Resources

Proteomics Databases



Metabolomics Databases

• • Methionine Oxidation Mass Spectrometry

  Methionine oxidation mass spectrometry is a specialized technique used to detect and analyze the oxidation of methionine residues in proteins. Methionine, a sulfur-containing amino acid found abundantly in proteins, is prone to oxidation, which allows it to play a crucial regulatory role in biological systems. The oxidation of methionine can alter protein function, influencing cell signaling, protein folding, and enzyme activity. By assessing the oxidation state of methionine in protein samples, this ......

• • Glycan Analysis of Therapeutic Glycoproteins

  Glycan analysis of therapeutic glycoproteins is pivotal in modern biomedical research. Glycoproteins, composed of proteins and carbohydrate chains, play essential roles in cell recognition, signal transduction, and immune responses. In therapeutic contexts, many drugs, including monoclonal antibodies and fusion proteins, are glycoproteins. The analysis of glycans aids in evaluating and mitigating the immunogenicity risks associated with therapeutic glycoproteins. Glycan analysis involves the detailed ......

• • Qualitative Analysis of Amino Acid

  Qualitative analysis of amino acid involves identifying different types of amino acids within biological samples through advanced separation and detection methods. These analyses help elucidate the compositional characteristics and biological functions of amino acids, which are the fundamental units of proteins involved in constructing cellular structures, regulating metabolic pathways, and facilitating neural conduction and signal transmission. Variations in amino acid types and their relative concen......

• • Bottom-Up and Top-Down Proteomics

  Bottom-up and top-down proteomics represent two key methodologies in proteomics research, aimed at decoding protein structure, function, and interactions. In bottom-up proteomics, proteins are enzymatically digested into smaller peptides. These peptides are then analyzed using sensitive techniques like mass spectrometry to identify and quantify them. The essence of this method lies in deducing the properties and functions of entire proteins from peptide data. Consequently, bottom-up proteomics is exte......

• • High-Throughput Protein Sequencing

  High-throughput protein sequencing is a method that utilizes advanced mass spectrometry to rapidly analyze and identify large numbers of proteins. This technique surpasses traditional protein sequencing methods by enabling the analysis of larger sample sizes within shorter time frames, thereby achieving significant advancements in both "quality" and "quantity." The essence of this technology involves the precise mass measurement of peptides by mass spectrometers, coupled with bioinformatics algorithms......

• • Mass Spectrometry Phosphorylation Site Analysis

  Mass spectrometry phosphorylation site analysis is a powerful technique based on mass spectrometry for identifying and examining phosphorylation sites in proteins. As the most prevalent post-translational modification (PTM), phosphorylation regulates protein activity, stability, and molecular interactions. This modification allows cells to swiftly respond to external stimuli and modulate signaling pathways. Through precise identification of phosphorylation sites, this technique provides critical insig......

• • Glycomics and Glycoproteomics

  Glycomics and glycoproteomics are scientific disciplines focused on the study of carbohydrates within biological systems and their functional roles in cellular processes. Glycomics investigates the structures and functions of carbohydrates, emphasizing their involvement in cell communication and signal transduction pathways. In contrast, glycoproteomics delves into the glycosylation modifications on proteins, analyzing the specific sites and types of modifications and their regulatory effects on prote......

• • Amino Acid LC-MS

  Amino acid LC-MS analysis is a powerful analytical technique that integrates liquid chromatography (LC) and mass spectrometry (MS) to detect and quantify amino acids in complex biological matrices. As fundamental constituents of proteins, amino acids play crucial roles in diverse biological processes such as cellular growth, repair, signaling, and metabolic regulation. Thus, precise measurement of amino acid composition and concentration provides significant insights into biochemical processes, diseas......

• • Amino Acid HPLC Analysis

  Amino acid HPLC analysis is a critical technique for detecting and analyzing amino acid composition and content in samples. This method, widely employed in analytical chemistry, achieves compound separation through the passage of a liquid mobile phase over a solid stationary phase. Amino acids, as the fundamental building blocks of proteins in organisms, are crucial in various fields such as biomedicine, nutrition, food science, and drug development. With its high resolution, sensitivity, and reproduc......

• • Protein Extraction and Quantification

  Protein extraction and quantification are essential procedures in biological science research, with widespread applications in fields such as biomedicine, drug discovery, and agricultural science. Proteins are fundamental to life, playing key roles in cell structure, metabolic regulation, and signal transduction. To gain insights into these functions, scientists extract and quantify proteins from cells or tissues. The primary goal of protein extraction is to isolate proteins from other cellular compon......