Resources

Proteomics Databases



Metabolomics Databases

• • Proximity Extension Assay PEA Technology

  Proximity extension assay PEA technology is a highly sensitive and specific molecular analysis method used to detect and quantify target proteins in proteomics. This technique utilizes a pair of specific antibodies that bind to the target protein, followed by DNA sequence ligation and amplification, enabling ultra-high sensitivity and specificity in protein detection. The core principle of proximity extension assay PEA technology relies on a phenomenon called the "proximity effect," whereby the DNA s......

• • Solid Phase Peptide Synthesis

  Solid phase peptide synthesis (SPPS) is a widely used chemical method for the stepwise synthesis of peptides on an insoluble solid support. First introduced by Robert Bruce Merrifield in 1963, solid phase peptide synthesis (SPPS) has become a fundamental technique in biochemistry and biotechnology. The process involves sequentially adding amino acids to a solid phase resin, greatly enhancing both the efficiency and purity of peptide synthesis. SPPS has broad applications, including drug development, ......

• • Quantitative Proteomics in Disease and Drug Discovery

  Quantitative proteomics is an advanced technique designed to accurately measure and compare protein expression levels across different samples. Unlike traditional proteomics methods, quantitative proteomics not only identifies proteins but also provides detailed information on their relative or absolute abundances under various biological conditions. One of the primary advantages of this technique is its ability to capture dynamic changes in protein levels, which often reflect the physiological or pat......

• • Protein Analysis Enhancing Scientific Discovery

  Protein analysis plays a pivotal role in elucidating the molecular mechanisms underlying biological processes. By thoroughly examining proteins, researchers gain insights into their structure, function, interactions, and variations across biological contexts. This knowledge is crucial for advancing fundamental research, improving disease diagnostics, and developing novel therapeutics. A major challenge in protein research lies in the efficient separation and extraction of samples. Given the diversity ......

• • Top Down Proteomics for Protein Analysis

  Top down proteomics is an advanced technology that has been gaining increasing prominence in the field of protein research. Compared to traditional proteomics methods, this approach analyzes intact proteins directly, avoiding the conventional enzymatic digestion step, and thus provides more detailed and comprehensive protein information. It offers distinct advantages, particularly in the study of protein post-translational modifications, protein variants, and structural complexities. This technology i......

• • MALDI-TOF Mass Spectrometry in Proteomics

  MALDI-TOF Mass Spectrometry integrates Matrix-Assisted Laser Desorption/Ionization (MALDI) with Time-of-Flight Mass Spectrometry (TOF-MS). Since its introduction by Karas and Hillenkamp in 1988, this technique has become a cornerstone of modern mass spectrometry due to its high resolution, broad mass range, and rapid analytical capabilities. It has been extensively utilized in proteomics, metabolomics, clinical diagnostics, environmental monitoring, and forensic investigations.   The MALDI-TOF Mass Sp......

• • Protein Mass Spectrometry for Drug Development

  Protein mass spectrometry is a powerful analytical technique widely used in life sciences, including proteomics research, disease mechanism investigation, and drug development. By precisely measuring the mass and structural characteristics of proteins and their modifications, it provides researchers with essential tools for gaining in-depth insights into biological systems. As a high-sensitivity and high-resolution technique, mass spectrometry is capable of analyzing complex biological samples, reveal......

• • Intact Protein Mass Spectrometry Service in Proteomics Studies

  Intact protein mass spectrometry service is designed to analyze the molecular weight and structural features of non-degraded, full-length proteins. This method plays a crucial role in protein science, particularly in elucidating protein modification states, structural conformations, and molecular interactions. By leveraging this technique, researchers can acquire detailed insights into proteins in their native conformations, providing critical data for advancing the understanding of protein functions.......

• • Edman Degradation for Protein Sequence Analysis

  Edman degradation is a classical protein sequencing technique that facilitates the sequential identification of amino acids from the N-terminus of a polypeptide chain. Developed in the 1950s by Swedish chemist Pehr Edman, this method was instrumental in the early stages of molecular biology, establishing a cornerstone for the study of protein structure and function.   Edman degradation relies on the selective chemical reaction of the N-terminus of a polypeptide with phenyl isothiocyanate (PITC), formi......

• • Accurate Mass Determination in Analytical Applications

  Accurate Mass Determination refers to the measurement of compound molecular mass using high-resolution mass spectrometry, characterized by exceptional precision and reliability. This technique finds extensive applications in fields such as analytical chemistry, pharmaceutical research, environmental science, and the study of macromolecules. By enabling the precise measurement of molecular mass, it facilitates detailed compound identification and structural elucidation.   At its core, Accurate Mass Det......