Resources
Proteomics Databases
Metabolomics Databases
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• Identification and Proteomic Profiling of Exosomes in Human Urine
The identification and proteomic profiling of exosomes in human urine has emerged as a rapidly advancing and highly promising technique in biomedical research. Exosomes are nanoscale (30–150 nm) membrane-bound vesicles secreted by cells and are abundantly present in various bodily fluids, including blood, saliva, and urine. They serve as carriers of proteins, lipids, and RNAs, and play pivotal roles in intercellular communication and the regulation of physiological processes. Compared to other bioflui......
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Kinase enrichment analysis is a specialized proteomics technique for investigating protein kinases and their substrate activities. It is widely applied in cell signaling research, cancer studies, drug discovery, and the elucidation of disease mechanisms. Protein kinases serve as key regulators in cellular processes, mediating phosphorylation to control critical biological functions such as cell proliferation, differentiation, apoptosis, and metabolism. Given the strong association between aberrant kin......
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• In Silico Analysis of Protein
In silico analysis of protein refers to a computational approach for the systematic processing and biological interpretation of proteomic data. This methodology spans multiple layers, from the identification and quantification of raw mass spectrometry outputs to protein function annotation, structural prediction, and signaling pathway mapping. As a critical technological pillar in the advancement of proteomics, it is fundamentally driven by high-performance computing and algorithmic modeling to enable......
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DepMap Proteomics is a rapidly developing research field that integrates large-scale genomics and proteomics data to identify genes and proteins essential for cancer cell survival. Cancer cells heavily rely on specific genes and proteins for survival and proliferation, making these dependencies promising therapeutic targets. DepMap studies utilize CRISPR or RNAi-based gene knockout technologies to systematically identify key dependency genes across various cancer types. By integrating proteomics data,......
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PROTAC Synthesis represents a rapidly advancing area in medicinal chemistry, centered on the development of a novel class of small-molecule agents—PROTACs. Unlike conventional inhibitors that act solely on the active sites of proteins, PROTACs harness the cell’s ubiquitin–proteasome system to induce the selective degradation of pathogenic proteins, thereby eliminating them at the functional level. PROTAC Synthesis involves the conjugation of two functional ligands—one that binds to the target protein and...
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• Single Cell miRNA Sequencing
Single cell miRNA sequencing is an advanced methodology designed to profile microRNA (miRNA) expression at the resolution of individual cells. This technique integrates single-cell isolation, high-throughput sequencing, and small RNA analysis to enable the precise delineation of heterogeneous miRNA expression patterns among distinct cell populations. miRNAs are ~22-nucleotide non-coding RNAs that are ubiquitously present in eukaryotic organisms, playing essential roles in gene regulation, cell fate ........
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Single cell BCR sequencing is a high-throughput technology that enables the analysis of B cell receptor (BCR) sequences and expression profiles at single-cell resolution. BCRs are membrane-bound immunoglobulins expressed on the surface of B cells that specifically recognize foreign antigens, initiating the humoral immune response. Upon antigen exposure, B cells are activated through BCR recognition and subsequently undergo clonal expansion, somatic hypermutation, and class switching to produce.........
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Small molecule discovery is a critical methodology in biomedical research, aiming to identify, optimize, and validate biologically active compounds from the vast and complex chemical space. These compounds are typically low-molecular-weight organic molecules capable of modulating protein activity, signaling pathways, or cellular functions, thereby contributing to advancements in drug development, chemical biology, and precision medicine. The primary objective of small molecule discovery is to identify......
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• Single Cell and Spatial Transcriptomics
Single cell and spatial transcriptomics represent groundbreaking technologies that enable the resolution of gene expression at the single-cell level while simultaneously preserving the spatial localization of cells within tissue contexts. Conventional transcriptomic analyses, which rely on bulk cell populations, often mask cellular heterogeneity and thus limit the resolution at which complex biological systems can be understood. The emergence of single cell and spatial transcriptomics offers a ........
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PROTAC degradation represents an innovative approach to precise protein regulation, leveraging the endogenous ubiquitin–proteasome system to selectively degrade target proteins and thereby inhibit their function. Unlike traditional small-molecule inhibitors that merely suppress protein activity, PROTAC degradation removes the target protein entirely from the intracellular environment. A PROTAC (Proteolysis Targeting Chimera) is a bifunctional molecule composed of two ligands—one specific for the target.....
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