Resources
Proteomics Databases
Metabolomics Databases
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• Mass Spectrometry-Based Chemical Proteomics
Mass spectrometry-based chemical proteomics merges chemical probes, mass spectrometry, and bioinformatics to elucidate the functions, structures, and interactions of proteins within cellular environments. This sophisticated technique offers efficient and precise identification of proteins along with their post-translational modifications. Its applications extend to uncovering protein mechanisms, identifying drug targets, and deciphering signal transduction pathways in intricate biological systems. Suc......
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• Mass Spectrometry-Based Label-Free Quantitative Proteomics
Mass spectrometry-based label-free quantitative proteomics serves as an analytical technique for assessing the absolute and relative abundance of proteins within biological samples. Unlike traditional isotopic or chemical labeling methods, this label-free approach directly quantifies proteins by measuring the signal intensities from mass spectrometry. The foremost advantage of this methodology lies in its ability to bypass complex sample preparation, enabling more rapid and cost-effective handling of ......
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Phosphoprotein analysis, a specialized area within proteomics, focuses on the locations, regulatory mechanisms, and biological functions of phosphorylation within proteins. Phosphorylation, one of the most prevalent post-translational modifications, is controlled by protein kinases and phosphatases. It regulates protein activity, structure, and interactions dynamically by adding or removing phosphate groups at specific amino acid residues, including serine, threonine, and tyrosine. This modification i......
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• Mass Spectrometry of Amino Acids
Mass spectrometry of amino acids is a scientific technique employed for the qualitative and quantitative analysis of amino acids and their derivatives utilizing mass spectrometry. Amino acids, as fundamental constituents of proteins, play pivotal roles in organisms, including the construction of cellular tissues, involvement in metabolic reactions, and facilitation of signal transduction and immune responses. Due to its high sensitivity, specificity, and throughput, mass spectrometry of amino acids se......
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Protein amino acid analysis is a crucial technique for examining the composition and structure of proteins by determining the types and quantities of amino acids they contain. This analysis offers essential data for understanding protein functions, refining production processes, and developing novel bioproducts. Amino acids, as the fundamental building blocks of proteins, have specific types, proportions, and sequences that dictate protein functionality. This analysis is vital across multiple fields. ......
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PMF proteomics is a protein identification method that utilizes mass spectrometry to analyze the molecular weights of peptide fragments generated by enzymatic digestion of proteins. This process results in a unique "fingerprint" pattern that can be compared against a database for protein identification. PMF proteomics finds applications across various fields. In medical research, PMF is extensively used to identify disease-related proteins, thereby uncovering the molecular mechanisms of diseases. For ......
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• Protein Aggregation Analysis
Protein aggregation analysis is a technique used to study the formation of protein aggregates under specific conditions and their impact on biological functions and the stability of systems. Protein aggregation involves the formation of either insoluble or soluble aggregates through intermolecular interactions due to factors like denaturation, misfolding, or environmental stress. This phenomenon can serve as a normal regulatory process in biological systems or contribute to the pathology of various di......
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Phosphorylation analysis is an experimental technique integral to proteomics and metabolomics research, focusing on identifying phosphorylation sites, monitoring their dynamic changes, and elucidating their role in biological processes. As a key post-translational modification, phosphorylation is regulated by kinases and phosphatases, which reversibly attach phosphate groups to substrates, thereby modulating their function, activity, and stability. This analysis is pivotal in signal transduction, cell......
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• Plant-Based Protein Amino Acid Profile
The plant-based protein amino acid profile analysis is a crucial approach for investigating the structural and functional characteristics of plant proteins. By quantifying and comparing the types, concentrations, and proportions of amino acids in proteins, this method provides essential insights into the biological traits of plants, crop quality improvement, and the development of plant protein resources. As a natural amino acid source, plant proteins play a critical role in human nutrition, animal fe......
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Mascot protein analysis is a widely utilized bioinformatics tool in proteomics for interpreting mass spectrometry data and identifying proteins. This tool functions by comparing experimental mass spectrometry spectra with predicted spectra from known protein databases to identify proteins present in samples. Typically, mass spectrometry data are derived from peptide fragments. Through this approach, researchers can dissect the protein composition of complex biological samples. Mascot's primary role is......
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