Resources

• • Principle of Immunopeptidomics

  Immunopeptidomics is a field of study that employs mass spectrometry (MS) to investigate peptides related to the immune system. The focus is on detecting and analyzing antigenic peptides presented by the major histocompatibility complex (MHC). These antigenic peptides, typically 8-15 amino acids long, are fragments of intracellular proteins that are processed and presented on the cell surface by MHC molecules. They are then recognized by T-cell receptors (TCRs), triggering an immune response.

• • Application of Mass Spectrometry in Peptidomics

  Peptidomics is a branch of proteomics that focuses on studying peptides' composition, structure, function, and dynamic changes in biological samples. It plays a significant role in protein identification, biomarker discovery, and drug development. Mass spectrometry (MS), a highly sensitive and accurate analytical technique, has become widely used in peptidomics.

• • Workflow of Peptidomics for Endogenous Peptide Analysis

  Peptidomics is a critical sub-discipline that investigates the composition, structure, function, and dynamics of peptides in biological samples. Endogenous peptides, short-chain molecules generated by the degradation of proteins or non-translational pathways, play pivotal roles in various physiological processes, including signal transduction, immune regulation, and metabolic control.

• • Advantages and Limitations of Peptidomics in Biological Sample Analysis

  Peptidomics, a large-scale analysis technique focused on peptide molecules, has gained widespread application in biomedical research in recent years. As a vital branch of proteomics, peptidomics provides in-depth insights into specific physiological or pathological states by directly studying peptide molecules in biological samples. Scientists mainly analyze naturally occurring small peptides within biological specimens, such as blood, urine, and cerebrospinal fluid.

• • Aseptic Testing of Recombinant Protein Vaccines

  Recombinant protein vaccines are a type of vaccine that does not contain complete pathogens, but is formulated with specific protein antigens produced in heterologous expression systems. Recombinant protein vaccines have become increasingly popular among researchers in recent years due to their advantages such as good safety, strong stability, and low cost.

• • Measurement of Optical Rotation in Antibody Drugs

  Antibody drugs are a class of drugs that are synthesized artificially to treat diseases by specifically binding to target molecules. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, and antibody-drug conjugates. Antibody drugs have shown significant efficacy in treating various diseases such as cancer, autoimmune diseases, inflammatory diseases, immunomodulation, and ophthalmic diseases.

• • AUC Analysis of Recombinant Protein Drugs

  Recombinant protein drugs refer to protein products derived from animals and plants through biotechnological research and development, which possess certain biological activities and can prevent and diagnose diseases in humans, animals, and plants. Compared to small molecule drugs, recombinant protein drugs have advantages such as high activity, high specificity, and low toxicity, making them favored by many researchers.

• • Mechanism of Peptide Biomarker-Based Diagnostics

  Peptide biomarkers have recently demonstrated significant potential in early disease diagnosis, monitoring disease progression, and evaluating prognosis. Due to their involvement in various pathological processes, peptide biomarkers are extensively used in detecting diseases such as cancer, cardiovascular conditions, and neurodegenerative disorders.

• • Application of Peptide Biomarker Discovery in Disease Diagnostics

  With the advancement of biotechnology and medicine, early disease diagnosis and precision medicine have become increasingly significant. The discovery and application of biomarkers have greatly advanced clinical detection methods. Peptides, as an important class of biomolecules, have gradually become a valuable tool in disease diagnosis due to their stability, specificity, and ease of detection.

• • Mechanism of Mass Spectrometry-Based Peptide Identification

  Mass spectrometry (MS), a highly sensitive and specific analytical tool, has found widespread applications in proteomics research. Particularly, MS-based peptide identification technology enables the efficient and accurate detection of peptides in biological samples, providing critical data for protein quantification and functional studies.