Resources
Proteomics Databases
Metabolomics Databases
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• Amino Acid Mass Spectrometry
Amino acid mass spectrometry refers to analytical methods utilizing mass spectrometry to achieve highly sensitive and specific qualitative and quantitative analysis of amino acids and their derivatives. As the fundamental building blocks of proteins, amino acids play critical roles in various biological processes, including metabolism, signal transduction, and the pathogenesis of diseases. Amino acid mass spectrometry enables accurate profiling of amino acid composition and concentration changes in trace...
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LCMS proteomics represents a cutting-edge analytical platform for characterizing protein composition and abundance within complex biological matrices. This approach has broad utility in biomedical research, offering insights into disease mechanisms and enabling the discovery of candidate biomarkers that facilitate the development of personalized medicine. For instance, by profiling proteomic alterations in cancer patients, researchers can identify proteins associated with disease progression, thereby.......
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• Biomarker-Based Drug Development
Biomarker-based drug development is a systematic approach that drives the discovery, validation, and clinical application of novel therapeutics through the identification and utilization of specific biomarkers. Biomarkers are typically defined as molecules or characteristics that objectively indicate physiological or pathological states within the body—such as proteins, nucleic acids, and metabolites—which are commonly found in biological samples including blood, urine, and tissue. The primary objective....
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Tandem Liquid Chromatography–Mass Spectrometry (LC-MS/MS) is a powerful analytical technique that integrates the separation efficiency of liquid chromatography (LC) with the sensitivity and specificity of tandem mass spectrometry (MS/MS). This method has been widely applied across diverse fields, including life sciences, pharmaceutical development, clinical diagnostics, environmental monitoring, and food safety. The core strength of Tandem LC-MS lies in its ability to first separate compounds in complex....
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• Single Crystal X-ray Structure Analysis
Single crystal X-ray structure analysis is a powerful technique for elucidating the atomic and molecular structures of substances. By analyzing the diffraction patterns of single crystal samples, researchers can precisely determine the spatial arrangement of atoms within the sample. This method not only reveals both intra- and intermolecular interactions but also provides detailed information on bond lengths and angles, laying a solid foundation for a deeper understanding of the chemical and physical ......
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Organelle proteomics refers to a research approach that systematically identifies, quantifies, and functionally annotates all proteins localized within specific organelles. Organelles, such as mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, and the nucleus, are subcellular structures responsible for executing diverse biological functions. The proteins constituting these organelles not only play essential roles in maintaining their individual functions but also participate in coordinated....
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• Biolayer Interferometry Data Analysis
Biolayer interferometry data analysis is a high-precision technique that utilizes the principles of optical interference to monitor biomolecular interactions in real time. By detecting the rate and extent of molecule binding or dissociation on a solid surface, it provides quantitative information on kinetic parameters such as the association rate constant (kon), dissociation rate constant (koff), and affinity constant (KD). Biolayer interferometry is an indispensable analytical tool in biochemical and......
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• Single Cell Whole Exome Sequencing
Single cell whole exome sequencing is a genomic technology focused on sequencing the exome at the resolution of individual cells. Exons represent the protein-coding regions of the genome, and even subtle variations in their sequences can profoundly alter protein structure and function, ultimately influencing vital biological processes. By leveraging single cell whole exome sequencing, researchers can investigate cellular heterogeneity in diseases such as cancer with unprecedented detail. This is parti......
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• Plasma Amino Acid Analysis for Diagnosis
Plasma amino acid analysis for diagnosis is a laboratory method used to identify potential metabolic disorders or underlying diseases by precisely measuring the concentration and ratio of various amino acids in plasma. Amino acids, as fundamental components of proteins, also independently engage in numerous physiological processes such as energy metabolism, neural signaling, hormone synthesis, and immune regulation. Variations in their levels can indicate the health status of an organism. Given their ......
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• MALDI-TOF for protein identification
MALDI TOF for protein identification is a technique that combines matrix-assisted laser desorption/ionization (MALDI) with time-of-flight mass spectrometry (TOF). In proteomics research, understanding and identifying the structure and function of proteins is essential. MALDI TOF for protein identification determines the composition and structural information of proteins by analyzing their mass-to-charge ratio (m/z), with the key advantage of enabling accurate mass measurement without compromising prot......
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