Resources
Proteomics Databases
Metabolomics Databases
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Proteomics and cancer research is an interdisciplinary field that integrates biochemistry, molecular biology, and bioinformatics to gain a deeper understanding of cancer initiation and progression through the study of protein structure, function, and interactions. Proteomics, the large-scale study of the complete set of proteins expressed in a biological system, offers a comprehensive view of both physiological and pathological cellular states. It is intimately linked to cancer research because protei......
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• Single-Cell Transcriptomics Analysis
Single-cell transcriptomics analysis is designed to elucidate the complexity and heterogeneity of gene expression at the level of individual cells. By precisely quantifying mRNA abundance in each cell, this technique enables the construction of detailed transcriptional landscapes across diverse physiological and pathological states. In contrast to conventional bulk transcriptomic analyses, single-cell transcriptomics analysis captures cell-specific expression patterns, allowing for deeper insights int......
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• X-Ray Crystal Structure Analysis
X-ray crystal structure analysis is a fundamental technique for elucidating the three-dimensional architecture of molecules. The method is based on interpreting the diffraction patterns generated by the interaction of X-rays with atoms in a crystalline lattice to determine the spatial arrangement of atoms within the crystal. This approach provides not only precise molecular geometries but also detailed information on electron density distributions, thereby enabling a deeper understanding of molecular ......
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• Metabolomics Pathway Analysis
Metabolomics pathway analysis is a powerful systems biology approach used to investigate alterations in metabolic profiles and the interactions among metabolites within biological systems. As a central component of systems-level research, metabolomics enables comprehensive profiling of small-molecule metabolites, offering insights into their concentrations, fluctuations, and dynamic regulatory mechanisms under physiological and pathological conditions. The implementation of metabolomics pathway analys......
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• Bioinformatics and Proteomics
Bioinformatics and proteomics represent two pivotal domains in contemporary biological research, each playing a fundamental role in elucidating the structure, function, and interactions of biomolecules. Bioinformatics applies computational algorithms and data-driven methodologies to analyze a wide array of biological datasets, ranging from genome sequence analysis to molecular dynamics simulation. Proteomics, on the other hand, focuses on the large-scale characterization of protein expression, post-tr......
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• Proteome Discoverer Label-Free Quantification
Proteome discoverer label-free quantification is one of the most widely employed and efficient strategies in contemporary proteomics research. This approach enables relative quantification of proteins or peptides across different biological samples by measuring signal intensities through mass spectrometry, without the incorporation of stable isotopes or chemical labeling reagents. As an intensity-based mass spectrometric quantification method, proteome discoverer label-free quantification offers advan......
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• Identification and Proteomic Profiling of Exosomes in Human Urine
The identification and proteomic profiling of exosomes in human urine has emerged as a rapidly advancing and highly promising technique in biomedical research. Exosomes are nanoscale (30–150 nm) membrane-bound vesicles secreted by cells and are abundantly present in various bodily fluids, including blood, saliva, and urine. They serve as carriers of proteins, lipids, and RNAs, and play pivotal roles in intercellular communication and the regulation of physiological processes. Compared to other bioflui......
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Kinase enrichment analysis is a specialized proteomics technique for investigating protein kinases and their substrate activities. It is widely applied in cell signaling research, cancer studies, drug discovery, and the elucidation of disease mechanisms. Protein kinases serve as key regulators in cellular processes, mediating phosphorylation to control critical biological functions such as cell proliferation, differentiation, apoptosis, and metabolism. Given the strong association between aberrant kin......
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• In Silico Analysis of Protein
In silico analysis of protein refers to a computational approach for the systematic processing and biological interpretation of proteomic data. This methodology spans multiple layers, from the identification and quantification of raw mass spectrometry outputs to protein function annotation, structural prediction, and signaling pathway mapping. As a critical technological pillar in the advancement of proteomics, it is fundamentally driven by high-performance computing and algorithmic modeling to enable......
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DepMap Proteomics is a rapidly developing research field that integrates large-scale genomics and proteomics data to identify genes and proteins essential for cancer cell survival. Cancer cells heavily rely on specific genes and proteins for survival and proliferation, making these dependencies promising therapeutic targets. DepMap studies utilize CRISPR or RNAi-based gene knockout technologies to systematically identify key dependency genes across various cancer types. By integrating proteomics data,......
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