Resources
Proteomics Databases
Metabolomics Databases
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• Determination of Crude Protein Content
The determination of crude protein content involves quantitatively analyzing the total protein content in a sample using scientific analytical methods. This process is widely applied in fields such as food science, agriculture, animal husbandry, and biotechnology. Crude protein refers to the total protein in a sample and serves as the primary source of nitrogen in both plant and animal tissues, typically estimated through nitrogen content measurement. In the food industry, determining the crude protei......
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• Olink Proteomics in Drug Development and Disease Research
Olink proteomics leverages innovative technologies developed by Olink to enable precise and high-throughput protein analysis. Central to this platform is the Proximity Extension Assay (PEA) technology, which uses paired antibody-conjugated DNA probes. Upon binding to target proteins, these probes initiate a chain reaction amplification, allowing for the sensitive and specific detection of up to thousands of proteins. This approach has become indispensable in biomedical research, facilitating biomarker......
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Proximity Extension Assay (PEA) is a novel protein detection technique that offers high sensitivity and specificity. The principle behind PEA relies on the binding of two antibodies to the same target protein, with DNA sequences attached to these antibodies becoming sufficiently close to each other. This proximity enables the formation of a detectable double-stranded DNA signal through an extension reaction. By combining the specificity of antibodies with the amplification power of nucleic acids, PEA ......
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Biomarker discovery involves identifying and validating substances or molecules within organisms using a variety of technical approaches. These molecules can serve as indicators of normal biological or pathological processes or as markers for therapeutic responses. Biomarkers may include DNA, RNA, proteins, metabolites, or even cell populations. Among these, proteomics-based mass spectrometry has emerged as an essential tool in biomarker discovery. In the medical field, biomarkers have transformed the......
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Custom peptides are synthesized peptide sequences tailored to specific research objectives or application requirements. These peptides can be precisely designed in terms of length, amino acid sequence, and chemical modifications to address specific scientific or industrial challenges. In medical research, custom peptides have broad applications, including vaccine development, antibody production, and drug target validation. Through rational design and synthesis, they can emulate the functional propert......
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Target identification refers to the process of determining the interaction between a drug or molecule and a specific biological target, such as a protein or nucleic acid, within an organism. As a central element in biological mechanisms, target identification is pivotal in uncovering the action mechanisms of drugs in cells, tissues, or organs, thereby facilitating the development of novel therapeutics, precision medicine strategies, and a deeper understanding of disease pathogenesis. This methodology ......
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• Advancements in Peptide Synthesis Methods Applications and Innovations
Peptide synthesis refers to the chemical or biological assembly of amino acids in a defined sequence to form peptide chains. Peptides, typically composed of 50 or fewer amino acid residues linked by peptide bonds, are ubiquitous in living organisms and serve critical biological functions. Key roles include acting as hormones, neurotransmitters, immune regulators, and antimicrobial agents. Their small size enables peptides to play indispensable roles in cellular signaling, immune modulation, and growth......
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• Selected Reaction Monitoring
Selected Reaction Monitoring (SRM) is a mass spectrometry-based quantitative technique extensively utilized in proteomics research. By targeting specific precursor ions and their corresponding product ions, SRM achieves exceptional sensitivity and specificity in detecting analytes. Initially developed for small molecule analysis, its application has expanded significantly due to its robustness in quantifying components within complex biological samples. In proteomics, Selected Reaction Monitoring is a......
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Single molecule sequencing (SMS) is an innovative technology that focuses on analyzing individual molecules, offering a distinct advantage over traditional population-based sequencing methods. By enabling real-time monitoring of single molecules, SMS eliminates the need for PCR amplification or DNA/RNA fragmentation, thus avoiding biases and errors associated with amplification processes. This precision makes it particularly suitable for studying complex genomes, rare mutations, and epigenetic modific......
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• De Novo Peptide Sequencing in Proteomics Applications
De novo peptide sequencing is a technique used to directly infer the amino acid sequence of unidentified peptide fragments from mass spectrometry data. Unlike traditional database search methods, it does not rely on pre-existing protein sequence databases. Instead, it derives peptide sequences by analyzing the fragmentation patterns of ions present in the mass spectrometry data. This technology plays a pivotal role in proteomics research, particularly for investigating newly discovered proteins, speci......
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