with new species, mutants, post-translational modifications, and truncated proteins. De Novo Sequencing Proteomics......

• • Detecting Protein-Protein Interactions

  Detecting Protein-Protein Interactions is a crucial technique for studying biomolecular collaboration within cells. Proteins typically do not function in isolation; instead, they form interaction networks that drive various biological processes, including signal transduction, metabolic regulation, and gene expression. Understanding these interactions provides deeper insights into disease mechanisms, facilitates the development of novel therapeutics, and enables innovative approaches in biotechnology. ......

• • Cross-Linking Protein-Protein Interaction

  Cross-Linking Protein-Protein Interaction analysis is a technique used to investigate complex protein networks within cells. Proteins, as key players in biological processes, interact to form intricate networks that regulate processes such as signal transduction, metabolic regulation, and cell cycle control. Understanding the specifics of these interactions helps to elucidate the functions and mechanisms of biological systems, and Cross-Linking Protein-Protein Interaction analysis serves as a powerful......

• • N-Terminal Amino Acid Determination

  N-terminal amino acid determination is a crucial technique in protein chemistry and proteomics. This method focuses on identifying the initial amino acid at the N-terminus of a protein or polypeptide chain, playing a significant role in foundational research and application development. By determining the N-terminal amino acid, researchers can set the stage for complete protein sequencing and gain insights into post-translational modifications, variations, and processing mechanisms. In the biotechnolo......

• • Advances in C-Terminal Sequencing Technology

  C-terminal sequencing is a technique used to analyze the amino acid sequence at the terminal end of a protein molecule. The C-terminal sequence plays a critical role in biological functions such as protein-protein interactions, intracellular localization signal recognition, and the regulation of enzyme activity. Understanding a protein's C-terminal sequence can aid scientists in elucidating its cellular functions and has significant implications in drug development, disease diagnosis, and other fields......

• • Mascot Peptide Mass Fingerprint

  Mascot Peptide Mass Fingerprint is a bioinformatics tool utilized for protein identification, particularly valuable in proteomics research. The core principle involves acquiring peptide mass data from protein samples through mass spectrometry, then matching this data to theoretical peptide masses in established protein databases for protein identification. Mascot, a widely adopted search engine, processes extensive mass spectrometry data, calculating match scores using specific algorithms to provide a......

• • Monoclonal Antibody Characterization Techniques

  Monoclonal antibody characterization techniques are essential for the detailed analysis and description of the properties of monoclonal antibodies. These antibodies, produced from a single B cell clone, exhibit high specificity and consistency, making them invaluable in diagnostics, therapeutics, and scientific research. The primary goal of characterization techniques is to thoroughly assess and control the structural, functional, and stability attributes of antibodies using diverse analytical methods......

• • Drug Target Identification

  Drug target identification is the process of using various techniques to identify and confirm specific biomolecules in organisms that interact with drugs to regulate disease-related biological processes. With the increasing complexity of diseases, traditional drug development methods face significant challenges. This approach offers a more precise strategy to target specific disease mechanisms while minimizing effects on other physiological functions.   Drug target identification has applications acro......

• • Characterization of Protease

  Characterization of protease involves a detailed analysis of their structure, function, and roles within biological systems. As enzymes that catalyze the hydrolysis of proteins, proteases are ubiquitous in living organisms and are integral to processes such as digestion, cell proliferation, signal transduction, and immune response. Altered expression or activity of proteases is often linked to diseases like cancer, neurodegenerative disorders, and cardiovascular conditions. Thus, characterization of p......